Entry
Name
Pimavanserin tartrate (USAN); Nuplazide (TN)
Product
Formula
(C25H34FN3O2)2. C4H6O6
Exact mass
1004.5434
Mol weight
1005.19
Structure
Mol file KCF file DB search
Class
Remark
Efficacy
Antiparkinsonian, Antipsychotic
Disease
Comment
Treatment of psychosis in Parkinson's disease patients and in schizophrenia patients
Target
Pathway
hsa04080 Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:
1576 ], CYP3A5 [HSA:
1577 ]; CYP2J2 [HSA:
1573 ], CYP2D6 [HSA:
1565 ]
Interaction
DDI search
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303 ]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AX Other antipsychotics
N05AX17 Pimavanserin
D08969 Pimavanserin tartrate (USAN) <US>
USP drug classification [BR:br08302 ]
Antipsychotics
2nd Generation/Atypical
Pimavanserin
D08969 Pimavanserin tartrate (USAN)
Drug groups [BR:br08330 ]
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
D08969 Pimavanserin tartrate
DG02954 CYP2J2 substrate
D08969 Pimavanserin tartrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D08969 Pimavanserin tartrate
DG02925 CYP3A5 substrate
D08969 Pimavanserin tartrate
Target-based classification of drugs [BR:br08310 ]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR2A
D08969 Pimavanserin tartrate (USAN) <US>
HTR2C
D08969 Pimavanserin tartrate (USAN) <US>
New drug approvals in the USA [br08319.html ]
New molecular entities and new therapeutic biological products
D08969
New drug approvals in the USA, Europe and Japan [br08328.html ]
Approval dates by FDA, EMA and PMDA
D08969
Drug metabolizing enzymes and transporters [br08309.html ]
Drug metabolizing enzymes
D08969
BRITE hierarchy
Other DBs
LinkDB
All DBs
KCF data
Show ATOM 72
1 C8x C 13.5100 -17.7800
2 C8y C 13.5100 -19.1800
3 C8x C 14.7224 -19.8800
4 C8x C 15.9349 -19.1800
5 C8y C 15.9349 -17.7800
6 C8x C 14.7224 -17.0800
7 C1b C 17.1724 -17.0800
8 N1b N 18.3849 -17.7800
9 C5a C 19.5973 -17.0800
10 N1c N 20.8097 -17.7800
11 C1y C 22.0222 -17.0800
12 C1x C 23.2553 -17.7922
13 C1x C 24.4679 -17.0924
14 N1y N 24.4681 -15.6924
15 C1x C 23.2350 -14.9802
16 C1x C 22.0224 -15.6800
17 O5a O 19.5973 -15.6800
18 C1b C 20.8097 -19.1799
19 C8y C 22.0221 -19.8799
20 C8x C 22.0221 -21.2797
21 C8x C 23.2346 -21.9797
22 C8y C 24.4470 -21.2797
23 C8x C 24.4470 -19.8799
24 C8x C 23.2346 -19.1799
25 X F 25.6467 -21.9725
26 C1a C 25.7099 -14.9756
27 O2a O 12.2976 -19.8800
28 C1b C 11.0851 -19.1800
29 C1c C 9.8727 -19.8800
30 C1a C 8.6603 -19.1800
31 C1a C 9.8727 -21.2800
32 O6a O 31.6400 -18.1300
33 C6a C 32.8524 -18.8300
34 C1c C 34.0649 -18.1300
35 C1c C 35.2773 -18.8300
36 C6a C 36.4897 -18.1300
37 O6a O 37.7022 -18.8300
38 O6a O 32.8524 -20.2298
39 O6a O 36.4897 -16.7301
40 O1a O 34.0649 -16.7302
41 O1a O 35.2773 -20.2300
42 C8x C 13.5100 -17.7800
43 C8y C 13.5100 -19.1800
44 C8x C 14.7224 -19.8800
45 C8x C 15.9349 -19.1800
46 C8y C 15.9349 -17.7800
47 C8x C 14.7224 -17.0800
48 C1b C 17.1724 -17.0800
49 N1b N 18.3849 -17.7800
50 C5a C 19.5973 -17.0800
51 N1c N 20.8097 -17.7800
52 C1y C 22.0222 -17.0800
53 C1x C 23.2553 -17.7922
54 C1x C 24.4679 -17.0924
55 N1y N 24.4681 -15.6924
56 C1x C 23.2350 -14.9802
57 C1x C 22.0224 -15.6800
58 C1a C 25.7099 -14.9756
59 C1b C 20.8097 -19.1799
60 C8y C 22.0221 -19.8799
61 C8x C 22.0221 -21.2797
62 C8x C 23.2346 -21.9797
63 C8y C 24.4470 -21.2797
64 C8x C 24.4470 -19.8799
65 C8x C 23.2346 -19.1799
66 X F 25.6467 -21.9725
67 O5a O 19.5973 -15.6800
68 O2a O 12.2976 -19.8800
69 C1b C 11.0851 -19.1800
70 C1c C 9.8727 -19.8800
71 C1a C 8.6603 -19.1800
72 C1a C 9.8727 -21.2800
BOND 75
1 32 33 1
2 33 34 1
3 34 35 1
4 35 36 1
5 36 37 1
6 33 38 2
7 36 39 2
8 34 40 1 #Down
9 35 41 1 #Down
10 1 2 2
11 2 3 1
12 3 4 2
13 4 5 1
14 5 6 2
15 1 6 1
16 5 7 1
17 7 8 1
18 8 9 1
19 9 10 1
20 10 11 1
21 11 12 1
22 12 13 1
23 13 14 1
24 14 15 1
25 15 16 1
26 11 16 1
27 9 17 2
28 10 18 1
29 18 19 1
30 19 20 2
31 20 21 1
32 21 22 2
33 22 23 1
34 23 24 2
35 19 24 1
36 22 25 1
37 14 26 1
38 2 27 1
39 27 28 1
40 28 29 1
41 29 30 1
42 29 31 1
43 42 43 2
44 43 44 1
45 44 45 2
46 45 46 1
47 46 47 2
48 42 47 1
49 46 48 1
50 48 49 1
51 49 50 1
52 50 51 1
53 51 52 1
54 52 53 1
55 53 54 1
56 54 55 1
57 55 56 1
58 56 57 1
59 52 57 1
60 50 67 2
61 51 59 1
62 59 60 1
63 60 61 2
64 61 62 1
65 62 63 2
66 63 64 1
67 64 65 2
68 60 65 1
69 63 66 1
70 55 58 1
71 43 68 1
72 68 69 1
73 69 70 1
74 70 71 1
75 70 72 1
BRACKET 1 6.1600 -22.4000 6.1600 -12.7400
1 27.3700 -12.7400 27.3700 -22.4000
1 2
ORIGINAL 1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
1 26 18 19 20 21 22 23 24 25 17 27 28 29 30 31
REPEAT 1 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57
1 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72