KEGG   DRUG: FidaxomicinHelp
Entry
D09394                      Drug                                   

Name
Fidaxomicin (JAN/USAN);
Dificid (TN);
Dificlir (TN)
Product
Formula
C52H74Cl2O18
Exact mass
1056.4252
Mol weight
1058.0392
Structure
Mol fileKCF fileDB search
Class
Antibacterial
 DG01551  Macrolide antibiotic
Cyp inhibitor
 DG01933  CYP2C19 inhibitor
 DG01522  CYP3A4 inhibitor
Unclassified
 DG02852  CYP3A inhibitor
  DG01522  CYP3A4 inhibitor
Remark
ATC code: A07AA12
Product: D09394<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Comment
Treatment of Clostridium difficile-associated diarrhea (CDAD)
Target
Peptoclostridium difficile rpoB [KO:K03043]
Peptoclostridium difficile rpoC [KO:K03046]
Interaction
CYP inhibition: CYP2C19 [HSA:1557], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA12 Fidaxomicin
      D09394  Fidaxomicin (JAN/USAN) <US>
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Fidaxomicin
    D09394  Fidaxomicin (JAN/USAN)
Antiinfectives [br08350.html]
 Antibacterials
  D09394
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09394
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09394
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09394
BRITE hierarchy
Other DBs
CAS: 873857-62-6
PubChem: 96026074
ChEBI: 68590
LigandBox: D09394
LinkDB All DBs
KCF data Show

ATOM        72
            1   C1y C    19.2500  -39.1300
            2   C2x C    19.2500  -40.5300
            3   C2y C    20.4624  -41.2300
            4   C1y C    21.6749  -40.5300
            5   C2y C    21.6749  -39.1300
            6   C1y C    20.4624  -38.4300
            7   C1x C    22.8873  -41.2300
            8   C2x C    24.0997  -40.5300
            9   C2y C    24.0997  -39.1300
            10  C2x C    22.8873  -38.4300
            11  C2x C    25.3122  -41.2300
            12  C2x C    26.5246  -40.5300
            13  C1x C    26.5246  -39.1300
            14  C2x C    25.3122  -38.4300
            15  C2y C    27.7370  -41.2300
            16  C7x C    28.9495  -40.5300
            17  O7x O    28.9495  -39.1300
            18  C1y C    27.7370  -38.4300
            19  C1a C    20.4624  -42.6298
            20  C1a C    21.6851  -37.7301
            21  C1a C    24.0997  -37.7300
            22  C1c C    27.7370  -37.0300
            23  O1a O    28.9366  -36.3373
            24  C1a C    26.5119  -36.3226
            25  O6a O    30.1846  -41.2434
            26  C1b C    27.7370  -42.6300
            27  O2a O    28.9367  -43.3226
            28  C1y C    30.1491  -44.0226
            29  C1y C    30.1490  -45.4298
            30  C1y C    31.3614  -46.1299
            31  C1y C    32.5739  -45.4300
            32  C1y C    32.5740  -44.0228
            33  O2x O    31.3616  -43.3227
            34  C1a C    33.7653  -43.3350
            35  O2a O    28.9523  -46.1208
            36  C1a C    27.7647  -45.4350
            37  O1a O    31.3613  -47.5300
            38  O7a O    33.7682  -46.1199
            39  C7a C    34.9552  -45.4348
            40  C8y C    36.1465  -46.1229
            41  O6a O    34.9555  -44.0302
            42  C8y C    36.1463  -47.5298
            43  C8y C    37.3586  -48.2299
            44  C8y C    38.5712  -47.5301
            45  C8y C    38.5714  -46.1233
            46  C8y C    37.3590  -45.4231
            47  C1b C    34.9141  -48.2412
            48  C1a C    33.7089  -47.5453
            49  X   Cl   37.3584  -49.6298
            50  O1a O    39.7826  -48.2297
            51  X   Cl   39.7800  -45.4257
            52  O1a O    37.3593  -44.0302
            53  O1a O    20.6850  -39.5401
            54  C1b C    18.0376  -38.4300
            55  C1a C    16.8421  -39.1204
            56  O2a O    20.4624  -37.0302
            57  C1y C    20.4624  -35.6302
            58  O2x O    21.6580  -34.9397
            59  C1z C    21.6578  -33.5397
            60  C1y C    20.4453  -32.8398
            61  C1y C    19.2497  -33.5303
            62  C1y C    19.2499  -34.9303
            63  O1a O    18.0377  -35.6303
            64  O1a O    18.0373  -32.8305
            65  C1a C    22.8532  -32.8490
            66  C1a C    22.8453  -34.2251
            67  O7a O    20.4452  -31.4300
            68  C7a C    19.2288  -30.7279
            69  O6a O    18.0315  -31.4194
            70  C1c C    19.2287  -29.3302
            71  C1a C    18.0322  -28.6394
            72  C1a C    20.4570  -28.6207
BOND        75
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     5   6 1
            5     1   6 1
            6     4   7 1
            7     7   8 1
            8     9  10 1
            9     5  10 2
            10    8  11 2
            11   11  12 1
            12   13  14 1
            13    9  14 2
            14   12  15 2
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   13  18 1
            19    3  19 1
            20    5  20 1
            21    9  21 1
            22   18  22 1
            23   22  23 1 #Up
            24   22  24 1
            25   16  25 2
            26   15  26 1
            27   26  27 1
            28   28  27 1 #Down
            29   28  29 1
            30   29  30 1
            31   30  31 1
            32   31  32 1
            33   32  33 1
            34   28  33 1
            35   32  34 1 #Down
            36   29  35 1 #Down
            37   35  36 1
            38   30  37 1 #Down
            39   31  38 1 #Up
            40   38  39 1
            41   39  40 1
            42   39  41 2
            43   40  42 2
            44   42  43 1
            45   43  44 2
            46   44  45 1
            47   45  46 2
            48   40  46 1
            49   42  47 1
            50   47  48 1
            51   43  49 1
            52   44  50 1
            53   45  51 1
            54   46  52 1
            55    4  53 1 #Up
            56    1  54 1 #Down
            57   54  55 1
            58    6  56 1 #Up
            59   56  57 1
            60   57  58 1
            61   58  59 1
            62   59  60 1
            63   60  61 1
            64   61  62 1
            65   57  62 1
            66   62  63 1 #Up
            67   61  64 1 #Up
            68   59  65 1
            69   59  66 1
            70   60  67 1 #Down
            71   67  68 1
            72   68  69 2
            73   68  70 1
            74   70  71 1
            75   70  72 1

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