KEGG   ORTHOLOGY: K00699
Entry
K00699                      KO                                     
Symbol
UGT
Name
glucuronosyltransferase [EC:2.4.1.17]
Pathway
map00040  Pentose and glucuronate interconversions
map00053  Ascorbate and aldarate metabolism
map00140  Steroid hormone biosynthesis
map00830  Retinol metabolism
map00860  Porphyrin metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01240  Biosynthesis of cofactors
map04976  Bile secretion
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
Module
M00014  Glucuronate pathway (uronate pathway)
M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate
Disease
H00208  Hyperbilirubinemia
H01593  Osteoporosis
H02054  Crigler-Najjar syndrome
H02055  Gilbert syndrome
H02152  Transient familial neonatal hyperbilirubinemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00040 Pentose and glucuronate interconversions
    K00699  UGT; glucuronosyltransferase
   00053 Ascorbate and aldarate metabolism
    K00699  UGT; glucuronosyltransferase
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00699  UGT; glucuronosyltransferase
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K00699  UGT; glucuronosyltransferase
   00860 Porphyrin metabolism
    K00699  UGT; glucuronosyltransferase
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K00699  UGT; glucuronosyltransferase
   00982 Drug metabolism - cytochrome P450
    K00699  UGT; glucuronosyltransferase
   00983 Drug metabolism - other enzymes
    K00699  UGT; glucuronosyltransferase
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K00699  UGT; glucuronosyltransferase
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K00699  UGT; glucuronosyltransferase
   05207 Chemical carcinogenesis - receptor activation
    K00699  UGT; glucuronosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00699  UGT; glucuronosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.17  glucuronosyltransferase
     K00699  UGT; glucuronosyltransferase
Glycosyltransferases [BR:ko01003]
 Others
  Hydrophobic molecule
   K00699  UGT; glucuronosyltransferase
Other DBs
RN: R01383 R02358 R02389 R02478 R02502 R02902 R03091 R04352 R04353 R04354 R04683 R07106 R08259 R08261 R08262 R08263 R08615 R09426 R09427 R09428
GO: 0015020
CAZy: GT1
Genes
HSA: 10720(UGT2B11) 10941(UGT2A1) 54490(UGT2B28) 54575(UGT1A10) 54576(UGT1A8) 54577(UGT1A7) 54578(UGT1A6) 54579(UGT1A5) 54600(UGT1A9) 54657(UGT1A4) 54658(UGT1A1) 54659(UGT1A3) 574537(UGT2A2) 7363(UGT2B4) 7364(UGT2B7) 7365(UGT2B10) 7366(UGT2B15) 7367(UGT2B17) 79799(UGT2A3)
PTR: 100611992 107973969 461285(UGT2B4) 461287 461289 471217 471218(UGT2B7) 471219 471220(UGT2A3) 742890(UGT2A2) 743607
PPS: 100973813 100974387(UGT2B4) 100974709 100975382 100975751 100976704 100977043 100977378 100978938(UGT2A3) 100980327 100980995 100984166 100986642 117979273 117979275 117979276 117979277
GGO: 101133016(UGT2B17) 101133387(UGT2B15) 101135156 101135980 101139531 101140249 101140616 101141374(UGT2B4) 101141727 101145885 101146232 101146584 109026641 115934305 115934311
PON: 100171521(UGT2B7) 100172533(UGT1A3) 100174202(UGT2A3) 100431382 100441531 100444573 100445423 100446313 100446928(UGT2B4) 100447519 100447782(UGT2A1) 100460599(UGT2B17) 100461334
