KEGG   ORTHOLOGY: K17388
Entry
K17388                      KO                                     
Symbol
ROCK2
Name
Rho-associated protein kinase 2 [EC:2.7.11.39]
Pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04071  Sphingolipid signaling pathway
map04270  Vascular smooth muscle contraction
map04310  Wnt signaling pathway
map04360  Axon guidance
map04510  Focal adhesion
map04520  Adherens junction
map04530  Tight junction
map04611  Platelet activation
map04670  Leukocyte transendothelial migration
map04810  Regulation of actin cytoskeleton
map04921  Oxytocin signaling pathway
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05163  Human cytomegalovirus infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04071 Sphingolipid signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04024 cAMP signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04022 cGMP-PKG signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17388  ROCK2; Rho-associated protein kinase 2
   04520 Adherens junction
    K17388  ROCK2; Rho-associated protein kinase 2
   04530 Tight junction
    K17388  ROCK2; Rho-associated protein kinase 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K17388  ROCK2; Rho-associated protein kinase 2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K17388  ROCK2; Rho-associated protein kinase 2
   04670 Leukocyte transendothelial migration
    K17388  ROCK2; Rho-associated protein kinase 2
   04062 Chemokine signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K17388  ROCK2; Rho-associated protein kinase 2
  09158 Development and regeneration
   04360 Axon guidance
    K17388  ROCK2; Rho-associated protein kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K17388  ROCK2; Rho-associated protein kinase 2
   05205 Proteoglycans in cancer
    K17388  ROCK2; Rho-associated protein kinase 2
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K17388  ROCK2; Rho-associated protein kinase 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K17388  ROCK2; Rho-associated protein kinase 2
   05132 Salmonella infection
    K17388  ROCK2; Rho-associated protein kinase 2
   05131 Shigellosis
    K17388  ROCK2; Rho-associated protein kinase 2
   05135 Yersinia infection
    K17388  ROCK2; Rho-associated protein kinase 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17388  ROCK2; Rho-associated protein kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K17388  ROCK2; Rho-associated protein kinase 2
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K17388  ROCK2; Rho-associated protein kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.39  ROCK-subfamily protein kinase
     K17388  ROCK2; Rho-associated protein kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   K17388  ROCK2; Rho-associated protein kinase 2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    K17388  ROCK2; Rho-associated protein kinase 2
Genes
HSA: 9475(ROCK2)
PTR: 470307(ROCK2)
PPS: 100969111(ROCK2)
GGO: 101134988(ROCK2)
PON: 100461801(ROCK2)
PPYG: 129029200(ROCK2)
NLE: 100585294(ROCK2)
HMH: 116480242(ROCK2)
