KEGG   DRUG: Torasemide sodium
Entry
D08619                      Drug                                   

Name
Torasemide sodium;
Torem (TN)
Formula
C16H20N4O3S. xNa
Structure
Simcomp
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01747  Furosemide type diuretic
 DG01748  Loop diuretic
  DG01747  Furosemide type diuretic
Metabolizing enzyme substrate
 DG02918  CYP2C8 substrate
 DG01642  CYP2C9 substrate
Remark
ATC code: C03CA04
Chemical structure group: DG00273
Product (DG00273): D00382<JP/US>
Efficacy
Diuretic, Na-K-Cl cotransporter inhibitor
Comment
Loop diuretic
Sulfonamide derivative
Target
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
SLC12A2 (NKCC1) [HSA:6558] [KO:K10951]
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2C8 [HSA:1558]
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA04 Torasemide
      D08619  Torasemide sodium
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01690  Sulfonamide diuretic
   DG01747  Furosemide type diuretic
    DG00273  Torasemide
     D08619  Torasemide sodium
  DG01748  Loop diuretic
   DG01747  Furosemide type diuretic
    DG00273  Torasemide
     D08619  Torasemide sodium
 Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   DG00273  Torasemide
    D08619  Torasemide sodium
  DG01642  CYP2C9 substrate
   DG00273  Torasemide
    D08619  Torasemide sodium
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D08619  Torasemide sodium
    SLC12A2 (NKCC1)
     D08619  Torasemide sodium
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08619
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01690  Sulfonamide diuretic
   DG01747  Furosemide type diuretic
    DG00273  Torasemide
  DG01748  Loop diuretic
   DG01747  Furosemide type diuretic
    DG00273  Torasemide
 Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   DG00273  Torasemide
  DG01642  CYP2C9 substrate
   DG00273  Torasemide
Other DBs
PubChem: 96025303
LigandBox: D08619
LinkDB
KCF data

ATOM        25
            1   C8y C    26.4600  -20.4400
            2   C8y C    27.6500  -19.7400
            3   S4a S    25.2700  -19.7400
            4   C8x C    26.4600  -21.8400
            5   N1b N    27.6500  -18.3400
            6   C8x C    28.9100  -20.4400
            7   N1b N    24.0100  -20.4400
            8   O3c O    26.2500  -18.7600
            9   O3c O    24.2200  -18.7600
            10  N5x N    27.6500  -22.5400
            11  C8y C    28.8400  -17.6400
            12  C8x C    28.9100  -21.8400
            13  C5a C    22.8200  -19.7400
            14  C8x C    28.8400  -16.2400
            15  C8x C    30.1000  -18.3400
            16  N1b N    21.6300  -20.4400
            17  O5a O    22.8200  -18.3400
            18  C8y C    30.1000  -15.5400
            19  C8x C    31.2900  -17.6400
            20  C1c C    20.3700  -19.7400
            21  C8x C    31.2900  -16.2400
            22  C1a C    30.1000  -14.1400
            23  C1a C    19.1800  -20.4400
            24  C1a C    20.3700  -18.3400
            25  Z   Na   31.5700  -20.7900
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 2
            8     3   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13   11  14 1
            14   11  15 2
            15   13  16 1
            16   13  17 2
            17   14  18 2
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   18  22 1
            22   20  23 1
            23   20  24 1
            24   10  12 2
            25   19  21 2
BRACKET     1    30.8700  -21.7700   30.8700  -20.0900
            1    32.8300  -20.0900   32.8300  -21.7700
            1  x
 ORIGINAL  1   25
 REPEAT    1

» Japanese version   » Back

DBGET integrated database retrieval system