KEGG   DRUG: EnoticumabHelp
Entry
D10460                      Drug                                   

Name
Enoticumab (USAN/INN)
Sequence
(Heavy chain)
QVQLVESGGG VVQPGRSLRL SCAASGFTFS SYGMHWVRQA PGKGLEWVSF LWYDGTNKNY
VESVKGRFTI SRDNSKNMLY LEMNSLRAED TAVYYCARDH DFRSGYEGWF DPWGQGTLVT
VSSASTKGPS VFPLAPSSKS TSGGTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL
QSSGLYSLSS VVTVPSSSLG TQTYICNVNH KPSNTKVDKK VEPKSCDKTH TCPPCPAPEL
LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE
QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS
RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK
SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PG
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCRASQSVS SYLAWYQQKP GQAPRLLIYD ASNRATGIPA
RFSGSGSGTD FTLTISSLEP EDFAVYYCQH RSNWPPTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(dimer; disulfide bridge: H22-H96, H150-H206, H226-L214, H232-H'232, H235-H'235, H267-H327, H373-H431, H'22-H'96, H'150-H'206, H'226-L'214, H'267-H'327, H'267-H'327, H'373-H'431, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antineoplastic, Immunomodulator, Delta-like 4 (DLL4) antibody
Comment
Monoclonal antibody
Target
DLL4 [HSA:54567] [KO:K06051]
  Pathway
hsa04330  Notch signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Signaling molecules
   Notch signaling
    DLL4
     D10460  Enoticumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 1192578-27-0
PubChem: 172232553
LinkDB All DBs

» Japanese version   » Back

DBGET integrated database retrieval system