KEGG   DRUG: VorsetuzumabHelp
Entry
D10342                      Drug                                   

Name
Vorsetuzumab (USAN/INN)
Formula
C6476H10006N1726O2028S50
Exact mass
146001.8934
Mol weight
146092.3382
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT NYGMNWVRQA PGQGLKWMGW INTYTGEPTY
ADAFKGRVTM TRDTSISTAY MELSRLRSDD TAVYYCARDY GDYGMDYWGQ GTTVTVSSAS
TKGPSVFPLA PSSKSTSGGT AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVP SSSLGTQTYI CNVNHKPSNT KVDKKVEPKS CDKTHTCPPC PAPELLGGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ
GNVFSCSVMH EALHNHYTQK SLSLSPGK
(Light chain)
DIVMTQSPDS LAVSLGERAT INCRASKSVS TSGYSFMHWY QQKPGQPPKL LIYLASNLES
GVPDRFSGSG SGTDFTLTIS SLQAEDVAVY YCQHSREVPW TFGQGTKVEI KRTVAAPSVF
IFPPSDEQLK SGTASVVCL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(dimer; disulfide bridges: H22-H96, H145-H201, H221-L218, H227-H'227, H230-H'230, H262-H322, H368-H426, H'22-H'96, H'145-H'201, H'221-L'218, H'262-H'322,H'368-H'426, L23-L92, H138-L198, L'23-L'92, L'138-L'198)
  Type
Peptide
Efficacy
Antineoplastic, Anti-CD70 antibody
Comment
Monoclonal antibody
Target
TNFSF7 (CD70) [HSA:970] [KO:K05470]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNFSF7 (CD70)
     D10342  Vorsetuzumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 1165740-62-4
PubChem: 172232436
LinkDB All DBs

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