KEGG   DRUG: Luseogliflozin hydrateHelp
Entry
D10195                      Drug                                   

Name
Luseogliflozin hydrate (JAN);
Lusefi (TN)
Formula
C23H30O6S. xH2O
Structure
Mol fileKCF fileDB search
Class
Antidiabetic agent
 DG01794  SGLT2 inhibitor
 DG02044  Hypoglycemics
  DG01794  SGLT2 inhibitor
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
 DG02978  CYP4A11 substrate
 DG02980  CYP4F2 substrate
 DG02979  CYP4F3 substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 3969
Product: D10195<JP>
Efficacy
Antidiabetic, SGLT-2 inhibitor
Comment
Phlorizin derivative
Target
SLC5A2 (SGLT2) [HSA:6524] [KO:K14382]
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP4A11 [HSA:1579], CYP4F2 [HSA:8529], CYP4F3 [HSA:4051], UGT1A1 [HSA:54658]
Interaction
Drug interaction
Structure map
map07051  Antidiabetics
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D10195  Luseogliflozin hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC5
    SLC5A2 (SGLT2)
     D10195  Luseogliflozin hydrate (JAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10195
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10195
BRITE hierarchy
Other DBs
PubChem: 135626913
ChEMBL: CHEMBL3781004
LigandBox: D10195
LinkDB All DBs
KCF data Show

ATOM        31
            1   S2x S    14.1400  -14.7700
            2   C1y C    14.1400  -16.1700
            3   C1y C    12.9500  -16.8700
            4   C1y C    11.6900  -16.1700
            5   C1y C    11.6900  -14.7700
            6   C1y C    12.9500  -14.0700
            7   C1b C    12.9500  -12.6700
            8   O1a O    10.5000  -14.0700
            9   O1a O    12.9500  -18.2700
            10  O1a O    10.5000  -16.8700
            11  C8y C    15.3300  -16.8700
            12  C8x C    16.5200  -16.1700
            13  C8y C    17.7800  -16.8700
            14  C8y C    17.7800  -18.2700
            15  C8x C    16.5900  -18.9700
            16  C8y C    15.3300  -18.2700
            17  O2a O    14.1400  -18.9700
            18  C1a C    14.1400  -20.3700
            19  C1b C    18.9700  -16.1700
            20  C8y C    20.1600  -16.8700
            21  C8x C    22.6100  -16.8700
            22  C8y C    22.6100  -18.2700
            23  C8x C    21.4200  -18.9700
            24  C8x C    20.1600  -18.2700
            25  C8x C    21.3500  -16.1700
            26  O2a O    23.8000  -18.9700
            27  C1b C    24.9900  -18.2700
            28  C1a C    26.1800  -18.9700
            29  O1a O    14.1624  -11.9700
            30  C1a C    18.9953  -18.9651
            31  O0  O    25.4800  -13.0200
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     6   7 1 #Up
            8     5   8 1 #Down
            9     3   9 1 #Down
            10    4  10 1 #Up
            11    2  11 1 #Up
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   11  16 2
            18   16  17 1
            19   17  18 1
            20   13  19 1
            21   19  20 1
            22   21  22 1
            23   22  23 2
            24   23  24 1
            25   20  24 2
            26   20  25 1
            27   25  21 2
            28   22  26 1
            29   26  27 1
            30   27  28 1
            31    7  29 1
            32   14  30 1
BRACKET     1    23.4500  -13.8600   23.4500  -11.9700
            1    26.0400  -11.9700   26.0400  -13.8600
            1  x
 ORIGINAL  1   31
 REPEAT    1

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