K10951                      KO                                     
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
map04970  Salivary secretion
map04972  Pancreatic secretion
map05110  Vibrio cholerae infection
H00604  Deafness, autosomal dominant
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09154 Digestive system
   04970 Salivary secretion
    K10951  SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2
   04972 Pancreatic secretion
    K10951  SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K10951  SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K10951  SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K10951  SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K10951  SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2
Transporters [BR:ko02000]
 Solute carrier family (SLC)
  SLC12: Electroneutral cation-coupled Cl cotransporter
   K10951  SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2
Other DBs
GO: 0008511
TC: 2.A.30.1.4 2.A.30.1.5 2.A.30.1.8
HSA: 6558(SLC12A2)
PTR: 471620(SLC12A2)
PPS: 100978438(SLC12A2)
GGO: 101154445(SLC12A2)
PON: 100435387(SLC12A2)
NLE: 100587696(SLC12A2)
MCC: 704672(SLC12A2)
MCF: 101865866(SLC12A2)
CSAB: 103244467(SLC12A2)
CATY: 105599708(SLC12A2)
PANU: 101027028(SLC12A2)
TGE: 112625936(SLC12A2)
RRO: 104659749(SLC12A2)
RBB: 108533166(SLC12A2)
TFN: 117065923(SLC12A2)
PTEH: 111529894(SLC12A2)
CJC: 100393963(SLC12A2)
SBQ: 101043035(SLC12A2)
CSYR: 103271323(SLC12A2)
MMUR: 105857747(SLC12A2)
OGA: 100950465(SLC12A2)
MMU: 20496(Slc12a2)
MCAL: 110284787(Slc12a2)
MPAH: 110332959(Slc12a2)
RNO: 83629(Slc12a2)
MCOC: 116087194(Slc12a2)
MUN: 110546924(Slc12a2)
CGE: 100769027(Slc12a2)
PLEU: 114708374(Slc12a2)
NGI: 103740298(Slc12a2)
HGL: 101705564(Slc12a2)
CPOC: 100714607(Slc12a2)
CCAN: 109702164(Slc12a2)
DORD: 105985123(Slc12a2)
DSP: 122103678(Slc12a2)
NCAR: 124987533
OCU: 100328591(SLC12A2)
OPI: 101533178(SLC12A2)
TUP: 102489962(SLC12A2)
CFA: 481490(SLC12A2)
VVP: 112917101(SLC12A2)
VLG: 121494408(SLC12A2)
AML: 100464321(SLC12A2)
UMR: 103670575(SLC12A2)
UAH: 113261680(SLC12A2)
UAR: 123790392(SLC12A2)
ELK: 111140904
LLV: 125099697
MPUF: 101676823(SLC12A2)
ORO: 101368776(SLC12A2)
EJU: 114209433(SLC12A2)
ZCA: 113928728(SLC12A2)
MLX: 118016595(SLC12A2)
FCA: 101090325(SLC12A2)
PYU: 121010647(SLC12A2)
PBG: 122486999(SLC12A2)
PTG: 102958272(SLC12A2)
PPAD: 109250920(SLC12A2)
AJU: 106970727(SLC12A2)
HHV: 120234736(SLC12A2)
BTA: 286845(SLC12A2)
BOM: 102266898(SLC12A2)
BIU: 109561838(SLC12A2)
BBUB: 102406058(SLC12A2)
CHX: 102173836(SLC12A2)
OAS: 101105242(SLC12A2)
ODA: 120864720(SLC12A2)