NLE: 100591991 100592283 100595401 100595736 100596311 100596642 100597206 100598804 100599361 100599929 100600348 105738256
MCC: 100427327 106992774 114671445 114678332 574147(UGT2B33) 574210(UGT1A1) 613249(UGT2B9*2) 708989(UGT2B7) 709132 709234 709420(UGT2A3) 710412 718141 720405
MCF: 102118731 102121904 102123935 102124844(UGT2A3) 102126139 102127013 102127901(METTL14) 102128580(UGT2B20) 107126974(UGT1A8) 107126976(UGT1A9) 107126977(UGT1A3) 110006326(UGT1A6) 123567991 123567992
CSAB: 103218110 103218113 103218114 103235585 103235588 103235590 103235708 103235720 103235724
CATY: 105578500 105578518 105596103(UGT2B15) 105596104 105596105 105596174 105596175(UGT2B4) 105596177 105596178(UGT2A3) 105596183(UGT2A1)
PANU: 100126698(UGT1A4) 100126700(UGT1A5A) 100126701(UGT1A1) 100126702(UGT1A6) 100126703(UGT1A9) 100126705(UGT1A7) 100126761(UGT1A5B) 100126762(UGT1A10B) 100337517(UGT2B39) 100337521(UGT2B42) 100337522(UGT2B15) 100337523(UGT2B44) 100337524(UGT2B45) 101010645 101017012 101019271 101020325(UGT2A3)
CJC: 100388812(UGT2A3) 100391186 100405984(UGT1A1) 100409222(UGT2A2) 100412562(UGT2B7) 100414245(UGT2B4) 103792017
MMU: 100559(Ugt2b38) 100727(Ugt2b34) 112417(Ugt2b37) 22236(Ugt1a2) 22238(Ugt2b5) 231396(Ugt2b36) 243085(Ugt2b35) 394430(Ugt1a10) 394432(Ugt1a7c) 394433(Ugt1a5) 394434(Ugt1a9) 394435(Ugt1a6b) 394436(Ugt1a1) 552899(Ugt2a2) 613123(Ugt1a8) 71773(Ugt2b1) 72094(Ugt2a3) 94215(Ugt2a1) 94284(Ugt1a6a)
RNO: 113992(Ugt1a6) 154516(Ugt1a7c) 24861(Ugt1a1) 24862(Ugt2b) 266685(Ugt2b15) 286954(Ugt2b17) 286989(Ugt2b7) 289533(Ugt2a3) 29623(Ugt2b37) 301595(Ugt1a8) 305264(Ugt2b10) 396527(Ugt1a2) 396551(Ugt1a3) 396552(Ugt1a9) 501907(RGD1559459) 574523(Ugt1a5) 63867(Ugt2a1) 83808(Ugt2b35)
FCA: 101087059 101087662 493955(UGT1A1)
PTG: 102959578(UGT1A1) 102967993 102968284(UGT2A1)
BACU: 103008900 103009971(UGT2A3) 103011957(UGT1A3)
LVE: 103071045(UGT1A10) 103071327 103078119(UGT1A1) 103078627 103081112(UGT2B4)
RFQ: 117022250(UGT2A2) 117022636 117022641(UGT2B4) 117025807
GGA: 101749599 101750052 422660(UGT2A1) 424028(UGT1A1)
FPG: 101913401 101923845(UGT1A1) 101924619(UGT2A1)
AMJ: 102558477(UGT1A1) 102568629(UGT2A3)
PBI: 103057215(UGT2A2) 103068173
PMUR: 107286748 107294035(UGT1A1)
PGUT: 117664885 117670781(UGT1A1)
VKO: 123024275
XLA: 100037183(ugt1a6.S) 108701409(ugt1a1.L) 108711396
XTR: 100135191(ugt1a6) 100489505(ugt1a1) 101731695 116406461 447975(ugt2a1)
DRE: 100002993(ugt5e1) 100006320(ugt2a1) 100379286(ugt1a2) 100384891(ugt1a7) 100384893(ugt1b2) 100384895(ugt2b1) 100384896(ugt1a6) 100384897(ugt1a5) 100384898(ugt2b3) 100384899(ugt1b5) 100384901(ugt1a4) 100384902(ugt2b5) 100384903(ugt1b3) 100415791(ugt5b1) 100415792(ugt5b3) 100415794(ugt5d1) 100415797(ugt5a5) 100415798(ugt5a4) 100415799(ugt5b2) 100415800(ugt5f1) 322378(ugt5a3) 406731(ugt1ab) 553952(ugt2a2) 556049(ugt5g2) 558508(ugt1b1) 570913(ugt5g1) 641479(ugt5a1) 641488(ugt1a1) 678597(ugt5b6) 751669(ugt5c2) 767705(ugt2a5) 767756(ugt5a2) 791210(ugt5b4) 791613(ugt2a4) 792506(ugt2b6) 795050(ugt1b4) 795261(ugt1b7) 797211(ugt2a6)
SCLV: 120327972
