Homo sapiens (human): 54567
Help
Entry
54567 CDS
T01001
Symbol
DLL4, AOS6, delta4, hdelta2
Name
(RefSeq) delta like canonical Notch ligand 4
KO
K06051
delta
Organism
hsa
Homo sapiens (human)
Pathway
hsa01522
Endocrine resistance
hsa04330
Notch signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa05200
Pathways in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05224
Breast cancer
Network
nt06166
Human papillomavirus (HPV)
nt06216
NOTCH signaling (cancer)
nt06227
Nuclear receptor signaling (cancer)
nt06270
Breast cancer
nt06465
Prion disease
nt06511
NOTCH signaling
Element
N00086
Notch signaling pathway
N00087
NOTCH-overexpression to Notch signaling pathway
N01364
E2 to nuclear-initiated estrogen signaling pathway
N01479
Notch ligand ubiquitylation
Disease
H01413
Adams-Oliver syndrome
Drug target
Demcizumab:
D10353
Dilpacimab:
D11642
Enoticumab:
D10460
Navicixizumab:
D11126
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
54567 (DLL4)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
54567 (DLL4)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
54567 (DLL4)
05207 Chemical carcinogenesis - receptor activation
54567 (DLL4)
09162 Cancer: specific types
05224 Breast cancer
54567 (DLL4)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
54567 (DLL4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MNNL
EGF
EGF_TEN
hEGF
EGF_DL_JAG
DSL
JAG1-like_EGF2
EGF_2
EGF_Teneurin
EGF_3
cEGF
DUF4381
EGF_laminin
Motif
Other DBs
NCBI-GeneID:
54567
NCBI-ProteinID:
NP_061947
OMIM:
605185
HGNC:
2910
Ensembl:
ENSG00000128917
UniProt:
Q9NR61
Structure
PDB
PDBj
LinkDB
All DBs
Position
15:40929340..40939073
Genome browser
AA seq
685 aa
AA seq
DB search
MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRV
CLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIE
AWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYY
GDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECL
CRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC
SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCE
HSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR
GPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS
IDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAV
LLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGL
DKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICS
PRDSMYQSVCLISEERNECVIATEV
NT seq
2058 nt
NT seq
+upstream
nt +downstream
nt
atggcggcagcgtcccggagcgcctctggctgggcgctactgctgctggtggcactttgg
cagcagcgcgcggccggctccggcgtcttccagctgcagctgcaggagttcatcaacgag
cgcggcgtactggccagtgggcggccttgcgagcccggctgccggactttcttccgcgtc
tgccttaagcacttccaggcggtcgtctcgcccggaccctgcaccttcgggaccgtctcc
acgccggtattgggcaccaactccttcgctgtccgggacgacagtagcggcggggggcgc
aaccctctccaactgcccttcaatttcacctggccgggtaccttctcgctcatcatcgaa
gcttggcacgcgccaggagacgacctgcggccagaggccttgccaccagatgcactcatc
agcaagatcgccatccagggctccctagctgtgggtcagaactggttattggatgagcaa
accagcaccctcacaaggctgcgctactcttaccgggtcatctgcagtgacaactactat
ggagacaactgctcccgcctgtgcaagaagcgcaatgaccacttcggccactatgtgtgc
cagccagatggcaacttgtcctgcctgcccggttggactggggaatattgccaacagcct
atctgtctttcgggctgtcatgaacagaatggctactgcagcaagccagcagagtgcctc
tgccgcccaggctggcagggccggctgtgtaacgaatgcatcccccacaatggctgtcgc
cacggcacctgcagcactccctggcaatgtacttgtgatgagggctggggaggcctgttt
tgtgaccaagatctcaactactgcacccaccactccccatgcaagaatggggcaacgtgc
tccaacagtgggcagcgaagctacacctgcacctgtcgcccaggctacactggtgtggac
tgtgagctggagctcagcgagtgtgacagcaacccctgtcgcaatggaggcagctgtaag
gaccaggaggatggctaccactgcctgtgtcctccgggctactatggcctgcattgtgaa
cacagcaccttgagctgcgccgactccccctgcttcaatgggggctcctgccgggagcgc
aaccagggggccaactatgcttgtgaatgtccccccaacttcaccggctccaactgcgag
aagaaagtggacaggtgcaccagcaacccctgtgccaacgggggacagtgcctgaaccga
ggtccaagccgcatgtgccgctgccgtcctggattcacgggcacctactgtgaactccac
gtcagcgactgtgcccgtaacccttgcgcccacggtggcacttgccatgacctggagaat
gggctcatgtgcacctgccctgccggcttctctggccgacgctgtgaggtgcggacatcc
atcgatgcctgtgcctcgagtccctgcttcaacagggccacctgctacaccgacctctcc
acagacacctttgtgtgcaactgcccttatggctttgtgggcagccgctgcgagttcccc
gtgggcttgccgcccagcttcccctgggtggccgtctcgctgggtgtggggctggcagtg
ctgctggtactgctgggcatggtggcagtggctgtgcggcagctgcggcttcgacggccg
gacgacggcagcagggaagccatgaacaacttgtcggacttccagaaggacaacctgatt
cctgccgcccagcttaaaaacacaaaccagaagaaggagctggaagtggactgtggcctg
gacaagtccaactgtggcaaacagcaaaaccacacattggactataatctggccccaggg
cccctggggcgggggaccatgccaggaaagtttccccacagtgacaagagcttaggagag
aaggcgccactgcggttacacagtgaaaagccagagtgtcggatatcagcgatatgctcc
cccagggactccatgtaccagtctgtgtgtttgatatcagaggagaggaatgaatgtgtc
attgccacggaggtataa
DBGET
integrated database retrieval system
