KEGG   DRUG: DrozitumabHelp
Entry
D09888                      Drug                                   

Name
Drozitumab (USAN/INN)
Formula
C6334H9792N1700O2000S42
Exact mass
143014.5047
Mol weight
143102.4423
Sequence
(Heavy chain) EVQLVQSGGG VERPGGSLRL SCAASGFTFD DYAMSWVRQA
PGKGLEWVSG INWQGGSTGY ADSVKGRVTI SRDNAKNSLY LQMNSLRAED TAVYYCAKIL
GAGRGWYFDY WGKGTTVTVS SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV
SWNSGALTSG VHTFPAVLQS SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDKKVE
PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN
WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI
SKAKGQPREP QVYTLPPSRE EMTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP
VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG K
(Disulfide bridge: 22-96; 148-204; 265-325; 371-429, Dimer: 230; 233)
(Light chain) SELTQDPAVS VALGQTVRIT CSGDSLRSYY ASWYQQKPGQ
APVLVIYGAN NRPSGIPDRF SGSSSGNTAS LTITGAQAED EADYYCNSAD SSGNHVVFGG
GTKLTVLGQP KAAPSVTLFP PSSEELQANK ATLVCLISDF YPGAVTVAWK ADSSPVKAGV
ETTTPSKQSN NKYAASSYLS LTPEQWKSHK SYSCQVTHEG STVEKTVAPT ECS
(Disulfide bridge: 21-86; 135-194, H2244-L212, Dimer)
  Type
Peptide
Efficacy
Antineoplastic, Anti-TRAIL receptor 2 antibody
Comment
Monoclonal antibody
Target
TNFRSF10B (TRAILR2, CD262) [HSA:8795] [KO:K04722]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04115  p53 signaling pathway
hsa04210  Apoptosis
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    TNFRSF10B (TRAILR2, CD262)
     D09888  Drozitumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 912628-39-8
PubChem: 124490605
LinkDB All DBs

» Japanese version   » Back

DBGET integrated database retrieval system