KEGG   DRUG: DemcizumabHelp
Entry
D10353                      Drug                                   

Name
Demcizumab (USAN/INN)
Formula
C6444H10004N1700O2028S52
Exact mass
145315.742
Mol weight
145405.9358
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKI SCKASGYSFT AYYIHWVKQA PGQGLEWIGY ISSYNGATNY
NQKFKGRVTF TTDTSTSTAY MELRSLRSDD TAVYYCARDY DYDVGMDYWG QGTLVTVSSA
STKGPSVFPL APCSRSTSES TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSNFGTQTY TCNVDHKPSN TKVDKTVERK CCVECPPCPA PPVAGPSVFL
FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTFRV
VSVLTVVHQD WLNGKEYKCK VSNKGLPAPI EKTISKTKGQ PREPQVYTLP PSREEMTKNQ
VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPMLDSDG SFFLYSKLTV DKSRWQQGNV
FSCSVMHEAL HNHYTQKSLS LSPG
(Light chain)
DIVMTQSPDS LAVSLGERAT ISCRASESVD NYGISFMKWF QQKPGQPPKL LIYAASNQGS
GVPDRFSGSG SGTDFTLTIS SLQAEDVAVY YCQQSKEVPW TFGGGTKVEI KRTVAAPSVF
IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(dimer; disulfide bridges: H22-H96, H133-L218, H146-H202, H221-H'221, H222-H'222, H225-H'225, H228-H'228, H259-H319, H365-H423, H'22-H'96, H'133-L'218, H'146-H'202, H'259-H'319, H'365-H'423, L23-L92, L138-L198, L'23-L'92, L'138-L'198)
  Type
Peptide
Efficacy
Antineoplastic, Anti-delta-like 4 (DLL4) antibody
Comment
Monoclonal antibody
Target
DLL4 [HSA:54567] [KO:K06051]
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Signaling molecules
   Notch signaling
    DLL4
     D10353  Demcizumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 1243262-17-0
PubChem: 172232446
LinkDB All DBs

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