KEGG   DRUG: VardenafilHelp
Entry
D08668                      Drug                                   

Name
Vardenafil (INN);
Levitra (TN)
Formula
C23H32N6O4S
Exact mass
488.2206
Mol weight
488.603
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01509  Phosphodiesterase V inhibitor
Remark
ATC code: G04BE09
Chemical structure group: DG00487
Product (DG00487): D03260<JP/US>
Efficacy
Vasodilator, Impotence therapy, Phosphodiesterase V inhibitor
Target
PDE5 [HSA:8654] [KO:K13762]
  Pathway
hsa04022  cGMP-PKG signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BE Drugs used in erectile dysfunction
     G04BE09 Vardenafil
      D08668  Vardenafil (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterase
    PDE5
     D08668  Vardenafil (INN)
BRITE hierarchy
Other DBs
CAS: 224785-90-4
PubChem: 96025351
ChEBI: 46295
ChEMBL: CHEMBL1520
DrugBank: DB00862
PDB-CCD: VDN[PDBj]
LigandBox: D08668
NIKKAJI: J1.662.658I
LinkDB All DBs
KCF data Show

ATOM        34
            1   C8y C    25.4100  -18.6900
            2   C8y C    26.6000  -17.9900
            3   C8y C    25.4100  -20.0900
            4   C8x C    24.1500  -17.9900
            5   N4x N    27.7900  -18.6900
            6   N5x N    26.6000  -16.5900
            7   C8x C    24.1500  -20.7900
            8   O2a O    26.6000  -20.7900
            9   C8y C    22.9600  -18.6900
            10  N4y N    29.0500  -17.9900
            11  C8y C    27.7900  -15.8900
            12  C8x C    22.9600  -20.0900
            13  C1b C    27.7900  -20.0900
            14  S4a S    21.7700  -17.9900
            15  C8y C    29.0500  -16.5900
            16  C8y C    30.3800  -18.4100
            17  O5x O    27.7900  -14.4900
            18  C1a C    28.9800  -20.7900
            19  N1y N    20.5800  -18.6900
            20  O3c O    22.7500  -17.0100
            21  O3c O    20.7900  -17.0100
            22  C8y C    30.3800  -16.1700
            23  N5x N    31.2200  -17.2900
            24  C1b C    30.8000  -19.7400
            25  C1x C    20.5800  -20.0900
            26  C1x C    19.3200  -17.9900
            27  C1a C    30.8000  -14.8400
            28  C1b C    32.1300  -20.0200
            29  C1x C    19.3200  -20.7900
            30  C1x C    18.1300  -18.6900
            31  C1a C    32.5500  -21.3500
            32  N1y N    18.1300  -20.0900
            33  C1b C    16.9400  -20.7900
            34  C1a C    15.7500  -20.0900
BOND        37
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16   11  17 2
            17   13  18 1
            18   14  19 1
            19   14  20 2
            20   14  21 2
            21   15  22 2
            22   16  23 2
            23   16  24 1
            24   19  25 1
            25   19  26 1
            26   22  27 1
            27   24  28 1
            28   25  29 1
            29   26  30 1
            30   28  31 1
            31   29  32 1
            32   32  33 1
            33    9  12 2
            34   11  15 1
            35   22  23 1
            36   30  32 1
            37   33  34 1

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