KEGG   ORTHOLOGY: K17388
Entry
K17388                      KO                                     
Symbol
ROCK2
Name
Rho-associated protein kinase 2 [EC:2.7.11.1]
Pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04071  Sphingolipid signaling pathway
map04270  Vascular smooth muscle contraction
map04310  Wnt signaling pathway
map04360  Axon guidance
map04510  Focal adhesion
map04530  Tight junction
map04611  Platelet activation
map04670  Leukocyte transendothelial migration
map04810  Regulation of actin cytoskeleton
map04921  Oxytocin signaling pathway
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05163  Human cytomegalovirus infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04071 Sphingolipid signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04024 cAMP signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04022 cGMP-PKG signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17388  ROCK2; Rho-associated protein kinase 2
   04530 Tight junction
    K17388  ROCK2; Rho-associated protein kinase 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K17388  ROCK2; Rho-associated protein kinase 2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K17388  ROCK2; Rho-associated protein kinase 2
   04670 Leukocyte transendothelial migration
    K17388  ROCK2; Rho-associated protein kinase 2
   04062 Chemokine signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K17388  ROCK2; Rho-associated protein kinase 2
  09158 Development and regeneration
   04360 Axon guidance
    K17388  ROCK2; Rho-associated protein kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K17388  ROCK2; Rho-associated protein kinase 2
   05205 Proteoglycans in cancer
    K17388  ROCK2; Rho-associated protein kinase 2
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K17388  ROCK2; Rho-associated protein kinase 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K17388  ROCK2; Rho-associated protein kinase 2
   05132 Salmonella infection
    K17388  ROCK2; Rho-associated protein kinase 2
   05131 Shigellosis
    K17388  ROCK2; Rho-associated protein kinase 2
   05135 Yersinia infection
    K17388  ROCK2; Rho-associated protein kinase 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17388  ROCK2; Rho-associated protein kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K17388  ROCK2; Rho-associated protein kinase 2
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K17388  ROCK2; Rho-associated protein kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K17388  ROCK2; Rho-associated protein kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   K17388  ROCK2; Rho-associated protein kinase 2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    K17388  ROCK2; Rho-associated protein kinase 2
Genes
HSA: 9475(ROCK2)
PTR: 470307(ROCK2)
PPS: 100969111(ROCK2)
GGO: 101134988(ROCK2)
PON: 100461801(ROCK2)
NLE: 100585294(ROCK2)
MCC: 708444(ROCK2)
MCF: 102133054(ROCK2)
CSAB: 103220805(ROCK2)
CATY: 105578625(ROCK2)
PANU: 101003099(ROCK2)
TGE: 112604719(ROCK2)
