Homo sapiens (human): 3988 Help Entry 3988              CDS       T01001                                  Symbol LIPA, CESD, LAL Name (RefSeq) lipase A, lysosomal acid type   KO K01052   lysosomal acid lipase/cholesteryl ester hydrolase [EC:3.1.1.13] Organism hsa  Homo sapiens (human) Pathway hsa00100   Steroid biosynthesis hsa04142   Lysosome hsa04148   Efferocytosis hsa04979   Cholesterol metabolism Network nt06535  Efferocytosis   Element N01780   Hydrolyzing AC-derived cholesterol esters in the lysosome Disease H00148   Lysosomal acid lipase deficiency Drug target Sebelipase alfa:  D10377<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00100 Steroid biosynthesis     3988 (LIPA)  09140 Cellular Processes   09141 Transport and catabolism    04142 Lysosome     3988 (LIPA)    04148 Efferocytosis     3988 (LIPA)  09150 Organismal Systems   09154 Digestive system    04979 Cholesterol metabolism     3988 (LIPA) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.1  Carboxylic-ester hydrolases     3.1.1.13  sterol esterase      3988 (LIPA) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Abhydrolase_1 Abhydro_lipase Hydrolase_4 Motif Other DBs NCBI-GeneID:  3988 NCBI-ProteinID:  NP_000226 OMIM:  613497 HGNC:  6617 Ensembl:  ENSG00000107798 UniProt:  P38571 Structure PDB LinkDB All DBs Position 10:complement(89213572..89251775) Genome browser AA seq 399 aa AA seqDB search MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYI LCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNS RGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIG FIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFL KWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAV KFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQI TNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ NT seq 1200 nt NT seq  +upstreamnt  +downstreamnt atgaaaatgcggttcttggggttggtggtctgtttggttctctggaccctgcattctgag gggtctggagggaaactgacagctgtggatcctgaaacaaacatgaatgtgagtgaaatt atctcttactggggattccctagtgaggaatacctagttgagacagaagatggatatatt ctgtgccttaaccgaattcctcatgggaggaagaaccattctgacaaaggtcccaaacca gttgtcttcctgcaacatggcttgctggcagattctagtaactgggtcacaaaccttgcc aacagcagcctgggcttcattcttgctgatgctggttttgacgtgtggatgggcaacagc agaggaaatacctggtctcggaaacataagacactctcagtttctcaggatgaattctgg gctttcagttatgatgagatggcaaaatatgacctaccagcttccattaacttcattctg aataaaactggccaagaacaagtgtattatgtgggtcattctcaaggcaccactataggt tttatagcattttcacagatccctgagctggctaaaaggattaaaatgttttttgccctg ggtcctgtggcttccgtcgccttctgtactagccctatggccaaattaggacgattacca gatcatctcattaaggacttatttggagacaaagaatttcttccccagagtgcgtttttg aagtggctgggtacccacgtttgcactcatgtcatactgaaggagctctgtggaaatctc tgttttcttctgtgtggatttaatgagagaaatttaaatatgtctagagtggatgtatat acaacacattctcctgctggaacttctgtgcaaaacatgttacactggagccaggctgtt aaattccaaaagtttcaagcctttgactggggaagcagtgccaagaattattttcattac aaccagagttatcctcccacatacaatgtgaaggacatgcttgtgccgactgcagtctgg agcgggggtcacgactggcttgcagatgtctacgacgtcaatatcttactgactcagatc accaacttggtgttccatgagagcattccggaatgggagcatcttgacttcatttggggc ctggatgccccttggaggctttataataaaattattaatctaatgaggaaatatcagtga

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