Homo sapiens (human): 3592
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Entry
3592 CDS
T01001
Symbol
IL12A, CLMF, IL-12A, NFSK, NKSF1, P35
Name
(RefSeq) interleukin 12A
KO
K05406
interleukin 12A
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04620
Toll-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04936
Alcoholic liver disease
hsa04940
Type I diabetes mellitus
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05143
African trypanosomiasis
hsa05144
Malaria
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05162
Measles
hsa05164
Influenza A
hsa05168
Herpes simplex virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05321
Inflammatory bowel disease
hsa05330
Allograft rejection
hsa05417
Lipid and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06183
Yersinia
nt06219
JAK-STAT signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06266
Non-small cell lung cancer
nt06276
Chronic myeloid leukemia
nt06517
TLR signaling
nt06518
JAK-STAT signaling
Element
N00053
Cytokine-Jak-STAT signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N01307
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01557
IL12/23 to Jak-STAT signaling pathway
N01566
TLR5-NFKB signaling pathway
Drug target
Apilimod mesylate:
D06556
Briakinumab:
D09588
Lisofylline:
D04748
Ustekinumab:
D09214
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
3592 (IL12A)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
3592 (IL12A)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3592 (IL12A)
04622 RIG-I-like receptor signaling pathway
3592 (IL12A)
04625 C-type lectin receptor signaling pathway
3592 (IL12A)
04658 Th1 and Th2 cell differentiation
3592 (IL12A)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3592 (IL12A)
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
3592 (IL12A)
05164 Influenza A
3592 (IL12A)
05162 Measles
3592 (IL12A)
05168 Herpes simplex virus 1 infection
3592 (IL12A)
09171 Infectious disease: bacterial
05133 Pertussis
3592 (IL12A)
05134 Legionellosis
3592 (IL12A)
05152 Tuberculosis
3592 (IL12A)
09174 Infectious disease: parasitic
05146 Amoebiasis
3592 (IL12A)
05144 Malaria
3592 (IL12A)
05145 Toxoplasmosis
3592 (IL12A)
05140 Leishmaniasis
3592 (IL12A)
05142 Chagas disease
3592 (IL12A)
05143 African trypanosomiasis
3592 (IL12A)
09163 Immune disease
05321 Inflammatory bowel disease
3592 (IL12A)
05330 Allograft rejection
3592 (IL12A)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3592 (IL12A)
09167 Endocrine and metabolic disease
04940 Type I diabetes mellitus
3592 (IL12A)
04936 Alcoholic liver disease
3592 (IL12A)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
3592 (IL12A)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
3592 (IL12A)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Interleukins
3592 (IL12A)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Cytokines
3592 (IL12A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IL12
Motif
Other DBs
NCBI-GeneID:
3592
NCBI-ProteinID:
NP_000873
OMIM:
161560
HGNC:
5969
Ensembl:
ENSG00000168811
Pharos:
P29459
(Tclin)
UniProt:
P29459
O60595
Structure
PDB
PDBj
LinkDB
All DBs
Position
3:159988835..159996019
Genome browser
AA seq
253 aa
AA seq
DB search
MWPPGSASQPPPSPAAATGLHPAARPVSLQCRLSMCPARSLLLVATLVLLDHLSLARNLP
VATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACL
PLELTKNESCLNSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLL
MDPKRQIFLDQNMLAVIDELMQALNFNSETVPQKSSLEEPDFYKTKIKLCILLHAFRIRA
VTIDRVMSYLNAS
NT seq
762 nt
NT seq
+upstream
nt +downstream
nt
atgtggccccctgggtcagcctcccagccaccgccctcacctgccgcggccacaggtctg
catccagcggctcgccctgtgtccctgcagtgccggctcagcatgtgtccagcgcgcagc
ctcctccttgtggctaccctggtcctcctggaccacctcagtttggccagaaacctcccc
gtggccactccagacccaggaatgttcccatgccttcaccactcccaaaacctgctgagg
gccgtcagcaacatgctccagaaggccagacaaactctagaattttacccttgcacttct
gaagagattgatcatgaagatatcacaaaagataaaaccagcacagtggaggcctgttta
ccattggaattaaccaagaatgagagttgcctaaattccagagagacctctttcataact
aatgggagttgcctggcctccagaaagacctcttttatgatggccctgtgccttagtagt
atttatgaagacttgaagatgtaccaggtggagttcaagaccatgaatgcaaagcttctg
atggatcctaagaggcagatctttctagatcaaaacatgctggcagttattgatgagctg
atgcaggccctgaatttcaacagtgagactgtgccacaaaaatcctcccttgaagaaccg
gatttttataaaactaaaatcaagctctgcatacttcttcatgctttcagaattcgggca
gtgactattgatagagtgatgagctatctgaatgcttcctaa
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