KEGG ORTHOLOGY: K05405

ORTHOLOGY: K05405

Entry

K05405                      KO

Symbol

IL6

Name

interleukin 6

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01523

Antifolate resistance

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04066

HIF-1 signaling pathway

map04068

FoxO signaling pathway

map04151

PI3K-Akt signaling pathway

map04218

Cellular senescence

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04625

C-type lectin receptor signaling pathway

map04630

JAK-STAT signaling pathway

map04640

Hematopoietic cell lineage

map04657

IL-17 signaling pathway

map04659

Th17 cell differentiation

map04668

TNF signaling pathway

map04672

Intestinal immune network for IgA production

map04931

Insulin resistance

map04932

Non-alcoholic fatty liver disease

map04933

AGE-RAGE signaling pathway in diabetic complications

map04936

Alcoholic liver disease

map05010

Alzheimer disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05130

Pathogenic Escherichia coli infection

map05132

Salmonella infection

map05133

Pertussis

map05134

Legionellosis

map05135

Yersinia infection

map05142

Chagas disease

map05143

African trypanosomiasis

map05144

Malaria

map05146

Amoebiasis

map05152

Tuberculosis

map05161

Hepatitis B

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05321

Inflammatory bowel disease

map05323

Rheumatoid arthritis

map05332

Graft-versus-host disease

map05410

Hypertrophic cardiomyopathy

map05417

Lipid and atherosclerosis

Disease

H00084

Graft-versus-host disease

H00286

Crohn disease

H00630

Rheumatoid arthritis

H01479

Castleman disease

H01672

Juvenile idiopathic arthritis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05405  IL6; interleukin 6
   04668 TNF signaling pathway
    K05405  IL6; interleukin 6
   04066 HIF-1 signaling pathway
    K05405  IL6; interleukin 6
   04068 FoxO signaling pathway
    K05405  IL6; interleukin 6
   04151 PI3K-Akt signaling pathway
    K05405  IL6; interleukin 6
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05405  IL6; interleukin 6
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05405  IL6; interleukin 6
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K05405  IL6; interleukin 6
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05405  IL6; interleukin 6
   04620 Toll-like receptor signaling pathway
    K05405  IL6; interleukin 6
   04621 NOD-like receptor signaling pathway
    K05405  IL6; interleukin 6
   04623 Cytosolic DNA-sensing pathway
    K05405  IL6; interleukin 6
   04625 C-type lectin receptor signaling pathway
    K05405  IL6; interleukin 6
   04659 Th17 cell differentiation
    K05405  IL6; interleukin 6
   04657 IL-17 signaling pathway
    K05405  IL6; interleukin 6
   04672 Intestinal immune network for IgA production
    K05405  IL6; interleukin 6
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05405  IL6; interleukin 6
   05202 Transcriptional misregulation in cancer
    K05405  IL6; interleukin 6
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05405  IL6; interleukin 6
   05161 Hepatitis B
    K05405  IL6; interleukin 6
   05171 Coronavirus disease - COVID-19
    K05405  IL6; interleukin 6
   05164 Influenza A
    K05405  IL6; interleukin 6
   05162 Measles
    K05405  IL6; interleukin 6
   05168 Herpes simplex virus 1 infection
    K05405  IL6; interleukin 6
   05163 Human cytomegalovirus infection
    K05405  IL6; interleukin 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05405  IL6; interleukin 6
   05169 Epstein-Barr virus infection
    K05405  IL6; interleukin 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05405  IL6; interleukin 6
   05132 Salmonella infection
    K05405  IL6; interleukin 6
   05135 Yersinia infection
    K05405  IL6; interleukin 6
   05133 Pertussis
    K05405  IL6; interleukin 6
   05134 Legionellosis
    K05405  IL6; interleukin 6
   05152 Tuberculosis
    K05405  IL6; interleukin 6
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05405  IL6; interleukin 6
   05144 Malaria
    K05405  IL6; interleukin 6
   05142 Chagas disease
    K05405  IL6; interleukin 6
   05143 African trypanosomiasis
    K05405  IL6; interleukin 6
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05405  IL6; interleukin 6
   05321 Inflammatory bowel disease
    K05405  IL6; interleukin 6
   05332 Graft-versus-host disease
    K05405  IL6; interleukin 6
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K05405  IL6; interleukin 6
   05020 Prion disease
    K05405  IL6; interleukin 6
   05022 Pathways of neurodegeneration - multiple diseases
    K05405  IL6; interleukin 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05405  IL6; interleukin 6
   05410 Hypertrophic cardiomyopathy
    K05405  IL6; interleukin 6
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05405  IL6; interleukin 6
   04932 Non-alcoholic fatty liver disease
    K05405  IL6; interleukin 6
   04931 Insulin resistance
    K05405  IL6; interleukin 6
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05405  IL6; interleukin 6
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05405  IL6; interleukin 6
   01523 Antifolate resistance
    K05405  IL6; interleukin 6
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05405  IL6; interleukin 6
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interleukins
   K05405  IL6; interleukin 6

