KEGG   DISEASE: High blood pressure
H01633                      Disease                                
High blood pressure;
High blood pressure (hypertension) is the most frequent classic cardiovascular risk factor and accounts for a large proportion of cardiovascular mortality, the main cause of death worldwide. Hypertension is generally classified as primary (essential) or secondary. Essential hypertension (EH) is the most common diagnosis in this disease, suggesting that a monocausal etiology has not been identified. However, a number of risk factors associated with EH have also been identified such as age, sex, demographic, environmental, genetic, and vascular factors. Secondary hypertension generally has an earlier age at onset, no family history, and a clear cause such as a renal or endocrine disorder, or an iatrogenic trigger, such as use of oral contraceptives. Blood pressure is a heritable trait; an estimated 30% of variance in blood pressure relates to genetic factors. Understanding of the genetic architecture of traits has progressed in rare mendelian hypertensive phenotypes, such as Gordon's syndrome.
Cardiovascular disease
Human diseases [BR:br08402]
 Cardiovascular diseases
  Hypertensive diseases
   H01633  High blood pressure
Human diseases in ICD-11 classification [BR:br08403]
 11 Diseases of the circulatory system
  Hypertensive diseases
   BA00  Essential hypertension
    H01633  High blood pressure
hsa04925  Aldosterone synthesis and secretion
hsa04960  Aldosterone-regulated sodium reabsorption
CYP11B2 [HSA:1585] [KO:K07433]
CYP11B1 [HSA:1584] [KO:K00497]
HSD11B2 [HSA:3291] [KO:K00071]
NR3C2 [HSA:4306] [KO:K08555]
SCNN1B [HSA:6338] [KO:K04825]
SCNN1G [HSA:6340] [KO:K04827]
Methyldopa [DR:D00405]
Clonidine hydrochloride [DR:D00604]
Guanfacine hydrochloride [DR:D00606]
Mecamylamine hydrochloride [DR:D00611]
Prazosin hydrochloride [DR:D00609]
Doxazosin mesylate [DR:D00608]
Hydralazine hydrochloride [DR:D01302]
Minoxidil [DR:D00418]
Methyldopa and hydrochlorothiazide [DR:D10267]
Clonidine and chlorthalidone [DR:D10591]
Hydrochlorothiazide [DR:D00340]
Chlorothiazide [DR:D00519]
Methyclothiazide [DR:D00656]
Chlorthalidone [DR:D00272]
Indapamide [DR:D00345]
Furosemide [DR:D00331]
Torsemide [DR:D00382]
Spironolactone [DR:D00443]
Eplerenone [DR:D01115]
Hydrochlorothiazide and triamterene [DR:D10269]
Spironolactone and hydrochlorothiazide [DR:D10270]
Amiloride hydrochloride and hydrochlorothiazide [DR:D10271]
Phenoxybenzamine hydrochloride [DR:D00507]
Diltiazem hydrochloride [DR:D00616]
Pindolol [DR:D00513]
Propranolol hydrochloride [DR:D00483]
Nadolol [DR:D00432]
Metoprolol tartrate [DR:D00601]
Metoprolol succinate [DR:D00635]
Atenolol [DR:D00235]
Acebutolol hydrochloride [DR:D00597]
Betaxolol hydrochloride [DR:D00598]
Bisoprolol fumarate [DR:D00634]
Esmolol hydrochloride [DR:D00644]
Nebivolol hydrochloride [DR:D06622]
Labetalol hydrochloride [DR:D00600]
Carvedilol [DR:D00255]
Carvedilol phosphate [DR:D03415]
Propranolol hydrochloride and hydrochlorothiazide [DR:D10274]
Nadolol and bendroflumethiazide [DR:D10272]
