KEGG ORTHOLOGY: K04722

ORTHOLOGY: K04722

Entry

K04722                      KO

Symbol

TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2

Name

tumor necrosis factor receptor superfamily member 10A/B

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04115

p53 signaling pathway

map04210

Apoptosis

map04217

Necroptosis

map04650

Natural killer cell mediated cytotoxicity

map05130

Pathogenic Escherichia coli infection

map05132

Salmonella infection

map05164

Influenza A

map05417

Lipid and atherosclerosis

Disease

H02610

Head and neck squamous cell carcinoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
   04061 Viral protein interaction with cytokine and cytokine receptor
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
   04217 Necroptosis
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
   04115 p53 signaling pathway
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
   05132 Salmonella infection
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
   04090 CD molecules
    K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
Cytokine receptors [BR:ko04050]
Tumor necrosis factor receptors
  TNF receptor superfamily
   K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
CD molecules [BR:ko04090]
Proteins
  K04722  CD261, TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a
  K04722  CD262, TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b

Other DBs

GO:	0005031 0045569

Genes

HSA:	8795(TNFRSF10B) 8797(TNFRSF10A)

PTR:	742898(TNFRSF10B) 743159(TNFRSF10A)

PPS:	100971044(TNFRSF10A) 100973227(TNFRSF10B)

GGO:	101141415(TNFRSF10B) 101146659(TNFRSF10A)

PON:	100460763(TNFRSF10B) 100461502(TNFRSF10A)

NLE:	100602881(TNFRSF10A) 105740159(TNFRSF10B)

HMH:	116461997(TNFRSF10B) 116462001(TNFRSF10A)

MCC:	716650(TNFRSF10B) 716826(TNFRSF10A)

MCF:	102133727(TNFRSF10B) 102139560(TNFRSF10A)

MTHB:

126961267 126961271

MNI:	105482067(TNFRSF10B) 105482149

CSAB:

103215469(TNFRSF10B) 103215472(TNFRSF10A)

CATY:

105579211(TNFRSF10A) 105579216(TNFRSF10B)

PANU:

101002483(TNFRSF10B) 101004108(TNFRSF10A)

TGE:	112630107(TNFRSF10A) 112630735(TNFRSF10B)

MLEU:

105531023(TNFRSF10B) 105531054(TNFRSF10A)

RRO:	104663979(TNFRSF10B) 104663984(TNFRSF10A)

RBB:	108537955(TNFRSF10A) 108540791(TNFRSF10B)

TFN:	117093403(TNFRSF10A) 117093430(TNFRSF10B)

PTEH:

111545697(TNFRSF10B) 111545701(TNFRSF10A)

CANG:

105510193(TNFRSF10A) 105510195(TNFRSF10B)

CJC:	100395977(TNFRSF10A) 100397065 100397442(TNFRSF10B)

SBQ:	101042934(TNFRSF10B) 101045196(TNFRSF10A)

CIMI:

108318569(TNFRSF10A) 108318570(TNFRSF10B)

MMUR:

105857120 105857162 105867538 105872888 105879846

LCAT:

123626450 123630454

PCOQ:

105807185 105825241 105826925

OGA:

100960488

MMU:	21933(Tnfrsf10b)

MCAL:

110309833

MPAH:

110325978(Tnfrsf10b)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

121458468 121464404 121464411

AAMP:

119799946

NGI:

108491686

HGL:	101697353(Tnfrsf10b)

CPOC:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

TUP:	102489149 102497170

GVR:	103592524(TNFRSF10A) 103609839

CFA:

VLG:

NPO:

AML:

UMR:

ELK:

MNP:

MLK:

NVS:

EJU:

ZCA:

LWW:

FCA:

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	104968444 784541

BIU:

109563119

BBIS:

104984204 104994580

CHX:	102175959 108634850 108635411 108635488 108638455 108638473

BTAX:

128052079 128052097 128052227

ODA:	120865773 120867706

CCAD:

122432087 122432089

MBEZ:

129556896

SSC:	100624226 100737977

CFR:	102505260 106730027 116660778

CBAI:

105068968 105069037

CDK:	105102505 105102515

VPC:	107033437 116286113

BACU:

103003908 103004545 103017407

BMUS:

118897348 118897349

LVE:	103075576 103076248 103089274(TNFRSF10A)

OOR:

101271509

DLE:	111185435(TNFRSF10A) 111185436

PCAD:

102979472 102980036

PSIU:

116756118 116756119

NASI:

112401433 112401434(TNFRSF10A)

ECB:	100057812(TNFRSF10B) 102149226 102150834

EPZ:	103552761(TNFRSF10B)

EAI:	106826120 106847693 123275602

MYB:	102253175(TNFRSF10B)

MYD:	102751782(TNFRSF10B)

MMYO:

118648977 118649099 118658901(TNFRSF10B)

