Entry |
|
Name |
Rifampicin sodium; Rifadine (TN) |
Formula |
C43H58N4O12. Na
|
Exact mass |
845.3949
|
Mol weight |
845.93
|
Structure |
|
Simcomp |
|
Class |
Antibacterial
DG01966 Antitubercular
DG01598 Rifamycin antibiotic
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG03195 UGT inducer
Transporter inhibitor
DG02865 SLCO1B1 inhibitor
DG02907 SLCO1B3 inhibitor
Transporter inducer
DG01893 ABCB1 inducer
|
Remark |
Product (DG00639): | D00211<JP/US> |
|
Efficacy |
Antibacterial (tuberculostatic), RNA polymerase inhibitor |
Comment |
Semisynthetic analog of Rifamycin [DR: D02549]
|
Target |
|
Pathway |
|
Interaction |
CYP induction: CYP3A4 [HSA: 1576]
Transporter induction: ABCB1 [HSA: 5243]
Enzyme induction: UGT [KO: K00699]
Transporter inhibition: SLCO1B1 [HSA: 10599], SLCO1B3 [HSA: 28234]
|
Structure map |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J04 ANTIMYCOBACTERIALS
J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
J04AB Antibiotics
J04AB02 Rifampicin
D08479 Rifampicin sodium
Drug groups [BR:br08330]
Antibacterial
DG01966 Antitubercular
DG01598 Rifamycin antibiotic
DG00639 Rifampicin
D08479 Rifampicin sodium
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00639 Rifampicin
D08479 Rifampicin sodium
DG03195 UGT inducer
DG00639 Rifampicin
D08479 Rifampicin sodium
Transporter inhibitor
DG02865 SLCO1B1 inhibitor
DG00639 Rifampicin
D08479 Rifampicin sodium
DG02907 SLCO1B3 inhibitor
DG00639 Rifampicin
D08479 Rifampicin sodium
Transporter inducer
DG01893 ABCB1 inducer
DG00639 Rifampicin
D08479 Rifampicin sodium
Antimicrobials [BR:br08307]
Antibacterials
Nucleic acid synthesis inhibitor
Rifamycin
D08479 Rifampicin sodium
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08479
Drug transporters
D08479
Drug groups [BR:br08330]
Antibacterial
DG01966 Antitubercular
DG01598 Rifamycin antibiotic
DG00639 Rifampicin
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00639 Rifampicin
DG03195 UGT inducer
DG00639 Rifampicin
Transporter inhibitor
DG02865 SLCO1B1 inhibitor
DG00639 Rifampicin
DG02907 SLCO1B3 inhibitor
DG00639 Rifampicin
Transporter inducer
DG01893 ABCB1 inducer
DG00639 Rifampicin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Nucleic acid synthesis inhibitor
Rifamycin
DG00639 Rifampicin
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Other DBs |
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LinkDB |
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KCF data |
ATOM 60
1 C1c C 20.5100 -14.4200
2 C1c C 20.5100 -15.8200
3 O1a O 22.8900 -15.7500
4 C1c C 22.8900 -14.4200
5 C1c C 21.6300 -13.7900
6 C2b C 25.2000 -14.4200
7 C1c C 24.0100 -13.7900
8 C5a C 26.3900 -16.5200
9 C2c C 27.5100 -15.8200
10 C2b C 27.5100 -14.4200
11 C2b C 26.3900 -13.7900
12 C1a C 24.0100 -12.3900
13 C1a C 21.6300 -12.3900
14 O1a O 19.3900 -13.7900
15 C1a C 28.7000 -16.5200
16 O5a O 25.2700 -15.8200
17 N1b N 26.3900 -18.1300
18 C1c C 19.3900 -16.5200
19 O7a O 18.2000 -15.8200
20 C1c C 19.3900 -18.1300
21 C8y C 25.2700 -18.8300
22 C8y C 25.2700 -20.1600
23 C8y C 24.0100 -18.1300
24 C8y C 22.8900 -18.8300
25 C8y C 22.8900 -20.1600
26 C8y C 24.0100 -20.8600
27 C8y C 21.7000 -18.1300
28 C8y C 20.5100 -18.8300
29 C8y C 20.5100 -20.1600
30 C8y C 21.7000 -20.8600
31 O1a O 24.0100 -16.8000
32 O1a O 21.7000 -16.8000
33 C1a C 19.3900 -14.7700
34 C7a C 17.0100 -15.1900
35 C1a C 15.8900 -15.8200
36 O6a O 17.0100 -13.7900
37 C1c C 18.2000 -18.8300
38 O2a O 17.0800 -18.1300
39 C2b C 18.2000 -20.1600
40 C1a C 18.2000 -17.2200
41 C1a C 15.8900 -18.8300
42 C2b C 17.0800 -20.8600
43 O2a O 17.0800 -22.1900
44 O2x O 19.3900 -20.8600
45 C1z C 19.3900 -22.1900
46 C5x C 21.7000 -22.1900
47 C1a C 19.3900 -23.5200
48 C1a C 20.5100 -17.5000
49 O1a O 24.0100 -22.1900
50 O5x O 22.8200 -22.8900
51 C2b C 26.3900 -20.8600
52 N2b N 27.5800 -20.1600
53 N1y N 28.7700 -20.8600
54 C1x C 28.7700 -22.2600
55 C1x C 29.9600 -22.9600
56 N1y N 31.2200 -22.2600
57 C1x C 31.2200 -20.8600
58 C1x C 30.0300 -20.1600
59 C1a C 32.4100 -22.9600
60 Z Na 33.9500 -17.8500
BOND 63
1 1 2 1
2 4 3 1 #Down
3 4 5 1
4 1 5 1
5 6 7 1
6 4 7 1
7 8 9 1
8 9 10 2
9 10 11 1
10 6 11 2
11 7 12 1 #Up
12 5 13 1 #Down
13 1 14 1 #Down
14 9 15 1
15 8 16 2
16 8 17 1
17 2 18 1
18 18 19 1 #Up
19 18 20 1
20 17 21 1
21 21 22 1
22 21 23 2
23 23 24 1
24 24 25 1
25 25 26 1
26 24 27 2
27 27 28 1
28 28 29 2
29 29 30 1
30 25 30 2
31 23 31 1
32 27 32 1
33 2 33 1 #Up
34 19 34 1
35 34 35 1
36 34 36 2
37 26 22 2
38 20 37 1
39 37 38 1 #Down
40 37 39 1
41 20 40 1 #Down
42 38 41 1
43 39 42 2
44 42 43 1
45 29 44 1
46 44 45 1
47 43 45 1
48 30 46 1
49 45 46 1
50 45 47 1 #Down
51 28 48 1
52 26 49 1
53 50 46 2
54 22 51 1
55 51 52 2
56 52 53 1
57 53 54 1
58 54 55 1
59 55 56 1
60 56 57 1
61 57 58 1
62 53 58 1
63 56 59 1
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