KEGG   DRUG: Trelagliptin succinate
Entry
D10179                      Drug                                   
Name
Trelagliptin succinate (JAN/USAN);
Zafatek (TN)
Formula
C18H20FN5O2. C4H6O4
Exact mass
475.1867
Mol weight
475.4701
Structure
Simcomp
Class
Antidiabetic agent
 DG02044  Hypoglycemic agent
  DG01601  DPP-4 inhibitor
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 3969
Chemical structure group: DG01284
Product (DG01284): D10179<JP>
Efficacy
Antidiabetic, Dipeptidyl peptidase-4 (DPP-4) inhibitor
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
Treatment of type 2 diabetes
Target
DPP4 (CD26) [HSA:1803] [KO:K01278]
  Pathway
hsa04974  Protein digestion and absorption
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D10179  Trelagliptin succinate (JAN/USAN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01601  DPP-4 inhibitor
    DG01284  Trelagliptin
     D10179  Trelagliptin succinate
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG01284  Trelagliptin
    D10179  Trelagliptin succinate
Drug classes [BR:br08332]
 Antidiabetic agent
  DG01601  DPP-4 inhibitor
   D10179  Trelagliptin succinate
  DG02044  Hypoglycemic agent
   D10179  Trelagliptin succinate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-peptidases
    DPP4 (CD26)
     D10179  Trelagliptin succinate (JAN/USAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10179
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10179
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10179
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01601  DPP-4 inhibitor
    DG01284  Trelagliptin
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG01284  Trelagliptin
Other DBs
CAS: 1029877-94-8
PubChem: 135626897
LigandBox: D10179
LinkDB
KCF data

ATOM        34
            1   C8x C    26.1100  -23.5200
            2   C8y C    26.1100  -24.9200
            3   N4y N    24.9200  -25.6200
            4   C8y C    23.6600  -24.9200
            5   N4y N    23.6600  -23.5200
            6   C8y C    24.9200  -22.8200
            7   C1b C    22.4000  -22.8200
            8   C8y C    21.2100  -23.5200
            9   C8x C    21.2100  -24.9200
            10  C8y C    19.9500  -25.6200
            11  C8x C    18.7600  -24.9200
            12  C8x C    18.7600  -23.5200
            13  C8y C    19.9500  -22.8200
            14  C3b C    19.9500  -21.4200
            15  X   F    19.9500  -27.0200
            16  C1a C    24.9200  -27.0200
            17  O5x O    27.3000  -25.6200
            18  O5x O    22.4000  -25.6200
            19  N1y N    24.9200  -21.4200
            20  C1x C    23.7300  -20.7200
            21  C1y C    23.7300  -19.3200
            22  C1x C    24.9200  -18.6200
            23  C1x C    26.1100  -19.3200
            24  C1x C    26.1100  -20.7200
            25  N3a N    19.9500  -20.0200
            26  N1a N    22.4700  -18.6200
            27  O6a O    28.4200  -21.9800
            28  C6a C    29.6324  -22.6800
            29  C1b C    30.8279  -21.9896
            30  C1b C    32.0153  -22.6751
            31  C6a C    33.2065  -21.9871
            32  O6a O    34.3960  -22.6738
            33  O6a O    33.2065  -20.5803
            34  O6a O    29.6325  -24.0798
BOND        35
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   13  14 1
            16   10  15 1
            17    3  16 1
            18    2  17 2
            19    4  18 2
            20    6  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   19  24 1
            27   14  25 3
            28   21  26 1 #Down
            29   27  28 1
            30   28  29 1
            31   29  30 1
            32   30  31 1
            33   31  32 1
            34   31  33 2
            35   28  34 2

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