| Entry |
|
|---|
| Name |
Ezogabine (USAN);
Retigabine (INN);
Potiga (TN)
|
|---|
| Formula |
C16H18FN3O2
|
|---|
| Exact mass |
303.1383
|
|---|
| Mol weight |
303.3314
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG02037 GABA mimetic antiepileptics
Transporter inhibitor
DG01622 ABCB1 (P-GP) inhibitor
DG02866 SLC22A8 (OAT3) inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antiepileptic |
|---|
| Comment |
Adjunctive therapy for partial onset seizures
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
Transporter inhibition: SLC22A8 [HSA: 9376], ABCB1 [HSA: 5243]
|
|---|
| Structure map |
| map07232 | Potassium channel blocking and opening drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AX Other antiepileptics
N03AX21 Retigabine
D09569 Ezogabine (USAN)
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Potassium channels
KCNQ
D09569 Ezogabine (USAN)
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D09569
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D09569
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D09569
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D09569
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 22
1 C8x C 17.0100 -26.2500
2 C8y C 17.0100 -27.6500
3 C8x C 18.2700 -28.3500
4 C8x C 19.4600 -27.6500
5 C8y C 19.4600 -26.2500
6 C8x C 18.2700 -25.5500
7 C1b C 20.6500 -25.5500
8 N1b N 21.9100 -26.2500
9 C8y C 23.1000 -25.5500
10 C8x C 24.2900 -26.2500
11 C8y C 25.5500 -25.5500
12 C8y C 25.5500 -24.1500
13 C8x C 24.2900 -23.4500
14 C8x C 23.1000 -24.1500
15 N1b N 26.7400 -23.4500
16 C7a C 27.9300 -24.1500
17 O7a O 29.1900 -23.4500
18 C1b C 30.3800 -24.1500
19 C1a C 31.5700 -23.4500
20 O6a O 27.9300 -25.5500
21 N1a N 26.7400 -26.2500
22 X F 15.8200 -28.3500
BOND 23
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 1
10 9 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 13 14 2
15 9 14 1
16 12 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 16 20 2
22 11 21 1
23 2 22 1
|
|---|
