KEGG   DRUG: Briakinumab
Entry
D09588                      Drug                                   
Name
Briakinumab (USAN/INN)
Formula
C6376H9874N1722O1992S44
Exact mass
143845.1989
Mol weight
143933.91
Sequence
(Heavy chain)
QVQLVESGGG VVQPGRSLRL SCAASGFTFS SYGMHWVRQA PGKGLEWVAF IRYDGSNKYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCKTHG SHDNWGQGTM VTVSSASTKG
PSVFPLAPSS KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL
SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KKVEPKSCDK THTCPPCPAP ELLGGPSVFL
FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV
VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSREEMTKNQ
VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV
FSCSVMHEAL HNHYTQKSLS LSPGK
(Light chain)
QSVLTQPPSV SGAPGQRVTI SCSGSRSNIG SNTVKWYQQL PGTAPKLLIY YNDQRPSGVP
DRFSGSKSGT SASLAITGLQ AEDEADYYCQ SYDRYTHPAL LFGTGTKVTV LGQPKAAPSV
TLFPPSSEEL QANKATLVCL ISDFYPGAVT VAWKADSSPV KAGVETTTPS KQSNNKYAAS
SYLSLTPEQW KSHRSYSCQV THEGSTVEKT VAPTECS
(Disulfide bridge: H22-H96, H142-H198, H259-H319, H65-H423, H224-H'224, H227-H'227, L22-L89, L139-L198, H218-L216)
  Type
Peptide
Class
Immunological agent
 DG02019  Interleukin inhibitor
Remark
ATC code: L04AC09
Efficacy
Anti-inflammatory, Immunosuppressant, Anti-IL12/23 antibody
  Type
Bispecific antibody
Target
IL12 [HSA:3592 3593] [KO:K05406 K05425]
IL23A [HSA:51561] [KO:K05426]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC09 Briakinumab
      D09588  Briakinumab (USAN/INN)
Drug groups [BR:br08330]
 Immunological agent
  DG02019  Interleukin inhibitor
   D09588  Briakinumab
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL12
     D09588  Briakinumab (USAN/INN)
    IL23A
     D09588  Briakinumab (USAN/INN)
Other DBs
CAS: 339308-60-0
PubChem: 124490328
LinkDB

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