KEGG   DRUG: ConatumumabHelp
Entry
D09329                      Drug                                   

Name
Conatumumab (USAN/INN)
Formula
C6466H10006N1730O2024S40
Exact mass
145554.2053
Mol weight
145643.6104
Sequence
(Heavy chain) QVQLQESGPG LVKPSQTLSL TCTVSGGSIS SGDYFWSWIR
QLPGKGLEWI GHIHNSGTTY YNPSLKSRVT ISVDTSKKQF SLRLSSVTAA DTAVYYCARD
RGGDYYYGMD VWGQGTTVTV SSASTKGPSV FPLAPSSKST SGGTAALGCL VDKYFPEPVT
VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKRV
EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF
NWYVDGVEVH NAKTKPREEQ YNSTYRVVSVLTVLHQDWLN GKEYKCKVSN KALPAPIEKT
ISKAKGQPRE PQVYTLPPSR EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP
PVLDSDGSFF LYSKLTVDLS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
(Dimer: H231-H'231; H234-H'234,  Disulfide brige: 22-97; 49-205; 266-326; 372-430, Glycosylation site: 302)
(Light chain) EIVLTQSPGT LSLSPGERAT LSCRASQGIS RSYLAWYQQK
PGQAPSLLIY GASSRATGIP DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QFGSSPWTFG
QGTKVEIKRT VAAPSVFIFP PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS
QESVTEQDSK DSTYLSSTL TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide brige: 23-89; 135-195; H225-L215; H'225-L'215, Dimer)
  Type
Peptide
Efficacy
Antineoplastic, TRAIL receptor 2 agonist
Comment
Monoclonal antibody
Target
TNFRSF10B (TRAILR2, CD262) [HSA:8795] [KO:K04722]
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    TNFRSF10B (TRAILR2, CD262)
     D09329  Conatumumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 896731-82-1
PubChem: 96026009
LinkDB All DBs

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