KEGG   DRUG: TramadolHelp
Entry
D08623                      Drug                                   

Name
Tramadol (INN);
Amanda (TN)
Formula
C16H25NO2
Exact mass
263.1885
Mol weight
263.3752
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
Same as: C07153
ATC code: N02AX02
Chemical structure group: DG00824
Product (DG00824): D01355<JP/US>
Efficacy
Analgesic, Opioid receptor agonist
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AX Other opioids
     N02AX02 Tramadol
      D08623  Tramadol (INN)
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Tramadol
    D08623  Tramadol (INN)
  Opioid Analgesics, Short-acting
   Tramadol
    D08623  Tramadol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08623  Tramadol (INN)
BRITE hierarchy
Other DBs
CAS: 27203-92-5
PubChem: 96025307
ChEBI: 75725 9648
ChEMBL: CHEMBL1066
DrugBank: DB00193
LigandBox: D08623
NIKKAJI: J244.454B
LinkDB All DBs
KCF data Show

ATOM        19
            1   C1z C    22.4000  -18.6200
            2   C8y C    23.5900  -19.3200
            3   C1y C    22.4000  -17.2200
            4   C1x C    21.1400  -19.3200
            5   O1a O    22.4000  -20.0200
            6   C8x C    24.7800  -18.6200
            7   C8x C    23.5900  -20.7200
            8   C1x C    21.1400  -16.5200
            9   C1b C    23.5900  -16.5200
            10  C1x C    19.9500  -18.6200
            11  C8y C    26.0400  -19.3200
            12  C8x C    24.7800  -21.4200
            13  C1x C    19.9500  -17.2200
            14  N1c N    23.5900  -15.1200
            15  C8x C    26.0400  -20.7200
            16  O2a O    27.2300  -18.6200
            17  C1a C    24.7800  -14.4200
            18  C1a C    22.4000  -14.4200
            19  C1a C    28.4200  -19.3200
BOND        20
            1     1   2 1 #Up
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Down
            9     4  10 1
            10    6  11 1
            11    7  12 2
            12    8  13 1
            13    9  14 1
            14   11  15 2
            15   11  16 1
            16   14  17 1
            17   14  18 1
            18   16  19 1
            19   10  13 1
            20   12  15 1

» Japanese version   » Back

DBGET integrated database retrieval system