KEGG   DRUG: TafamidisHelp
Entry
D09673                      Drug                                   

Name
Tafamidis (USAN/INN);
Vyndaqel (TN)
Formula
C14H7Cl2NO3
Exact mass
306.9803
Mol weight
308.1163
Structure
Mol fileKCF fileDB search
Remark
ATC code: N07XX08
Chemical structure group: DG01009
Product (DG01009): D09674<JP>
Efficacy
Amyloidogenesis suppressant
Comment
Tafamidis stabilizes tetrameric form of the transthyretin [HSA:7276]
Treatment of transthyretin-associated amyloidosis
Target
TTR [HSA:7276] [KO:K20731]
  Pathway
hsa04918  Thyroid hormone synthesis
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07X OTHER NERVOUS SYSTEM DRUGS
    N07XX Other nervous system drugs
     N07XX08 Tafamidis
      D09673  Tafamidis (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Other transporters
   Transthyretin
    TTR
     D09673  Tafamidis (USAN/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09673
BRITE hierarchy
Other DBs
CAS: 594839-88-0
PubChem: 124490413
ChEBI: 78538
ChEMBL: CHEMBL2103837
PDB-CCD: 3MI[PDBj]
LigandBox: D09673
LinkDB All DBs
KCF data Show

ATOM        20
            1   C8y C    22.8900  -27.3000
            2   C8y C    22.8900  -28.7000
            3   C8x C    24.1024  -29.4000
            4   C8x C    25.3149  -28.7000
            5   C8y C    25.3149  -27.3000
            6   C8x C    24.1024  -26.6000
            7   O2x O    21.5585  -26.8674
            8   C8y C    20.7356  -28.0000
            9   N5x N    21.5585  -29.1326
            10  C8y C    19.3200  -28.0000
            11  C6a C    26.5460  -26.5890
            12  O6a O    27.7512  -27.2847
            13  O6a O    26.5457  -25.2001
            14  C8x C    18.6200  -26.7876
            15  C8y C    17.2200  -26.7876
            16  C8x C    16.5200  -28.0000
            17  C8y C    17.2200  -29.2124
            18  C8x C    18.6200  -29.2124
            19  X   Cl   16.5296  -25.5921
            20  X   Cl   16.5296  -30.4079
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 2
            10    2   9 1
            11    8  10 1
            12    5  11 1
            13   11  12 1
            14   11  13 2
            15   10  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   10  18 2
            21   15  19 1
            22   17  20 1

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