KEGG   DRUG: ProligestoneHelp
Entry
D08429                      Drug                                   

Name
Proligestone (INN);
Covinan [veterinary] (TN);
Delvosteron [veterinary] (TN)
Formula
C24H34O4
Exact mass
386.2457
Mol weight
386.5244
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01666  Progesterone receptor agonist
 DG02004  Progesterone
Efficacy
Estrus suppressant (veterinary)
Comment
Progestin
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D08429  Proligestone (INN)
    NR3C3 (PGR)
     D08429  Proligestone (INN)
Animal drugs in Japan [BR:br08331]
 94  Agents for breeding
  941  Hormone preparations (except posterior-pituitary hormone and preparations)
   9415  Luteinizing hormone and preparations
    D08429  Proligestone (INN)
BRITE hierarchy
Other DBs
CAS: 23873-85-0
PubChem: 96025115
ChEMBL: CHEMBL2106696
LigandBox: D08429
NIKKAJI: J15.818F
LinkDB All DBs
KCF data Show

ATOM        28
            1   C1x C    19.3900  -27.4400
            2   C5x C    19.3900  -28.8400
            3   C2x C    20.6024  -29.5400
            4   C2y C    21.8149  -28.8400
            5   C1z C    21.8149  -27.4400
            6   C1x C    20.6024  -26.7400
            7   C1x C    23.0273  -29.5400
            8   C1x C    24.2397  -28.8400
            9   C1y C    24.2397  -27.4400
            10  C1y C    23.0273  -26.7400
            11  C1z C    25.4522  -26.7400
            12  C1z C    25.4522  -25.3400
            13  C1x C    24.2397  -24.6400
            14  C1x C    23.0273  -25.3400
            15  O2x O    26.6646  -27.4400
            16  C1y C    27.8770  -26.7400
            17  O2x O    27.8770  -25.3400
            18  C1z C    26.6646  -24.6400
            19  O5x O    18.1776  -29.5400
            20  C1a C    21.8149  -26.0402
            21  C1a C    25.4522  -23.9403
            22  C5a C    26.6646  -23.2400
            23  C1a C    27.8811  -22.5377
            24  O5a O    25.4562  -22.5423
            25  C1x C    26.7346  -26.6700
            26  C1x C    27.0846  -25.6900
            27  C1b C    29.0766  -27.4327
            28  C1a C    30.2659  -26.7460
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   12  18 1
            22    2  19 2
            23    5  20 1 #Up
            24   12  21 1 #Up
            25   18  22 1
            26   22  23 1
            27   22  24 2
            28   11  25 1 #Up
            29   18  26 1 #Up
            30   25  26 1
            31   16  27 1
            32   27  28 1

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