Other DBs

GO:

0005138

Genes

HSA:

3569(IL6)

PTR:	463288(IL6)

PPS:	100967827(IL6)

GGO:	101151687(IL6)

PON:	100453941(IL6)

NLE:	100586527(IL6)

HMH:	116813186(IL6)

MCC:	705819(IL6)

MCF:	102138971(IL6)

MTHB:

126950025

MNI:	105475680(IL6)

CSAB:

103226390(IL6)

CATY:

105595383(IL6)

PANU:

100381195(IL6)

TGE:	112621592(IL6)

MLEU:

105534984(IL6)

RRO:	104675233(IL6)

RBB:	108529326(IL6)

TFN:	117072793(IL6)

PTEH:

111545050(IL6)

CANG:

105513330(IL6)

CJC:	100393440(IL6)

SBQ:	101034757(IL6)

CIMI:

108303199(IL6)

CSYR:

103268608(IL6)

MMUR:

105875882(IL6)

LCAT:

123646908(IL6)

PCOQ:

105822445(IL6)

OGA:	100949231(IL6)

MMU:	16193(Il6)

MCAL:

110295330(Il6)

MPAH:

110317140(Il6)

RNO:	24498(Il6)

MCOC:

116097436(Il6)

ANU:	117720807(Il6)

MUN:	110539463(Il6)

CGE:	100689186(Il6)

MAUA:

101839443(Il6)

PROB:

127235558(Il6)

PLEU:

114689756(Il6)

MORG:

121439902(Il6)

MFOT:

126491159

AAMP:

119808459(Il6)

NGI:	103740849(Il6)

HGL:	101702602(Il6)

CPOC:

106027696(Il6)

CCAN:

109679557(Il6)

DORD:

105991375(Il6)

DSP:	122112101 122112102 122112217

NCAR:

124990183

MMMA:

107146026(Il6)

OCU:	100008733(IL6)

OPI:	101531329(IL6)

TUP:	102490996 102496137(IL6) 106733357 106733358 106733575 106733746 106734037 106734038 106734039

GVR:	103585928(IL6)

CFA:	403985(IL6)

CLUD:

112670562(IL6)

VVP:	112915865(IL6)

VLG:	121474963(IL6)

NPO:	129502880(IL6)

AML:	100477151(IL6) 117803984

UMR:	103658871(IL6)

UAH:	113261280(IL6)

UAR:	123788681(IL6)

ELK:

111147365

LLV:

125081177

MPUF:

101671465(IL6)

MNP:	132015023(IL6)

MLK:	131829493(IL6)

NVS:	122904064(IL6)

ORO:	101377851(IL6)

EJU:	114221211(IL6)

ZCA:	113911910(IL6)

MLX:	118020856(IL6)

NSU:	110580018(IL6)

LWW:	102745902(IL6)

FCA:	493687(IL6)

PYU:	121028638(IL6)

PCOO:

112866659(IL6)

PBG:	122487989(IL6)

PVIV:

125152182(IL6)

LRUF:

124524718

PTG:	102968780(IL6)

PPAD:

109263814(IL6)

PUC:

125930836

AJU:

106982277

HHV:	120236228(IL6)

BTA:	280826(IL6)

BOM:	102287919(IL6)

BIU:	109558077(IL6)

BBUB:

102415101(IL6)

BBIS:

104987936(IL6)

CHX:	100860785(IL6)

OAS:	443406(IL6)

BTAX:

128046952(IL6)

ODA:	120878073(IL6)

CCAD:

122438196(IL6)

SSC:	399500(IL6)

