KEGG   DRUG: Siltuximab
Entry
D09669                      Drug                                   
Name
Siltuximab (USAN/INN);
Sylvant (TN)
Product
SYLVANT (EUSA Pharma (UK))
Formula
C6450H9932N1688O2016S50
Exact mass
144891.2586
Mol weight
144981.2251
Sequence
(Heavy chain)
EVQLVESGGK LLKPGGSLKL SCAASGFTFS SFAMSWFRQS PEKRLEWVAE ISSGGSYTYY
PDTVTGRFTI SRDNAKNTLY LEMSSLRSED TAMYYCARGL WGYYALDYWG QGTSVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Light chain)
QIVLIQSPAI MSASPGEKVT MTCSASSSVS YMYWYQQKPG SSPRLLIYDT SNLASGVPVR
FSGSGSGTSY SLTISRMEAE DAATYYCQQW SGYPYTFGGG TKLEIKRTVA APSVFIFPPS
DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE SVTEQDSKDS TYSLSSTLTL
SKADYEKHKV YACEVTHQGL SSPVTKSFNR GEC
(Disulfide bridge: H22-H96, H146-H202, H263-H323, H369-H427, H228-H'228, H231-H'231, L23-L87, L133-L193, H222-L213)
  Type
Peptide
Class
Immunological agent
 DG02019  Interleukin inhibitor
Remark
ATC code: L04AC11
Product: D09669<US>
Efficacy
Immunomodulator, Anti-IL-6 antibody
  Disease
Castleman's disease [DS:H01479]
  Type
Monoclonal antibody
Target
IL6 [HSA:3569] [KO:K05405]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC11 Siltuximab
      D09669  Siltuximab (USAN/INN) <US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunological Agents, Other
   Interleukin Blockers
    Siltuximab
     D09669  Siltuximab (USAN/INN)
Drug groups [BR:br08330]
 Immunological agent
  DG02019  Interleukin inhibitor
   D09669  Siltuximab
Drug classes [BR:br08332]
 Immunological agent
  DG02019  Interleukin inhibitor
   D09669  Siltuximab
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL6
     D09669  Siltuximab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09669
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09669
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09669
Other DBs
CAS: 541502-14-1
PubChem: 124490409
LinkDB

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