Entry |
|
Name |
Torasemide sodium; Torem (TN) |
Formula |
C16H20N4O3S. xNa
|
Structure |

|
Simcomp |
|
Class |
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01747 Furosemide type diuretic
DG01748 Loop diuretic
DG01747 Furosemide type diuretic
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG01642 CYP2C9 substrate
|
Remark |
Product (DG00273): | D00382<JP/US> |
|
Efficacy |
Diuretic, Na-K-Cl cotransporter inhibitor |
Comment |
Loop diuretic
Sulfonamide derivative
|
Target |
|
Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP2C8 [HSA: 1558]
|
Interaction |
|
Structure map |
map07017 | Sulfonamide derivatives - diuretics |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03C HIGH-CEILING DIURETICS
C03CA Sulfonamides, plain
C03CA04 Torasemide
D08619 Torasemide sodium
Drug groups [BR:br08330]
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01747 Furosemide type diuretic
DG00273 Torasemide
D08619 Torasemide sodium
DG01748 Loop diuretic
DG01747 Furosemide type diuretic
DG00273 Torasemide
D08619 Torasemide sodium
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00273 Torasemide
D08619 Torasemide sodium
DG01642 CYP2C9 substrate
DG00273 Torasemide
D08619 Torasemide sodium
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC12
SLC12A1 (NKCC2)
D08619 Torasemide sodium
SLC12A2 (NKCC1)
D08619 Torasemide sodium
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08619
Drug groups [BR:br08330]
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01747 Furosemide type diuretic
DG00273 Torasemide
DG01748 Loop diuretic
DG01747 Furosemide type diuretic
DG00273 Torasemide
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00273 Torasemide
DG01642 CYP2C9 substrate
DG00273 Torasemide
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Other DBs |
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LinkDB |
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KCF data |
ATOM 25
1 C8y C 26.4600 -20.4400
2 C8y C 27.6500 -19.7400
3 S4a S 25.2700 -19.7400
4 C8x C 26.4600 -21.8400
5 N1b N 27.6500 -18.3400
6 C8x C 28.9100 -20.4400
7 N1b N 24.0100 -20.4400
8 O3c O 26.2500 -18.7600
9 O3c O 24.2200 -18.7600
10 N5x N 27.6500 -22.5400
11 C8y C 28.8400 -17.6400
12 C8x C 28.9100 -21.8400
13 C5a C 22.8200 -19.7400
14 C8x C 28.8400 -16.2400
15 C8x C 30.1000 -18.3400
16 N1b N 21.6300 -20.4400
17 O5a O 22.8200 -18.3400
18 C8y C 30.1000 -15.5400
19 C8x C 31.2900 -17.6400
20 C1c C 20.3700 -19.7400
21 C8x C 31.2900 -16.2400
22 C1a C 30.1000 -14.1400
23 C1a C 19.1800 -20.4400
24 C1a C 20.3700 -18.3400
25 Z Na 31.5700 -20.7900
BOND 25
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 2
8 3 9 2
9 4 10 1
10 5 11 1
11 6 12 1
12 7 13 1
13 11 14 1
14 11 15 2
15 13 16 1
16 13 17 2
17 14 18 2
18 15 19 1
19 16 20 1
20 18 21 1
21 18 22 1
22 20 23 1
23 20 24 1
24 10 12 2
25 19 21 2
BRACKET 1 30.8700 -21.7700 30.8700 -20.0900
1 32.8300 -20.0900 32.8300 -21.7700
1 x
ORIGINAL 1 25
REPEAT 1
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