KEGG   DRUG: InclacumabHelp
Entry
D10356                      Drug                                   

Name
Inclacumab (USAN/INN)
Formula
C6452H9930N1730O2024S42
Exact mass
145373.5548
Mol weight
145462.9872
Sequence
(Heavy chain)
EVQLVESGGG LVRPGGSLRL SCAASGFTFS NYDMHWVRQA TGKGLEWVSA ITAAGDIYYP
GSVKGRFTIS RENAKNSLYL QMNSLRAGDT AVYYCARGRY SGSGSYYNDW FDPWGQGTLV
TVSSASTKGP SVFPLAPCSR STSESTAALG CLVKDYFPEP VTVSWNSGAL TSGVHTFPAV
LQSSGLYSLS SVVTVPSSSL GTKTYTCNVD HKPSNTKVDK RVESKYGPPC PPCPAPEFEG
GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SQEDPEVQFN WYVDGVEVHN AKTKPREEQF
NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK GLPSSIEKTI SKAKGQPREP QVYTLPPSQE
EMTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSRLTVDKSR
WQEGNVFSCS VMHEALHNHY TQKSLSLSLG K
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCRASQSVS SYLAWYQQKP GQAPRLLIYD ASNRATGIPA
RFSGSGSGTD FTLTISSLEP EDFAVYYCQQ RSNWPLTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(dimer; disulfide bridges: H22-H95, H138-L214, H151-H207, H230-H'230, H233-H'233, H265-H325, H371-H429, H'22-H'95, H'138-L'214, H'151-H'207, H'265-H'325, H'371-H'429, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Anti-inflammatory, Anti-ischemic, Anti-P-selectin antibody
Comment
Monoclonal antibody
Treatment of cardiovascular disease
Target
SELP (CD62P) [HSA:6403] [KO:K06496]
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Cell adhesion molecules: other families
   Selectins
    SELP (CD62P)
     D10356  Inclacumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 1256258-86-2
PubChem: 172232449
LinkDB All DBs

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