CFR:	102515320(IL6)

CBAI:

105079801(IL6)

CDK:	105095065(IL6)

VPC:	102529729(IL6)

BACU:

103008558(IL6)

BMUS:

118900814(IL6)

LVE:	103081545(IL6)

OOR:	101281783(IL6)

DLE:	111181978(IL6)

PCAD:

102980126(IL6)

PSIU:

116759822(IL6)

NASI:

112395338(IL6)

ECB:	100034196(IL6)

EPZ:	103561141(IL6)

EAI:	106824372(IL6)

MYB:	102243367(IL6)

MYD:	102760336(IL6)

MMYO:

118666134(IL6)

MLF:	102431882(IL6)

PKL:	118714203(IL6)

EFUS:

103292051(IL6)

MNA:	107540295(IL6)

DRO:	112306851(IL6)

AJM:	119042560(IL6)

PDIC:

114508090(IL6)

PHAS:

123811876(IL6)

MMF:	118620458(IL6)

PPAM:

129063428(IL6)

HAI:	109387871(IL6)

RFQ:	117012414(IL6)

PALE:

102895746(IL6)

PGIG:

120602335(IL6)

PVP:	105293152(IL6)

RAY:	107518120(IL6)

MJV:	108398622(IL6)

TOD:	119243289(IL6)

SARA:

101540363(IL6)

LAV:	100660846(IL6)

TMU:

101351590

ETF:	101644240(IL6) 123522712

DNM:	101429481 101443963(IL6)

MDO:	103104339(IL6)

GAS:	123255152(IL6)

SHR:	105750762(IL6)

PCW:	110213115(IL6)

OAA:	100083298(IL6)

GGA:	395337(IL6)

PCOC:

116227028(IL6)

MGP:	100548599(IL6)

CJO:	107309150(IL6)

TPAI:

128085831(IL6)

LMUT:

125695972(IL6)

NMEL:

110394224(IL6)

APLA:

101798321(IL6)

ACYG:

106030150(IL6)

CATA:

118255869(IL6)

AFUL:

116486491(IL6)

TGU:	100220682(IL6)

LSR:	110474585(IL6)

SCAN:

103813132(IL6)

PMOA:

120501209(IL6)

OTC:	121339595(IL6)

PRUF:

121353190(IL6)

GFR:	102040265(IL6)

FAB:	101806545(IL6)

OMA:	130248751(IL6)

PHI:	102109522(IL6)

PMAJ:

107215587(IL6)

CCAE:

111924309(IL6)

CCW:	104689316(IL6)

CBRC:

103613552(IL6)

ETL:	114063967(IL6)

ZAB:	102065743(IL6)

ACHL:

103797180(IL6)

SVG:	106863974(IL6)

MMEA:

130584730(IL6)

HRT:	120751263(IL6)

FPG:	101911163(IL6)

FCH:	102047657(IL6)

CLV:	102097240(IL6)

EGZ:	104126108(IL6)

NNI:	104013985(IL6)

PLET:

104615743(IL6)

EHS:	104517166(IL6)

PCAO:

104042564(IL6)

ACUN:

113476314(IL6)

TALA:

104367691(IL6)

PADL:

103918452(IL6)

AFOR:

103901234(IL6)

ACHC:

115339802(IL6)

HALD:

104319966(IL6)

HLE:	104838075(IL6)

AGEN:

126037943

GCL:

127013522

CCRI:

104156476(IL6)

CSTI:

104552073(IL6)

CMAC:

104475791(IL6)

MUI:	104535351(IL6)

BREG:

104634214(IL6)

FGA:	104076983(IL6)

LDI:	104345065(IL6)

MNB:	103776824(IL6)

OHA:	104326589(IL6)

NNT:	104411997(IL6)

SHAB:

115607542(IL6)

DPUB:

104307634(IL6)

PGUU:

104459984(IL6)

CPEA:

104397654(IL6)

AVIT:

104269024(IL6)

CVF:	104281556(IL6)

RTD:	128905108(IL6)

CUCA:

104068044(IL6)

TEO:	104371132(IL6)

BRHI:

104488697(IL6)

AAM:	106483538(IL6)

AROW:

112974163(IL6)

NPD:	112942428(IL6)

DNE:	112986051(IL6)

SCAM:

104145141(IL6)