MLF:	102424229(TNFRSF10A)

EFUS:

103295138(TNFRSF10B)

MNA:	107536102 107540363

DRO:	112305008 112317424

SHON:

118975062

AJM:	119041884 119054722

PDIC:

PHAS:

MMF:

PPAM:

HAI:	109372325(TNFRSF10A) 109389286

RFQ:	117038097 117038099

PALE:

102887459(TNFRSF10B)

PGIG:

120606644 120606646

PVP:	105296657(TNFRSF10B)

RAY:	107503231 107509196 107509211 107509212 107509214

MJV:

108393208

TOD:	119233979(TNFRSF10A)

SARA:

101537204(TNFRSF10B)

SETR:

126004388

LAV:	104846102 104846103

TMU:

101348450

DNM:	101438083(TNFRSF10B)

MDO:	103100524(TNFRSF10A)

GAS:	123233411(TNFRSF10A)

SHR:

105749071

PCW:	110197185 110200403

OAA:	103166210 103166465 103169510

GGA:	373904(TNFRSF10B)

PCOC:

116238399 116242973

MGP:	100539605 664712(TNFRSF10B)

CJO:	107314696 107323583

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:	100231625 115498199

LSR:	110468677 110480329

SCAN:

PMOA:

OTC:

PRUF:

GFR:	102032130 102033914

FAB:	101816790(TNFRSF10A) 101820140

OMA:

130261979

PHI:	102101117 102103547

PMAJ:

107205625 107213952

CCAE:

111930789 111938818

CCW:	104686638 104694835

CBRC:

103614954

ETL:

114069860

ZAB:

102071440

SVG:	106863437(TNFRSF10B)

MMEA:

130587541

HRT:

120764013

FPG:	101919474(TNFRSF10A)

FCH:

102053169

CLV:

102094994

EGZ:

104123536

NNI:	104019542(TNFRSF10B)

PCRI:

PLET:

EHS:

ACUN:

TALA:

AFOR:

ACHC:

HLE:	104828839(TNFRSF10B)

AGEN:

GCL:

CCRI:

CMAC:

BREG:

FGA:

GSTE:

104258706(TNFRSF10B)

MNB:

OHA:

SHAB:

DPUB:

CPEA:

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:	106485705 106496997

AROW:

112972388 112973657

NPD:	112949785(TNFRSF10B)

DNE:	112978952 112996667

SCAM:

104147536

ASN:	102368783 102378076(TNFRSF10B)

AMJ:	102562497(TNFRSFA) 106737553(TNFRSF10B)

CPOO:

109320749 109324568

GGN:	109288405 109299155

PSS:	102458875 102462633

CMY:	102937275 102943585

CCAY:

125626404 125638618

DCC:	119848738 119857266

CPIC:

101944874 101954090

TST:	117872959 117877281

CABI:

116816362 116836889

MRV:	120397671 120403085

ACS:	100559769 103281217(tnfrsf10b)

ASAO:

132782492

PVT:	110072186 110076554

SUND:

121935055

PBI:	103057498 103064527

PMUR:

107292942 114923592

TSR:	106548010 106551579

APRI:

131185579 131203786

PTEX:

113440268 113445604 113445648

NSS:	113412558 113420992

VKO:

123026999

PMUA:

114585615 114598952

PRAF:

128402596 128416205

ZVI:	118087838 118097137

HCG:	128333513 128340731

GJA:	107107289(TNFRSF10B) 107124146

STOW:

125441986

EMC:	129325179 129342362(TNFRSF10B)

XLA:	404688(tnfrsf10b.L)

XTR:	448240(tnfrsf10b)

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	373093(hdr)

SRX:	107709863 107721544 107737861

SANH:

107659287 107673363 107686911

SGH:	107594999 107595685

CCAR:

109053926 109068071

CAUA:

113038706 113049429

CGIB:

127958284

PTET:

122345579(hdr)

LROH:

127164951(hdr)

OMC:	131540649(hdr)

PPRM:

120470427(hdr)

MAMB:

125266505(hdr)

CIDE:

127512245

MASI:

127420274

TROS:

130567379(hdr)

TDW:	130419415(hdr)

MANU:

129440098(hdr)

IPU:	108255678(hdr) 108279174(tnfrsfa)

IFU:	128625619(hdr)

PHYP:

113535740 113542228

SMEO:

124380370(hdr)

TFD:	113639514(hdr)

TVC:	132855067(hdr)

AMEX:

103025853 103030935

CMAO:

118827384(hdr)

EEE:	113568408 113576923

CHAR:

105889954(hdr)

TRU:	101068795 101073992

TFS:	130517329(tnfrsfa) 130526430(hdr)

LCO:	104936786 104939559

NCC:

104946837

TBEN:

117476599(tnfrsfa) 117489094

CGOB:

115013448 115017084

PGEO:

