KEGG   DRUG: Sebelipase alfaHelp
Entry
D10377                      Drug                                   

Name
Sebelipase alfa (USAN);
Sebelipase alfa (genetical recombination) (JAN);
Kanuma (TN)
Product
Formula
C1968H2945N507O551S15
Exact mass
42976.3823
Mol weight
43003.4822
Sequence
SGGKLTAVDP ETNMNVSEII SYWGFPSEEY LVETEDGYIL CLNRIPHGRK NHSDKGPKPV
VFLQHGLLAD SSNWVTNLAN SSLGFILADA GFDVWMGNSR GNTWSRKHKT LSVSQDEFWA
FSYDEMAKYD LPASINFILN KTGQEQVYYV GHSQGTTIGF IAFSQIPELA KRIKMFFALG
PVASVAFCTS PMAKLGRLPD HLIKDLFGDK EFLPQSAFLK WLGTHVCTHV ILKELCGNLC
FLLCGFNERN LNMSRVDVYT THSPAGTSVQ NMLHWSQAVK FQKFQAFDWG SSAKNYFHYN
QSYPPTYNVK DMLVPTAVWS GGHDWLADVY DVNILLTQIT NLVFHESIPE WEHLDFIWGL
DAPWRLYNKI INLMRKYQ
(glycosylation sites (N) :Asn-15, Asn-80, Asn-140, Asn-252,
Asn-300)
  Type
Peptide
Remark
Therapeutic category: 3959
ATC code: A16AB14
Product: D10377<JP/US>
Efficacy
Enzyme replenisher
  Disease
Lysosomal acid lipase deficiency [DS:H00148]
Comment
for lysosomal acid lipase (LAL) deficiency
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB14 Sebelipasealfa
      D10377  Sebelipase alfa (USAN) <JP/US>
USP drug classification [BR:br08302]
 Genetic or Enzyme Disorder: Replacement, Modifiers, Treatment
  Sebelipase Alfa
   D10377  Sebelipase alfa (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D10377  Sebelipase alfa (USAN); Sebelipase alfa (genetical recombination) (JAN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D10377
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10377
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10377
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10377
BRITE hierarchy
Other DBs
CAS: 1276027-63-4
PubChem: 172232470
LinkDB All DBs

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