SSYN: 129468352(ROCK2)
MCC: 708444(ROCK2)
MCF: 102133054(ROCK2)
MTHB: 126933801
MNI: 105486481(ROCK2)
CSAB: 103220805(ROCK2)
CATY: 105578625(ROCK2)
PANU: 101003099(ROCK2)
TGE: 112604719(ROCK2)
MLEU: 105528513(ROCK2)
RRO: 104675191(ROCK2)
RBB: 108516461(ROCK2)
TFN: 117062719(ROCK2)
PTEH: 111532006(ROCK2)
CANG: 105525318(ROCK2)
CJC: 100408337(ROCK2)
SBQ: 101039371(ROCK2)
CIMI: 108301473(ROCK2)
ANAN: 105707777(ROCK2)
CSYR: 103267985(ROCK2)
MMUR: 105880217(ROCK2)
LCAT: 123636599(ROCK2)
ERUF: 138400204(ROCK2)
PCOQ: 105814034(ROCK2)
OGA: 100953342(ROCK2)
MMU: 19878(Rock2)
MCAL: 110306686(Rock2)
MPAH: 110324181(Rock2)
RNO: 25537(Rock2)
MCOC: 116080601(Rock2)
ANU: 117716790(Rock2)
ASYL: 127687452(Rock2)
MUN: 110541556(Rock2)
CGE: 100767265(Rock2)
MAUA: 101838535(Rock2)
PROB: 127219989(Rock2)
PLEU: 114698838(Rock2)
PMAV: 102925977(Rock2)
MFOT: 126501334
AAMP: 119807701(Rock2)
CNL: 130887689(Rock2)
NGI: 103747607(Rock2)
HGL: 101724195(Rock2)
CPOC: 100713798(Rock2)
CCAN: 109684863(Rock2)
DORD: 105983611(Rock2)
DSP: 122108760(Rock2)
DMER: 138822479(Rock2)
PLOP: 125356729(Rock2)
NCAR: 124962770
MMMA: 107137496(Rock2)
ITI: 101972773(Rock2)
OCU: 100346837
OPI: 101533973(ROCK2)
OCZ: 121164685(ROCK2)
TUP: 102490242(ROCK2)
GVR: 103590666(ROCK2)
CFA: 482970(ROCK2)
CLUD: 112664826(ROCK2)
VVP: 112927709(ROCK2)
VLG: 121490634(ROCK2)
NPO: 129510900(ROCK2)
AML: 100466003(ROCK2)
UMR: 103660117(ROCK2)
UAH: 113269955(ROCK2)
UAR: 123778572(ROCK2)
ELK: 111154090
LLV: 125108362
MPUF: 101681879(ROCK2)
MNP: 132021141(ROCK2)
MLK: 131807367(ROCK2)
NVS: 122915310(ROCK2)
ORO: 101372971(ROCK2)
EJU: 114205781(ROCK2)
ZCA: 113937156(ROCK2)
MLX: 118007595(ROCK2)
MANO: 123850829(ROCK2)
NSU: 110587399(ROCK2)
LWW: 102747780
FCA: 101094501(ROCK2)
PYU: 121044101(ROCK2)
PCOO: 112864195(ROCK2)
PBG: 122497462(ROCK2)
PVIV: 125158293(ROCK2)
LRUF: 124504219
LGF: 123581580(ROCK2)
AJU: 106977263
PTG: 102949986(ROCK2)
PPAD: 109268495(ROCK2)
PUC: 125937677
PLEZ: 122216616(ROCK2)
HHV: 120231144(ROCK2)
CCRU: 144220645(ROCK2)
BTA: 282041(ROCK2)
BOM: 102267122(ROCK2)
BIU: 109566382(ROCK2)
BJV: 133257436(ROCK2)
BBUB: 102409368(ROCK2)
BKE: 129623455(ROCK2)
BBIS: 104997365(ROCK2)
CHX: 102181692(ROCK2)
OAS: 101103800(ROCK2)
OCAN: 138436673(ROCK2)
BTAX: 128055373(ROCK2)
CSUM: 138086497(ROCK2)
ODA: 120851858(ROCK2)
CCAD: 122442064(ROCK2)
MREE: 136163840(ROCK2)
OVR: 110130910(ROCK2)
MBEZ: 129539650(ROCK2)
SSC: 397445(ROCK2)
CFR: 102512572(ROCK2)
CBAI: 105076019(ROCK2)
CDK: 105091254(ROCK2)
VPC: 102524824(ROCK2)
BACU: 102999355(ROCK2)
BMUS: 118905800(ROCK2)
LVE: 103081507(ROCK2)
OOR: 101289250(ROCK2)
LALB: 132531154(ROCK2)
GMF: 115846108(ROCK2)
DDP: 132435116(ROCK2)
DLE: 111164467(ROCK2)
PCAD: 102994518(ROCK2)
PSIU: 116764174(ROCK2)
PPHC: 136133632(ROCK2)
NASI: 112394771(ROCK2)
ECB: 100072339(ROCK2)
EPZ: 103557393(ROCK2)
EAI: 106846040(ROCK2)
MYB: 102254781(ROCK2)
MYD: 102763604(ROCK2)
MMYO: 118669273(ROCK2)
MLF: 102431516(ROCK2)
MDT: 132213639(ROCK2)
MYUM: 139019695(ROCK2)
PKL: 118717047(ROCK2)
EFUS: 103305588(ROCK2)
MNA: 107542396(ROCK2)
DRO: 112297718(ROCK2)
SHON: 118988767(ROCK2)