CCAD: 122440121(SLC12A2)
SSC: 100516960(SLC12A2)
CFR: 102514596(SLC12A2)
CBAI: 105082082(SLC12A2)
CDK: 105089862(SLC12A2)
VPC: 102529528(SLC12A2)
BACU: 103018624(SLC12A2)
LVE: 103086086(SLC12A2)
OOR: 101281929(SLC12A2)
DLE: 111182386(SLC12A2)
PCAD: 102991629(SLC12A2)
PSIU: 116751805(SLC12A2)
ECB: 100073036(SLC12A2)
EPZ: 103557517(SLC12A2)
EAI: 106842804(SLC12A2)
MYB: 102245247(SLC12A2)
MYD: 102751614(SLC12A2)
MMYO: 118657031(SLC12A2)
MLF: 102438553(SLC12A2)
MNA: 107540912(SLC12A2)
PKL: 118702700(SLC12A2)
HAI: 109379070(SLC12A2)
DRO: 112314975(SLC12A2)
SHON: 118974873(SLC12A2)
AJM: 119043992(SLC12A2)
PDIC: 114512374(SLC12A2)
PHAS: 123818082(SLC12A2)
MMF: 118641926(SLC12A2)
RFQ: 117024716(SLC12A2)
PALE: 102895925(SLC12A2)
PGIG: 120590916(SLC12A2)
PVP: 105290891(SLC12A2)
RAY: 107517865(SLC12A2)
MJV: 108399131(SLC12A2)
TOD: 119243516(SLC12A2)
SARA: 101548929(SLC12A2)
LAV: 100653894(SLC12A2)
TMU: 101342027
DNM: 101411063(SLC12A2)
MDO: 100022720(SLC12A2)
GAS: 123250913(SLC12A2)
SHR: 100913495(SLC12A2)
PCW: 110223814(SLC12A2)
GGA: 427123(SLC12A2)
PCOC: 116238201(SLC12A2)
MGP: 104915239(SLC12A2)
CJO: 107306466(SLC12A2)
NMEL: 110389550(SLC12A2)
APLA: 101799181(SLC12A2)
ACYG: 106045237(SLC12A2)
AFUL: 116501103(SLC12A2)
TGU: 100230871(SLC12A2)
LSR: 110482553(SLC12A2)
SCAN: 103823238(SLC12A2)
PMOA: 120501790(SLC12A2)
OTC: 121335722(SLC12A2)
PRUF: 121351860(SLC12A2)
GFR: 102038932(SLC12A2)
FAB: 101807057(SLC12A2)
PHI: 102109981(SLC12A2)
PMAJ: 107216403(SLC12A2)
CCAE: 111941857(SLC12A2)
CCW: 104691975(SLC12A2)
ETL: 114063868(SLC12A2)
ZAB: 102060519(SLC12A2)
FPG: 101920614(SLC12A2)
FCH: 102048881(SLC12A2)
CLV: 102094035(SLC12A2)
EGZ: 104125072(SLC12A2)
NNI: 104022596(SLC12A2)
ACUN: 113489940(SLC12A2)
TALA: 104359810(SLC12A2)
PADL: 103913221(SLC12A2)
ACHC: 115336594(SLC12A2) 121232943
AROW: 112961624(SLC12A2)
NPD: 112953508(SLC12A2)
DNE: 112992374(SLC12A2)
ASN: 102367935(SLC12A2)
AMJ: 102577309(SLC12A2)
CPOO: 109323466(SLC12A2)
GGN: 109298043(SLC12A2)
PSS: 102450809(SLC12A2)
CMY: 102942372(SLC12A2)
CPIC: 101940224(SLC12A2)
TST: 117879628(SLC12A2)
CABI: 116835599(SLC12A2)
MRV: 120408033(SLC12A2)
ACS: 100555453(slc12a2)
PVT: 110077528(SLC12A2)
SUND: 121922384(SLC12A2)
PBI: 103059397(SLC12A2)
PMUR: 107292308(SLC12A2)
TSR: 106545467(SLC12A2)
PGUT: 117661328(SLC12A2)
VKO: 123031369(SLC12A2)
PMUA: 114606193(SLC12A2)
ZVI: 118076753(SLC12A2)
GJA: 107105772(SLC12A2)
XLA: 100141486(slc12a2.L) 108707193(slc12a2.S)
XTR: 100038244(slc12a2)
NPR: 108795881(SLC12A2)
RTEM: 120932458(SLC12A2)
BBUF: 120988485(SLC12A2)
BGAR: 122924603(SLC12A2)
DRE: 100329477 100537771 415170(slc12a2)
