KEGG   DRUG: VibegronHelp
Entry
D10433                      Drug                                   

Name
Vibegron (JAN/USAN);
Beova (TN)
Formula
C26H28N4O3
Exact mass
444.2161
Mol weight
444.5255
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
Remark
Therapeutic category: 2590
Product: D10433<JP>
Efficacy
Antidysuria, beta3-Adrenergic receptor agonist
Comment
Treatment of overactive bladder
Target
ADRB3 [HSA:155] [KO:K04143]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: ABCB1 [HSA:5243]
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D10433  Vibegron (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB3
     D10433  Vibegron (JAN/USAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10433
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10433
BRITE hierarchy
Other DBs
CAS: 1190389-15-1
PubChem: 172232526
ChEBI: 142418
ChEMBL: CHEMBL2107826
LinkDB All DBs
KCF data Show

ATOM        33
            1   C5a C    25.5500  -16.4500
            2   N1b N    24.3600  -15.7500
            3   C8y C    23.1700  -16.4500
            4   C8x C    21.9800  -15.7500
            5   C8x C    20.7200  -16.4500
            6   C8y C    20.7200  -17.8500
            7   C8x C    21.9100  -18.5500
            8   C8x C    23.1700  -17.8500
            9   C1b C    19.5300  -18.5500
            10  C1y C    18.3400  -17.8500
            11  C1x C    17.9200  -16.5200
            12  C1x C    16.5200  -16.5200
            13  C1y C    16.0300  -17.8500
            14  N1x N    17.1500  -18.6900
            15  C1c C    14.8400  -18.5500
            16  C8y C    13.6500  -17.8500
            17  C8x C    13.6500  -16.4500
            18  C8x C    12.3900  -15.7500
            19  C8x C    11.2000  -16.4500
            20  C8x C    11.2000  -17.8500
            21  C8x C    12.3900  -18.5500
            22  O1a O    14.8400  -19.9500
            23  C1y C    26.7400  -15.7500
            24  O5a O    25.5500  -17.8500
            25  C8x C    30.8700  -15.0500
            26  C8x C    30.5200  -16.3800
            27  C8y C    29.1200  -16.7300
            28  N4y N    28.1400  -15.7500
            29  C8y C    28.5600  -14.3500
            30  N5x N    29.9600  -14.0700
            31  O5x O    28.7700  -18.0600
            32  C1x C    26.3200  -14.4900
            33  C1x C    27.3700  -13.5800
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     6   7 1
            7     7   8 2
            8     3   8 1
            9     6   9 1
            10   10   9 1 #Up
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1 #Up
            15   10  14 1
            16   15  16 1
            17   15  13 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   16  21 1
            24   15  22 1 #Down
            25   23   1 1 #Down
            26    1  24 2
            27   25  26 2
            28   26  27 1
            29   27  28 1
            30   28  29 1
            31   29  30 2
            32   25  30 1
            33   27  31 2
            34   28  23 1
            35   32  33 1
            36   29  33 1
            37   32  23 1

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