AJM: 119053927(ROCK2)
PDIC: 114498743(ROCK2)
PHAS: 123822396(ROCK2)
MMF: 118630612(ROCK2)
PPAM: 129067577(ROCK2)
HAI: 109386644(ROCK2)
RFQ: 117033436(ROCK2)
PALE: 102897424(ROCK2)
PGIG: 120621957(ROCK2)
PVP: 105295461(ROCK2)
RAY: 107501194(ROCK2)
MJV: 108409101(ROCK2)
TOD: 119259551(ROCK2)
SARA: 101539253(ROCK2)
SFUM: 130031562(ROCK2)
SETR: 126024093(ROCK2)
LAV: 100658857(ROCK2)
TMU: 101345959
ETF: 101646611(ROCK2)
DNM: 101428161
MDO: 100032706(ROCK2)
GAS: 123233446(ROCK2)
SHR: 100916865(ROCK2)
AFZ: 127548167
PCW: 110207655(ROCK2)
TVP: 118842885(ROCK2)
PBRV: 138146817(ROCK2)
MLAO: 141502757(ROCK2)
OAA: 100073941(ROCK2)
TACU: 119932513(ROCK2)
GGA: 374182(ROCK2)
PCOC: 116240378(ROCK2)
MGP: 100538826(ROCK2)
CJO: 107312208(ROCK2)
TPAI: 128084251(ROCK2)
LMUT: 125690189(ROCK2)
NMEL: 110395385(ROCK2)
APLA: 101792620(ROCK2)
AACU: 137854764(ROCK2)
OJA: 118165309(ROCK2)
ACYG: 106030727(ROCK2)
CATA: 118255936(ROCK2)
AFUL: 116487357(ROCK2)
TGU: 100221127(ROCK2)
LSR: 110467944(ROCK2)
VMC: 128804469(ROCK2)
VCHA: 128786517(ROCK2)
AIB: 137470291(ROCK2)
SCAN: 103820586(ROCK2)
PMOA: 120505313(ROCK2)
OTC: 121344529(ROCK2)
PRUF: 121359156(ROCK2)
ATRC: 139596443(ROCK2)
MATE: 118685141(ROCK2)
MAEN: 136554876(ROCK2)
GFR: 102032829(ROCK2)
FAB: 101817597(ROCK2)
OMA: 130250621(ROCK2)
PHI: 102103730(ROCK2)
PMAJ: 107201732(ROCK2)
CCAE: 111925960(ROCK2)
CCW: 104685437(ROCK2)
CBRC: 103622782(ROCK2)
ACOE: 138108651(ROCK2)
ETL: 114061910(ROCK2)
ZAB: 102074600(ROCK2)
ZLE: 135445369(ROCK2)
ACHL: 103804574(ROCK2)
SVG: 106865106(ROCK2)
MMEA: 130576097(ROCK2)
HRT: 120750590(ROCK2)
SATI: 136358778(ROCK2)
CFAI: 136287317(ROCK2)
CCIC: 134042409(ROCK2)
FPG: 101916990(ROCK2)
FCH: 102053908(ROCK2)
FRS: 119149754(ROCK2)
CCRI: 104164488(ROCK2)
NNT: 104399807(ROCK2)
SHAB: 115609284(ROCK2)
ACUN: 113477643(ROCK2)
ANOC: 141955932(ROCK2)
SURA: 141940535(ROCK2)
TALA: 116964580(ROCK2)
ACHC: 115351142(ROCK2)
HALD: 104315556(ROCK2)
HLE: 104831236(ROCK2)
AGEN: 126046771
HHAR: 128151794(ROCK2)
BBUT: 142040836(ROCK2)
GCL: 127013996
CSTI: 104550202(ROCK2)
LDI: 104351587(ROCK2)
MNB: 103781637(ROCK2)
DPUB: 104308297(ROCK2)
PPUS: 135176946(ROCK2)
IIN: 128969016(ROCK2)
AVIT: 104274421(ROCK2)
BRHI: 104496671(ROCK2)
EGZ: 104127169(ROCK2)
NNI: 104013015(ROCK2)
PCRI: 104028422(ROCK2)
PCAO: 104044870
PARX: 142054347(ROCK2)
PADL: 103924034(ROCK2)
AFOR: 103895854(ROCK2)
FGA: 104084359(ROCK2)
CBOR: 142080132(ROCK2)
CBOY: 140650377(ROCK2)
MAME: 142408028(ROCK2)
CLV: 102084971(ROCK2)
CNIC: 135986735(ROCK2)
PGUU: 104462869
EHS: 104508170(ROCK2)
CMAC: 104483597(ROCK2)
CUCA: 104058169(ROCK2)
PCUR: 138717165(ROCK2)
TEO: 104379811(ROCK2)
GAME: 129204879(ROCK2)
OHA: 104332046(ROCK2)
ACAR: 104529708(ROCK2)
CPEA: 104395815(ROCK2)
CVF: 104290646(ROCK2)
RTD: 128906645(ROCK2)
CRID: 134513561(ROCK2)
LMIC: 141741336(ROCK2)
NARQ: 141468871(ROCK2)
AAM: 106494758(ROCK2)
AROW: 112972425(ROCK2)
NPD: 112945436(ROCK2)
TGT: 104577346(ROCK2)
DNE: 112981510(ROCK2)
SCAM: 104141834(ROCK2)
ASN: 102371812(ROCK2)
AMJ: 102572451(ROCK2)
CPOO: 109312087(ROCK2)
GGN: 109300164(ROCK2)
PSS: 102457091(ROCK2)
CIZ: 142011565(ROCK2)