DME: Dmel_CG10178(Ugt301D1) Dmel_CG11012(Ugt37A1) Dmel_CG11289(Ugt307A1) Dmel_CG13270(Ugt37C2) Dmel_CG13271(Ugt37E1) Dmel_CG15661(Ugt49C1) Dmel_CG15902(Ugt304A1) Dmel_CG17200(Ugt35E1) Dmel_CG17322(Ugt36E1) Dmel_CG17323(Ugt36D1) Dmel_CG17324(Ugt36F1) Dmel_CG17932(Ugt37D1) Dmel_CG2788(Ugt36A1) Dmel_CG31002(Ugt35D1) Dmel_CG3797(Ugt316A1) Dmel_CG4302(Ugt49B1) Dmel_CG4414(Ugt317A1) Dmel_CG4772(Ugt303A1) Dmel_CG5724(Ugt37A2) Dmel_CG5999(Ugt37A3) Dmel_CG6475(Ugt49B2) Dmel_CG6633(Ugt35C1) Dmel_CG6644(Ugt35A1) Dmel_CG6649(Ugt35B1) Dmel_CG6653(Ugt35E2) Dmel_CG6658(Ugt302K1) Dmel_CG8652(Ugt37C1) Dmel_CG9481(Ugt37B1)
DSI: Dsimw501_GD12034(Dsim_GD12034) Dsimw501_GD12307(Dsim_GD12307) Dsimw501_GD16447(Dsim_GD16447) Dsimw501_GD18734(Dsim_GD18734) Dsimw501_GD18859(Dsim_GD18859) Dsimw501_GD19978(Dsim_GD19978) Dsimw501_GD20543(Dsim_GD20543) Dsimw501_GD20680(Dsim_GD20680) Dsimw501_GD20681(Dsim_GD20681) Dsimw501_GD20682(Dsim_GD20682) Dsimw501_GD20683(Dsim_GD20683) Dsimw501_GD20684(Dsim_GD20684) Dsimw501_GD20686(Dsim_GD20686) Dsimw501_GD21706(Dsim_GD21706) Dsimw501_GD23245(Dsim_GD23245) Dsimw501_GD23396(Dsim_GD23396) Dsimw501_GD23454(Dsim_GD23454) Dsimw501_GD24083(Dsim_GD24083) Dsimw501_GD24084(Dsim_GD24084) Dsimw501_GD24158(Dsim_GD24158) Dsimw501_GD24159(Dsim_GD24159) Dsimw501_GD24160(Dsim_GD24160) Dsimw501_GD25117(Dsim_GD25117) Dsimw501_GD25217(Dsim_GD25217) Dsimw501_GD25218(Dsim_GD25218) Dsimw501_GD25513(Dsim_GD25513) Dsimw501_GD27744(Dsim_GD27744) Dsimw501_GD29191(Dsim_GD29191)
BMOR: 100174975(Ugt2) 100216349(Ugt) 100500755(UGT10287A) 100500756(UGT10287B) 100500757(UGT10289B) 100500758(UGT10100) 100500763(UGT10288) 100862802(UGT33D2) 100862803(UGT33D3) 100862804(UGT33D6) 100862805(UGT33K1) 100862806(UGT33N1) 100862807(UGT33Q1) 100862808(UGT33R1) 100862809(UGT340C1) 100862810(UGT340C2) 100862811(UGT39C1) 100862812 100862813 100862814(UGT40B4) 100862815(UGT41A2) 100862816(UGT41A3) 100862817(UGT42A1) 100862818(UGT42A2) 100862819(UGT43B1) 100862820(UGT44A1) 100862821(UGT46A2) 100862822 100862823(UGT47A1) 100862828(UGT013830) 100862830(UGT39B1) 100862841(UGT33D7) 100862842(UGT33R2) 100862843(UGT41A1) 100862845(UGT33D5) 101739741(UGT42B1) 692593(UGT40A1) 732962
CEL: CELE_B0310.5(ugt-46) CELE_C17G1.3(ugt-23) CELE_C18C4.3(ugt-48) CELE_C44H9.1(ugt-15) CELE_F35H8.6(ugt-58) CELE_F39G3.1(ugt-61) CELE_M88.1(ugt-62) CELE_R11A8.3(ugt-59) CELE_T04H1.7(ugt-55) CELE_T04H1.8(ugt-56) CELE_T07C5.1(ugt-50) CELE_ZC443.5(ugt-18) CELE_ZC455.4(ugt-6)
CBR: CBG_00090(Cbr-ugt-50) CBG_00954(Cbr-ugt-58) CBG_01959(Cbr-ugt-23) CBG_08157 CBG_08393(Cbr-ugt-59) CBG_09373(Cbr-ugt-48) CBG_17190(Cbr-ugt-46) CBG_17955 CBG_18047(Cbr-ugt-62) CBG_23423 CBG_23424(Cbr-ugt-56) CBG_27011
BMY: BM_BM17378(Bm17378)
MMER: 123526186
SMIN: v1.2.003055.t1(symbB.v1.2.003055.t1) v1.2.022688.t1(symbB.v1.2.022688.t1) v1.2.023601.t1(symbB.v1.2.023601.t1)
TCR: 510761.76
 » show all
Reference
PMID:3931633
  Authors
Green MD, Falany CN, Kirkpatrick RB, Tephly TR
  Title
Strain differences in purified rat hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase.
  Journal
Biochem J 230:403-9 (1985)
DOI:10.1042/bj2300403
Reference
PMID:9271343
  Authors
Strassburg CP, Oldhafer K, Manns MP, Tukey RH
  Title
Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.
  Journal
Mol Pharmacol 52:212-20 (1997)
DOI:10.1124/mol.52.2.212
  Sequence
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