KEGG   DRUG: FilorexantHelp
Entry
D10345                      Drug                                   

Name
Filorexant (USAN)
Formula
C24H25FN4O2
Exact mass
420.1962
Mol weight
420.4793
Structure
Mol fileKCF fileDB search
Efficacy
Hypnotic, Olexin receptor antagonist
Comment
Treatment of insomnia
Target
HCRTR [HSA:3061 3062] [KO:K04238 K04239]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Orexin
    HCRTR
     D10345  Filorexant (USAN)
BRITE hierarchy
Other DBs
CAS: 1088991-73-4
PubChem: 172232439
ChEMBL: CHEMBL2107822 CHEMBL3928138
LinkDB All DBs
KCF data Show

ATOM        31
            1   C8y C    12.5926  -14.7592
            2   C8x C    12.5926  -16.1584
            3   C8x C    13.8043  -16.8580
            4   C8y C    15.0160  -16.1584
            5   N5x N    15.0160  -14.7592
            6   C8x C    13.8043  -14.0596
            7   O2a O    16.2464  -16.8690
            8   C1b C    17.4509  -16.1737
            9   C1y C    18.6325  -16.8561
            10  C1x C    18.6324  -18.2569
            11  C1x C    19.8441  -18.9566
            12  C1y C    21.0559  -18.2571
            13  N1y N    21.0560  -16.8563
            14  C1x C    19.8443  -16.1566
            15  C5a C    22.2682  -16.1566
            16  C8y C    23.4645  -16.8476
            17  C8x C    23.4644  -18.2568
            18  C8y C    24.6761  -18.9565
            19  C8x C    25.8879  -18.2569
            20  C8x C    25.8880  -16.8477
            21  C8y C    24.6763  -16.1480
            22  C8y C    24.6765  -14.7593
            23  N5x N    25.9025  -14.0516
            24  C8x C    25.9026  -12.6525
            25  C8x C    24.6909  -11.9528
            26  C8x C    23.4649  -12.6605
            27  N5x N    23.4648  -14.0596
            28  X   F    11.3809  -14.0596
            29  O5a O    22.2683  -14.7594
            30  C1a C    24.6761  -20.3558
            31  C1a C    22.2687  -18.9576
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     9   8 1 #Up
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15    9  14 1
            16   13  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   16  21 1
            24   21  22 1
            25   22  23 2
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   26  27 2
            30   22  27 1
            31    1  28 1
            32   15  29 2
            33   18  30 1
            34   12  31 1 #Down

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