KEGG   DRUG: Metoprolol and hydrochlorothiazide
Entry
D10273            Mixture   Drug                                   
Name
Metoprolol and hydrochlorothiazide;
Dutoprol (TN);
Lopressor hct (TN)
Product
  Generic
METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE (Ajanta Pharma USA), METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE (Alembic Pharmaceuticals Limited), METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE (Alembic Pharmaceuticals), METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE (Mylan Pharmaceuticals), METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE (Sun Pharmaceutical Industries)
Component
(Metoprolol tartrate [DR:D00601] | Metoprolol succinate [DR:D00635]), Hydrochlorothiazide [DR:D00340]
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: C07BB02
Product: D10273<US>
Efficacy
Antihypertensive
  Disease
Hypertension [DS:H01633]
Comment
Metoprolol is primarily metabolized by CYP2D6.
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07B BETA BLOCKING AGENTS AND THIAZIDES
    C07BB Beta blocking agents, selective, and thiazides
     C07BB02 Metoprolol and thiazides
      D10273  Metoprolol and hydrochlorothiazide <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Cardiovascular Agents, Combinations
   Hydrochlorothiazide/ Metoprolol Succinate
    D10273  Metoprolol and hydrochlorothiazide
   Hydrochlorothiazide/ Metoprolol Tartrate
    D10273  Metoprolol and hydrochlorothiazide
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D10273  Metoprolol and hydrochlorothiazide
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10273
Other DBs
PubChem: 163312304
LinkDB

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