Metoprolol and hydrochlorothiazide [DR:D10273]
Bisoprolol fumarate and hydrochlorothiazide [DR:D10275]
Atenolol and chlorthalidone [DR:D10592]
Amlodipine besylate [DR:D00615]
Amlodipine benzoate [DR:D11881]
Felodipine [DR:D00319]
Isradipine [DR:D00349]
Nicardipine hydrochloride [DR:D00617]
Nifedipine [DR:D00437]
Nisoldipine [DR:D00618]
Clevidipine [DR:D08892]
Levamlodipine maleate [DR:D11723]
Amlodipine and celecoxib [DR:D11705]
Verapamil hydrochloride [DR:D00619]
Captopril [DR:D00251]
Enalapril maleate [DR:D00621]
Lisinopril [DR:D00362]
Perindopril erbumine [DR:D00624]
Ramipril [DR:D00421]
Quinapril hydrochloride [DR:D00459]
Benazepril hydrochloride [DR:D00620]
Fosinopril sodium [DR:D00622]
Trandolapril [DR:D00383]
Moexipril hydrochloride [DR:D00623]
Captopril and hydrochlorothiazide [DR:D10276]
Enalapril maleate and hydrochlorothiazide [DR:D10277]
Hydrochlorothiazide and lisinopril [DR:D10268]
Quinapril hydrochloride and hydrochlorothiazide [DR:D10278]
Benazepril hydrochloride and hydrochlorothiazide [DR:D10279]
Fosinopril and hydrochlorothiazide [DR:D10280]
Moexipril hydrochloride and hydrochlorothiazide [DR:D10281]
Perindopril and amlodipine [DR:D11581]
Trandolapril and verapamil hydrochloride [DR:D10282]
Losartan potassium [DR:D00357]
Eprosartan mesylate [DR:D02082]
Valsartan [DR:D00400]
Irbesartan [DR:D00523]
Candesartan cilexetil [DR:D00626]
Telmisartan [DR:D00627]
Olmesartan medoxomil [DR:D01204]
Azilsartan medoxomil [DR:D08067]
Azilsartan kamedoxomil [DR:D08865]
Losartan potassium and hydrochlorothiazide [DR:D07895]
Eprosartan mesylate and hydrochlorothiazide [DR:D10283]
Valsartan and hydrochlorothiazide [DR:D09197]
Irbesartan and hydrochlorothiazide [DR:D10249]
Candesartan cilexetil and hydrochlorothiazide [DR:D09196]
Telmisartan and hydrochlorothiazide [DR:D09219]
Olmesartan medoxomil and hydrochlorothiazide [DR:D10284]
Azilsartan medoxomil and chlorthalidone [DR:D10589]
Valsartan and amlodipine besilate [DR:D09745]
Amlodipine besylate and olmesartan medoxomil [DR:D10285]
Telmisartan and amlodipine besilate [DR:D09743]
Amlodipine, valsartan and hydrochlorothiazide [DR:D10286]
Olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide [DR:D10288]
Nebivolol and valsartan [DR:D11388]
Aliskiren fumarate [DR:D06412]
Aliskiren hemifumarate and hydrochlorothiazide [DR:D10289]
Amlodipine besilate and atorvastatin calcium [DR:D08488]
Terazosin hydrochloride anhydrous [DR:D11585]
Enalaprilat [DR:D03769]
Methyldopate hydrochloride [DR:D04997]
Amlodipine and benazepril [DR:D11069]
Other DBs
ICD-11: BA00
ICD-10: I10
MeSH: D006973
Foex P, Sear JW.
Hypertension: pathophysiology and treatment.
Continuing Education in Anaesthesia, Critical Care & Pain 4:71-75 (2004)
Poulter NR, Prabhakaran D, Caulfield M
Lancet 386:801-12 (2015)
Singh M, Singh AK, Pandey P, Chandra S, Singh KA, Gambhir IS
Molecular genetics of essential hypertension.
Clin Exp Hypertens 38:268-77 (2016)
Ehret GB, Caulfield MJ
Genes for blood pressure: an opportunity to understand hypertension.
Eur Heart J 34:951-61 (2013)

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