KEGG   DRUG: EzogabineHelp
Entry
D09569                      Drug                                   

Name
Ezogabine (USAN);
Retigabine (INN);
Potiga (TN)
Product
Formula
C16H18FN3O2
Exact mass
303.1383
Mol weight
303.3314
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02037  GABA mimetic antiepileptics
Transporter inhibitor
 DG01622  ABCB1 (P-GP) inhibitor
 DG02866  SLC22A8 (OAT3) inhibitor
Remark
Same as: C13826
ATC code: N03AX21
Product: D09569<US>
Efficacy
Antiepileptic
Comment
Adjunctive therapy for partial onset seizures
Target
  Pathway
hsa04725  Cholinergic synapse
Interaction
Transporter inhibition: SLC22A8 [HSA:9376], ABCB1 [HSA:5243]
Drug interaction
Structure map
map07232  Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX21 Retigabine
      D09569  Ezogabine (USAN) <US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Anticonvulsants, Other
   Ezogabine
    D09569  Ezogabine (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Potassium channels
    KCNQ
     D09569  Ezogabine (USAN) <US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09569
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09569
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09569
BRITE hierarchy
Other DBs
CAS: 150812-12-7
PubChem: 124490309
ChEBI: 68584
ChEMBL: CHEMBL41355
LigandBox: D09569
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8x C    17.0100  -26.2500
            2   C8y C    17.0100  -27.6500
            3   C8x C    18.2700  -28.3500
            4   C8x C    19.4600  -27.6500
            5   C8y C    19.4600  -26.2500
            6   C8x C    18.2700  -25.5500
            7   C1b C    20.6500  -25.5500
            8   N1b N    21.9100  -26.2500
            9   C8y C    23.1000  -25.5500
            10  C8x C    24.2900  -26.2500
            11  C8y C    25.5500  -25.5500
            12  C8y C    25.5500  -24.1500
            13  C8x C    24.2900  -23.4500
            14  C8x C    23.1000  -24.1500
            15  N1b N    26.7400  -23.4500
            16  C7a C    27.9300  -24.1500
            17  O7a O    29.1900  -23.4500
            18  C1b C    30.3800  -24.1500
            19  C1a C    31.5700  -23.4500
            20  O6a O    27.9300  -25.5500
            21  N1a N    26.7400  -26.2500
            22  X   F    15.8200  -28.3500
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   12  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   16  20 2
            22   11  21 1
            23    2  22 1

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