KEGG   DRUG: AnagliptinHelp
Entry
D09780                      Drug                                   

Name
Anagliptin (JAN/INN)
Formula
C19H25N7O2
Exact mass
383.207
Mol weight
383.4475
Structure
Mol fileKCF fileDB search
Class
Antidiabetic agent
 DG01601  DPP-4 inhibitor
 DG02044  Hypoglycemics
  DG01601  DPP-4 inhibitor
Remark
Therapeutic category: 3969
Product: D09780<JP>
Product (mixture): D11109<JP>
Efficacy
Antidiabetic, Dipeptidyl peptidase-4 (DPP-4) inhibitor
  Disease
Type 2 diabetes mellitus [DS:H00409]
Target
DPP4 (CD26) [HSA:1803] [KO:K01278]
  Pathway
hsa04974  Protein digestion and absorption
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D09780  Anagliptin (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-peptidases
    DPP4 (CD26)
     D09780  Anagliptin (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09780
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09780
BRITE hierarchy
Other DBs
CAS: 739366-20-2
PubChem: 124490520
ChEMBL: CHEMBL1929396
PDB-CCD: SKK[PDBj]
LigandBox: D09780
LinkDB All DBs
KCF data Show

ATOM        28
            1   N5x N    31.6229  -19.5173
            2   C8y C    31.6229  -20.9164
            3   N4y N    30.4337  -21.6159
            4   C8x C    29.1745  -20.9164
            5   C8y C    29.1745  -19.5173
            6   C8x C    30.4337  -18.8178
            7   C5a C    27.9853  -18.8178
            8   N1b N    26.7961  -19.5173
            9   O5a O    27.9853  -17.4187
            10  C8x C    32.6722  -21.8258
            11  C8y C    32.1126  -23.1549
            12  N5x N    30.7135  -23.0150
            13  C1a C    32.8121  -24.3441
            14  C1b C    25.6069  -18.8178
            15  C1d C    24.4176  -19.5173
            16  N1b N    23.2284  -18.8178
            17  C1a C    23.3683  -20.4966
            18  C1a C    25.3970  -20.4966
            19  C1b C    22.0391  -19.5173
            20  C5a C    20.8499  -18.8178
            21  N1y N    19.6607  -19.5173
            22  O5a O    20.8499  -17.4187
            23  C1x C    19.2410  -20.8464
            24  C1x C    17.8419  -20.8464
            25  C1x C    17.3522  -19.5173
            26  C1y C    18.4715  -18.6779
            27  C3b C    18.4715  -17.2788
            28  N3a N    18.4715  -15.8797
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     5   7 1
            8     7   8 1
            9     7   9 2
            10    2  10 2
            11   10  11 1
            12   11  12 2
            13    3  12 1
            14   11  13 1
            15    8  14 1
            16   14  15 1
            17   15  16 1
            18   15  17 1
            19   15  18 1
            20   16  19 1
            21   19  20 1
            22   20  21 1
            23   20  22 2
            24   21  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   21  26 1
            29   26  27 1 #Up
            30   27  28 3

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