KEGG   DRUG: TopiroxostatHelp
Entry
D09786                      Drug                                   

Name
Topiroxostat (JAN/INN);
Uriadec (TN)
Formula
C13H8N6
Exact mass
248.081
Mol weight
248.2428
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01503  Xanthine dehydrogenase inhibitor
Remark
Therapeutic category: 3949
Product: D09786<JP>
Efficacy
Gout suppressant, Uric acid biosynthesis inhibitor, Xanthine oxidase inhibitor
Target
XDH [HSA:7498] [KO:K00106]
  Pathway
hsa00230  Purine metabolism
hsa00232  Caffeine metabolism
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   394  Gout preparations
    3949  Others
     D09786  Topiroxostat (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Xanthine dehydrogenase/oxidase
    XDH
     D09786  Topiroxostat (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09786
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09786
BRITE hierarchy
Other DBs
CAS: 577778-58-6
PubChem: 124490526
ChEMBL: CHEMBL1078685
PDB-CCD: FYX[PDBj]
LigandBox: D09786
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8x C    18.9000  -19.9500
            2   N5x N    18.9000  -21.3500
            3   C8y C    20.1124  -22.0500
            4   C8x C    21.3249  -21.3500
            5   C8y C    21.3249  -19.9500
            6   C8x C    20.1124  -19.2500
            7   C3b C    20.1124  -23.4498
            8   N3a N    20.1124  -24.8498
            9   C8y C    22.5560  -19.2390
            10  N5x N    23.8865  -19.6332
            11  C8y C    24.6750  -18.4888
            12  N4x N    23.8302  -17.3852
            13  N5x N    22.5197  -17.8477
            14  C8y C    26.1097  -18.4531
            15  C8x C    26.8519  -19.6672
            16  C8x C    28.2515  -19.7022
            17  N5x N    28.9209  -18.4026
            18  C8x C    28.1787  -17.1884
            19  C8x C    26.7791  -17.2235
BOND        21
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     3   7 1
            8     7   8 3
            9     5   9 1
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 1
            14    9  13 2
            15   11  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   14  19 1

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