CCAR: 109049253(slc12a2) 109083255
IPU: 108265961 108277086(slc12a2)
PHYP: 113529044 113543507(slc12a2)
SMEO: 124393847(slc12a2) 124399762
TFD: 113655893 113660269(slc12a2)
AMEX: 103036479(slc12a2) 103037139
TRU: 101069002 101074482(slc12a2)
NCC: 104949496
ELY: 117253077 117269707(slc12a2)
PLEP: 121944785 121959654(slc12a2)
SLUC: 116038153(slc12a2) 116054393
ECRA: 117944391 117959439(slc12a2)
PFLV: 114555100 114570479(slc12a2)
GAT: 120830145 120831533(slc12a2)
PPUG: 119224820 119226438(slc12a2)
MSAM: 119891871 119914120(slc12a2)
CUD: 121510067 121524966(slc12a2)
OAU: 116313570 116329323(slc12a2)
OLA: 101167091(slc12a2) 101171840
OML: 112137712 112144156(slc12a2)
XMA: 102220288(slc12a2) 102220392
XCO: 114150241(slc12a2) 114154761
XHE: 116723823(slc12a2) 116730101
PRET: 103470831 103473108(slc12a2)
GAF: 122819682(slc12a2) 122828533
CVG: 107104866(slc12a2)
CTUL: 119773746(slc12a2) 119784864
NFU: 107386185 107390268(slc12a2)
KMR: 108242812 108246461(slc12a2)
ALIM: 106521889 106522216(slc12a2)
NWH: 119413166 119425181(slc12a2)
CSEM: 103389632(slc12a2) 103397992 103398932
POV: 109626194(slc12a2)
SSEN: 122758153(slc12a2) 122768965
HHIP: 117768443 117771878(slc12a2)
SDU: 111221215(slc12a2) 111238553
SLAL: 111645695 111648073(slc12a2)
XGL: 120787517(slc12a2) 120805126
HCQ: 109511667(slc12a2) 109524644
BPEC: 110161613(slc12a2) 110175642
MALB: 109957334 109970915(slc12a2)
SALP: 111961912(slc12a2) 111963819 111975012
ELS: 105021758(slc12a2) 105025383
SFM: 108929915(slc12a2)
PKI: 111861023(slc12a2)
AANG: 118206931
LOC: 102695444(slc12a2)
LCM: 102345349(SLC12A2) 102360278
CMK: 103178048(slc12a2)
RTP: 109935221
BFO: 118409368
BBEL: 109476370
CIN: 100184286
SPU: 577708(SLC12A2)
DME: Dmel_CG31547(NKCC) Dmel_CG4357(Ncc69)
DSI: Dsimw501_GD12726(Dsim_GD12726) Dsimw501_GD19613(Dsim_GD19613)
ZCE: 119839682
HAME: 121868571
PTRU: 123499301
VDE: 111250980
VJA: 111273611
CBR: CBG_15341 CBG_18756(Cbr-nkcc-1)
BMY: BM_BM12714(Bma-nkcc-1)
BGT: 106050963
GAE: 121386365
LAK: 106167063
ATEN: 116288638
DGT: 114520858
HMG: 100198028 100206298(slc12a2)
PIN: Ping_1733
HOH: Hoch_6531
SFU: Sfum_3620
AMR: AM1_1273
CYT: cce_1090
CEO: ETSB_0631
WCH: wcw_0495
SRU: SRU_2259
SRM: SRM_02486(potE)
MLT: VC82_728
MAC: MA_4506
MPY: Mpsy_0084
 » show all
Payne JA, Xu JC, Haas M, Lytle CY, Ward D, Forbush B 3rd
Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon.
J Biol Chem 270:17977-85 (1995)
Hebert SC, Mount DB, Gamba G
Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family.
Pflugers Arch 447:580-93 (2004)

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