KEGG   DRUG: Ripasudil hydrochloride hydrateHelp
Entry
D10463                      Drug                                   

Name
Ripasudil hydrochloride hydrate (JAN);
Glanatec (TN)
Formula
C15H18FN3O2S. HCl. 2H2O
Exact mass
395.1082
Mol weight
395.8772
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Therapeutic category: 1319
Product: D10463<JP>
Efficacy
Antiglaucoma, Rho-associated kinase inhibitor
Target
ROCK [HSA:6093 9475] [KO:K04514 K17388]
  Pathway
hsa04270  Vascular smooth muscle contraction
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D10463  Ripasudil hydrochloride hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   DMPK family
    ROCK
     D10463  Ripasudil hydrochloride hydrate (JAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10463
BRITE hierarchy
Other DBs
PubChem: 172232556
LinkDB All DBs
KCF data Show

ATOM        25
            1   C1x C    18.9000  -15.4700
            2   C1x C    18.0600  -14.3500
            3   C1x C    18.3400  -12.9500
            4   N1x N    19.6700  -12.3900
            5   N1y N    20.3000  -15.4700
            6   C1x C    20.8600  -13.0200
            7   C1y C    21.2100  -14.3500
            8   S4a S    20.3000  -16.8700
            9   C8y C    20.3000  -18.2700
            10  O3c O    21.7000  -16.8700
            11  O3c O    18.9000  -16.8700
            12  C8x C    19.1100  -18.9700
            13  C8x C    19.1100  -20.3700
            14  C8x C    20.3000  -21.0700
            15  C8y C    21.4900  -20.3700
            16  C8y C    21.4900  -18.9700
            17  C8x C    22.7500  -21.0700
            18  N5x N    23.9400  -20.3700
            19  C8x C    23.9400  -18.9700
            20  C8y C    22.7500  -18.2700
            21  C1a C    22.5785  -14.6453
            22  X   F    22.7672  -16.8701
            23  X   Cl   26.2500  -16.5900
            24  O0  O    26.7400  -18.3400
            25  O0  O    26.7400  -19.6700
BOND        24
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     5   8 1
            9     8   9 1
            10    8  10 2
            11    8  11 2
            12    9  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17    9  16 1
            18   15  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   16  20 1
            23    7  21 1 #Down
            24   20  22 1

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