117444879 117456180(tnfrsfa)

GACU:

117538258 117562217(tnfrsfa)

EMAC:

134868224(tnfrsfa)

ELY:	117253214(hdr) 117269833(tnfrsfa)

EFO:	125890552(hdr) 125905745(tnfrsfa)

PLEP:

121944916(hdr) 121959704(tnfrsfa)

SLUC:

116047668(hdr) 116063023(tnfrsfa)

ECRA:

117944776(hdr) 117959828(tnfrsfa)

ESP:	116688942 116704227

PFLV:

114556405 114571241

GAT:	120831152(hdr) 120831568(tnfrsfa)

PPUG:

119225593(hdr) 119227063

AFB:	129101714 129102291

CLUM:

117735912(hdr) 117740781(tnfrsfa)

PSWI:

130196354 130205306(tnfrsfa)

MSAM:

119892131(hdr) 119914185(tnfrsfa) 119918688

SCHU:

122865611 122876352(hdr)

CUD:	121510319(hdr) 121525059(tnfrsfa)

ALAT:

119019251(hdr) 119030076(tnfrsfa)

MZE:	101465040 101466428

ONL:	100697530 100706660

OAU:	116310481(tnfrsfa) 116321102(hdr)

OLA:	101172833 101173230

OML:	112148678(hdr) 112163478

CSAI:

133451456(hdr) 133455098(tnfrsfa)

XMA:	102220811 102221406

XCO:	114149417 114154314

XHE:	116724216 116730146

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122827092(hdr) 122847240(tnfrsfa)

PPRL:

129351621(hdr) 129374293(tnfrsfa)

CVG:	107092852 107094654 107104273

CTUL:

119773219(tnfrsfa) 119791261

GMU:	124872613 124877166(hdr)

NFU:	107374098 107374869

KMR:	108242614(tnfrsfa) 108247039

ALIM:

106513113 106537247

NWH:	119413681 119424839(tnfrsfa)

AOCE:

111566190 111583694

MCEP:

124996629

CSEM:

103390031 103398930

POV:	109626051 109633911

SSEN:

122758445(tnfrsfa) 122770034(hdr)

HHIP:

117768556(hdr) 117768557 117771545(tnfrsfa)

HSP:	118115530(hdr) 118125828(tnfrsfa)

SMAU:

118284772(tnfrsfa) 118314143(hdr)

LCF:	108878624(hdr) 108895430(tnfrsfa)

SDU:	111230580 111239057

SLAL:

111648042 111666828

XGL:	120805095(hdr) 120806581(tnfrsfa)

HCQ:	109525037 109526039

SSCV:

125965720 125979541

SBIA:

133490628 133499378(hdr)

PEE:	133400324(hdr) 133414193(tnfrsfa)

PTAO:

133474766(hdr) 133490291(tnfrsfa)

BPEC:

110157351 110172395

MALB:

109959755 109969775

BSPL:

114845540 114866892(tnfrsfa)

SJO:	128364981(hdr) 128380553(tnfrsfa)

SASA:

106563139 106567553 106580524 106584955

STRU:

115159678 115164264 115200388 115203974

OTW:	112220324 112230781 112248682(hdr) 112265338

OMY:	110509702 110523488(tnfrsfa) 110525895(hdr) 110536280

OGO:	124007074 124033239 124036510 124049049

ONE:	115111061 115121617 115140265 115147151

OKI:	109868307 109872299 109873941 109896106

OKE:	118358506 118385498 118387455(tnfrsfa) 118394251(hdr)

SALP:

111961715 111963941 111974358 112069851

SNH:	120020971 120026441 120051484(hdr) 120063362

CCLU:

121530677 121541591 121582607 121584213(hdr)

ELS:	105014382 105015154

SFM:	108925009 108940401

PKI:	111847083 111857576

AANG:

118206564(hdr) 118213458

LOC:

102683981

PSPA:

121301381 121303083

ARUT:

117966494

LCM:	102361530 102366259 102366681

HOC:

132826121

PMRN:

116956968

BBEL:

109475980 109476343

BGT:	106057358 106057362

HRF:

124115064

HRJ:	124281777 124283958

CVN:	111122671 111127020

CANU:

MYI:

PMAX:

ADF:

XEN:

Reference

PMID:9285725

Authors

Screaton GR, Mongkolsapaya J, Xu XN, Cowper AE, McMichael AJ, Bell JI

Title

TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL.

Journal

Curr Biol 7:693-6 (1997)
DOI:10.1016/S0960-9822(06)00297-1

Sequence

[hsa:8795]

Reference

PMID:9082980

Authors

Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM

Title

The receptor for the cytotoxic ligand TRAIL.

Journal

Science 276:111-3 (1997)
DOI:10.1126/science.276.5309.111

Sequence

[hsa:8797]

LinkDB

DBGET integrated database retrieval system