CMY: 102934710(ROCK2)
CCAY: 125634574(ROCK2)
LKP: 140908580(ROCK2)
NDS: 141984583(ROCK2)
DCC: 119853191(ROCK2)
CPIC: 101952051(ROCK2)
TST: 117875524(ROCK2)
EOB: 135876177(ROCK2)
CABI: 116831963(ROCK2)
MRV: 120400793(ROCK2)
EMQ: 137150752(ROCK2)
ACS: 100562729(rock2)
ASAO: 132782673(ROCK2)
PVT: 110083697(ROCK2)
SUND: 121921009(ROCK2)
PMUR: 107294640(ROCK2)
CTIG: 120302849(ROCK2)
TSR: 106549506(ROCK2)
PGUT: 117674233(ROCK2)
PCAE: 139308966(ROCK2)
APRI: 131196144(ROCK2)
PTEX: 113432985(ROCK2)
NSS: 113416441(ROCK2)
VKO: 123017013(ROCK2)
PMUA: 114593802(ROCK2)
PRAF: 128410175(ROCK2)
ZVI: 118082382(ROCK2)
HCG: 128340480(ROCK2)
GJA: 107114818(ROCK2)
STOW: 125433814(ROCK2)
EMC: 129323385(ROCK2)
XLA: 100301953(rock2.S) 394289(rock2.L)
XTR: 100493965(rock2)
NPR: 108788599(ROCK2)
RTEM: 120936332(ROCK2)
ACAT: 141139353(ROCK2)
PADS: 140328152(ROCK2)
BBUF: 120997288(ROCK2)
BGAR: 122933631
DTC: 141083802(ROCK2)
HSQ: 130361339(ROCK2)
PCOB: 134909025(ROCK2)
PWL: 138296625(ROCK2)
MUO: 115467137(ROCK2)
GSH: 117356645(ROCK2)
DRE: 317747(rock2a) 321070(rock2b)
CCAR: 109044970 109059047 109083803(rock2b) 109101104(rock2a)
PTET: 122325531(rock2b) 122357107(rock2a)
LROH: 127175639(rock2a) 127183479(rock2b)
OMC: 131526545(rock2b) 131552115(rock2a)
PPRM: 120479411(rock2a) 120493647
RKG: 130073190(rock2a) 130102978(rock2b)
MAMB: 125277100(rock2a) 125278172(rock2b)
CERY: 137019056(rock2b) 137020656(rock2a)
TROS: 130558713(rock2a) 130565625
TDW: 130432203(rock2a) 130433915
MANU: 129415490(rock2a) 129429552(rock2b)
PDAB: 135749628(rock2b) 135786877(rock2a)
IPU: 108256302 108263171(rock2a)
IFU: 128605104(rock2a) 128621366
SMEO: 124397095(rock2a) 124400736
TFD: 113635696 113656145(rock2a)
TVC: 132846847(rock2a) 132854388
CGAR: 128510495 128528640(rock2a)
NGRA: 132881548 132889049(rock2a)
TRN: 134314724(rock2a) 134320488
AMEX: 103042784(rock2a) 103045824
CMAO: 118811008(rock2a) 118815917(rock2b)
EEE: 113576241(rock2) 113588491
CHAR: 105895559(rock2a) 105901497(rock2b)
SPIL: 134067050(rock2a) 134097599(rock2b)
ASAD: 121692803(rock2a) 121711536
TRU: 101067715 101068674(rock2)
TFS: 130515843 130539781(rock2a)
LCO: 104924772(rock2) 104926776
NCC: 104956174 104959841(rock2)
TBEN: 117486693(rock2a) 117492453
CGOB: 115003454 115027137(rock2)
PGEO: 117439791 117468191(rock2a)
GACU: 117539718(rock2a) 117556533
EMAC: 134876738 134881487(rock2a)
ELY: 117266968(rock2a) 117270871
EFO: 125896997 125901258(rock2a)
PLEP: 121954076(rock2a) 121955159
SLUC: 116065683(rock2a) 116066412
SVIT: 144535715(rock2a)
ECRA: 117935308(rock2a) 117961482
ESP: 116670634(rock2) 116705871
PFLV: 114546465(rock2) 114572998
PFLT: 120549181(rock2a)
GAT: 120807681 120832646(rock2a)
PPUG: 119194788 119227445(rock2a)
AFB: 129103071(rock2a) 129106890
CLUM: 117727562 117751367(rock2a)
PSWI: 130201873(rock2a) 130202379
CANA: 137785551 137788209(rock2a)
CVE: 137877654(rock2a) 137892339
AMIR: 142967924(rock2a)
MSAM: 119908433 119909923(rock2a)
SCHU: 122861382(rock2a) 122863432
EARM: 139297329(rock2a) 139301894
CUD: 121521529 121525969(rock2a)
SPUL: 138590903(rock2a) 138611505
LMIX: 132984887 132993618(rock2a)