ASN:	102377828(IL6)

AMJ:	102567649(IL6)

CPOO:

109307916(IL6)

GGN:	109291522(IL6)

PSS:	102450313(IL6)

CMY:	102935916(IL6)

CCAY:

125631011(IL6)

DCC:	119851076(IL6)

CPIC:

101951588(IL6)

TST:	117871704(IL6)

CABI:

116831337(IL6)

MRV:	120398388(IL6)

ACS:	103279135(il6)

ASAO:

132779144(IL6)

PVT:	110073207(IL6)

SUND:

121935009(IL6)

PBI:	103067562(IL6)

PMUR:

107282781(IL6)

CTIG:

120307373(IL6)

PGUT:

117655168(IL6)

APRI:

131197508(IL6)

PTEX:

113440061(IL6)

NSS:	113418902(IL6)

VKO:	123033826(IL6)

PMUA:

114593429 114593430 114607734(IL6)

PRAF:

128424368(IL6)

ZVI:	118092352(IL6)

HCG:	128331359(IL6)

GJA:	107116125(IL6)

STOW:

125440811(IL6)

EMC:	129337334(IL6)

XLA:	108718487(il6.L)

XTR:	100493927(il6)

NPR:

108797293

RTEM:

120940157(IL6)

BBUF:

121002283(IL6)

BGAR:

122939048(IL6)

MUO:	115471029(IL6)

GSH:	117354071(IL6)

DRE:	100885851(il6)

SRX:

107755962

SANH:

107667573 107704752

SGH:	107570916 107571360

CCAR:

109055884

CAUA:

113062448 113069455 113119662 113119663

CGIB:

127935925 127979671

PTET:

122335307(il6)

LROH:

127182390(il6)

OMC:	131525177(il6)

PPRM:

120483438 120483439

RKG:	130069051(il6)

MAMB:

125276183(il6)

CIDE:

127501686

MASI:

127420890 127425535

TROS:

130567230(il6)

TDW:	130415247(il6)

MANU:

129455845(il6)

IPU:

108257494

IFU:	128600806(il6)

PHYP:

113536255 113536325

SMEO:

124376403(il6)

TFD:	113661640(il6)

TVC:	132837483(il6)

AMEX:

111191914

CMAO:

118806159(il6)

CHAR:

116225031

TRU:	503562(il-6)

TFS:

130518667

TNG:	GSTEN00003507G001

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

116066855(il6)

ECRA:

117956362(il6)

ESP:

PFLV:

GAT:

PPUG:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OML:

CVG:

CTUL:

GMU:

NFU:

NWH:

AOCE:

CSEM:

POV:

SSEN:

HHIP:

HSP:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SBIA:

133495334(il6)

PEE:

PTAO:

BPEC:

MALB:

SJO:

SASA:

106570581(IL6) 106588787

STRU:

115173233 115175363

OTW:	112235861(il6) 112264462

OMY:	100136689(il6) 110496949

OGO:	124013382 124042693(il6)

ONE:	115117812 115119806

OKI:	109880070 109908688

OKE:	118371869 118372807(il6)

SALP:

112068887 112071421

SNH:	120022750 120041044(il6)

CCLU:

121573028(il6) 121585646

ELS:

105012469

SFM:	108933304(il6)

PKI:	111846921(il6)

AANG:

118234251

LOC:	107078662(il6)

PSPA:

121315084(il6)

ARUT:

117394993(il6)

LCM:	102347088(IL6)

CMK:	103185303(il6)

RTP:	109925317(il6) 109925335 125485471

CPLA:

122550242 122550281(il6)

HOC:	132815932(il6)

LERI:

129705909 129712701(il6)

» show all

Reference

PMID:19189867

Authors

Fonseca JE, Santos MJ, Canhao H, Choy E

Title

Interleukin-6 as a key player in systemic inflammation and joint destruction.

Journal

Autoimmun Rev 8:538-42 (2009)
DOI:10.1016/j.autrev.2009.01.012

Reference

PMID:3500852

Authors

Yasukawa K, Hirano T, Watanabe Y, Muratani K, Matsuda T, Nakai S, Kishimoto T

Title

Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.

Journal

EMBO J 6:2939-45 (1987)
DOI:10.1002/j.1460-2075.1987.tb02598.x

Sequence

[hsa:3569]

LinkDB

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