HTC: 141801885 141806199(rock2a)
ALAT: 119012418 119034318(rock2a)
ASTR: 137610538(rock2a) 137613550
PKLU: 139211698(rock2a) 139217654
MZE: 101470679 101475967(rock2a)
ONL: 100701417 100709780(rock2)
OAU: 116324174 116325287(rock2a)
OML: 112158011(rock2a) 112158227
XMA: 102226221(rock2) 102230495
XCO: 114133879(rock2) 114158490
XHE: 116708718(rock2) 116734123
PRET: 103457451 103458704(rock2)
GAF: 122825782 122846660(rock2a)
PPRL: 129365267(rock2a) 129375452
CVG: 107081643 107094724(rock2)
CTUL: 119779147 119794686(rock2a)
GMU: 124855144(rock2a) 124882189
NFU: 107377468 107396125(rock2)
KMR: 108233468 108241747(rock2a)
ALIM: 106518444(rock2) 106522615
NWH: 119418273 119427162(rock2a)
LTU: 140266622 140270889(rock2a)
AOCE: 111566441 111568806(rock2a)
EJA: 138203334 138212534(rock2a)
BFRE: 138635070 138636068(rock2a)
MCEP: 124999124 125023444(rock2a)
POV: 109628087(rock2) 109636100
SSEN: 122782654(rock2a) 122784023
SSOE: 131443591 131444493(rock2a)
HHIP: 117755831(rock2a) 117757961
HSP: 118099269 118116262(rock2a)
PPLT: 128450397(rock2a) 128460277
SMAU: 118285968(rock2a) 118290327
LCF: 108895959 108896154(rock2a)
SDU: 111225444(rock2) 111239446
XGL: 120788791 120795120(rock2a)
HCQ: 109516807 109519530(rock2)
SSCV: 125981232(rock2a) 125990297
SBIA: 133496428 133513781(rock2a)
PEE: 133412540(rock2a) 133416884
PTAO: 133468003 133487668(rock2a)
BPEC: 110155690(rock2) 110172686
ENY: 140370157 140370452(rock2a)
MALB: 109953729 109972800(rock2)
BSPL: 114848338(rock2a) 114849611
SJO: 128375944(rock2a) 128376668
SSCO: 133997129 134000398(rock2a)
TTY: 137168898 137199180(rock2a)
GMH: 115534124 115544429(rock2)
ELS: 105021675 105029946(rock2)
OEP: 134025117 134027222(rock2a)
SFM: 108922224(rock2) 108929341
PKI: 111851538 111855542(rock2)
AANG: 118225980(rock2a) 118230628
AROT: 135236422(rock2a) 135256874
CCOG: 133128367 133129800(rock2a)
LOC: 102688837(rock2)
PSPA: 121315517 121317519(rock2a)
PSEX: 120526057(rock2a)
LCM: 102354777(ROCK2)
CMK: 103180944(rock2a)
RTP: 109915504(rock2a)
CPLA: 122541114(rock2a)
CPUN: 140465898
HOC: 132834548(rock2a)
SCAU: 119967553(rock2a)
STOZ: 140410553
LERI: 129697093(rock2a)
HAKA: 140733505
BFO: 118410101
BBEL: 109480927
CIN: 100176906
SCLV: 120346043
CLEP: 143450528
SPU: 579202(ROCK)
LPIC: 129280422
AJJ: 139973459
APLC: 110985687
ARUN: 117304329
AAMU: 139952117
AFIL: 140166832
AJC: 117116550
PFLL: 139133081
NVE: 5503002
EPA: 110232859
ATEN: 116305730
ADF: 107334472
AMIL: 114960351
MCAZ: 138045331
MFOO: 137974668
PDAM: 113681521
SPIS: 111337741
XEN: 124451840
HMG: 100201834
HSY: 130655486
RES: 135689297
CCLM: 134183279
 » show all
Reference
PMID:9933571
  Authors
Takahashi N, Tuiki H, Saya H, Kaibuchi K
  Title
Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24.
  Journal
Genomics 55:235-7 (1999)
DOI:10.1006/geno.1998.5344
  Sequence
[hsa:9475]
Reference
  Authors
Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K.
  Title
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.
  Journal
J Biol Chem 275:3577-82 (2000)
DOI:10.1074/jbc.275.5.3577
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