RRO: 104675191(ROCK2)
RBB: 108516461(ROCK2)
TFN: 117062719(ROCK2)
PTEH: 111532006(ROCK2)
CJC: 100408337(ROCK2)
SBQ: 101039371(ROCK2)
CSYR: 103267985(ROCK2)
MMUR: 105880217(ROCK2)
OGA: 100953342(ROCK2)
MMU: 19878(Rock2)
MCAL: 110306686(Rock2)
MPAH: 110324181(Rock2)
RNO: 25537(Rock2)
MCOC: 116080601(Rock2)
MUN: 110541556(Rock2)
CGE: 100767265(Rock2)
PLEU: 114698838(Rock2)
NGI: 103747607(Rock2)
HGL: 101724195(Rock2)
CPOC: 100713798(Rock2)
CCAN: 109684863(Rock2)
DORD: 105983611(Rock2)
DSP: 122108760(Rock2)
NCAR: 124962770
OCU: 100346837(ROCK2)
OPI: 101533973(ROCK2)
TUP: 102490242(ROCK2)
CFA: 482970(ROCK2)
VVP: 112927709(ROCK2)
VLG: 121490634(ROCK2)
AML: 100466003(ROCK2)
UMR: 103660117(ROCK2)
UAH: 113269955(ROCK2)
UAR: 123778572(ROCK2)
ELK: 111154090
LLV: 125108362
MPUF: 101681879(ROCK2)
ORO: 101372971(ROCK2)
EJU: 114205781(ROCK2)
ZCA: 113937156(ROCK2)
MLX: 118007595(ROCK2)
FCA: 101094501(ROCK2)
PYU: 121044101(ROCK2)
PBG: 122497462(ROCK2)
PTG: 102949986(ROCK2)
PPAD: 109268495(ROCK2)
AJU: 106977263(ROCK2)
HHV: 120231144(ROCK2)
BTA: 282041(ROCK2)
BOM: 102267122(ROCK2)
BIU: 109566382(ROCK2)
BBUB: 102409368(ROCK2)
CHX: 102181692(ROCK2)
OAS: 101103800(ROCK2)
ODA: 120851858(ROCK2)
CCAD: 122442064(ROCK2)
SSC: 397445(ROCK2)
CFR: 102512572(ROCK2)
CBAI: 105076019(ROCK2)
CDK: 105091254(ROCK2)
VPC: 102524824(ROCK2)
BACU: 102999355(ROCK2)
LVE: 103081507(ROCK2)
OOR: 101289250(ROCK2)
DLE: 111164467(ROCK2)
PCAD: 102994518(ROCK2)
PSIU: 116764174(ROCK2)
ECB: 100072339(ROCK2)
EPZ: 103557393(ROCK2)
EAI: 106846040(ROCK2)
MYB: 102254781(ROCK2)
MYD: 102763604(ROCK2)
MMYO: 118669273(ROCK2)
MLF: 102431516(ROCK2)
MNA: 107542396(ROCK2)
PKL: 118717047(ROCK2)
HAI: 109386644(ROCK2)
DRO: 112297718(ROCK2)
SHON: 118988767(ROCK2)
AJM: 119053927(ROCK2)
PDIC: 114498743(ROCK2)
PHAS: 123822396(ROCK2)
MMF: 118630612(ROCK2)
RFQ: 117033436(ROCK2)
PALE: 102897424(ROCK2)
PGIG: 120621957(ROCK2)
PVP: 105295461(ROCK2)
RAY: 107501194(ROCK2)
MJV: 108409101(ROCK2)
TOD: 119259551(ROCK2)
SARA: 101539253(ROCK2)
LAV: 100658857(ROCK2)
TMU: 101345959
DNM: 101428161
MDO: 100032706(ROCK2)
GAS: 123233446(ROCK2)
SHR: 100916865(ROCK2)
PCW: 110207655(ROCK2)
OAA: 100073941(ROCK2)
GGA: 374182(ROCK2)
PCOC: 116240378(ROCK2)
MGP: 100538826(ROCK2)
CJO: 107312208(ROCK2)
NMEL: 110395385(ROCK2)
APLA: 101792620(ROCK2)
ACYG: 106030727(ROCK2)
AFUL: 116487357(ROCK2)
TGU: 100221127(ROCK2)
LSR: 110467944(ROCK2)
SCAN: 103820586(ROCK2)
PMOA: 120505313(ROCK2)
OTC: 121344529(ROCK2)
PRUF: 121359156(ROCK2)
GFR: 102032829(ROCK2)
FAB: 101817597(ROCK2)
PHI: 102103730(ROCK2)
PMAJ: 107201732(ROCK2)
CCAE: 111925960(ROCK2)
CCW: 104685437(ROCK2)
ETL: 114061910(ROCK2)
ZAB: 102074600(ROCK2)
FPG: 101916990(ROCK2)
FCH: 102053908(ROCK2)
CLV: 102084971(ROCK2)
EGZ: 104127169(ROCK2)
NNI: 104013015(ROCK2)
ACUN: 113477643(ROCK2)
TALA: 116964580(ROCK2)
PADL: 103924034(ROCK2)
ACHC: 115351142(ROCK2)
AAM: 106494758(ROCK2)
AROW: 112972425(ROCK2)
NPD: 112945436(ROCK2)
DNE: 112981510(ROCK2)
ASN: 102371812(ROCK2)
AMJ: 102572451(ROCK2)
CPOO: 109312087(ROCK2)
GGN: 109300164(ROCK2)
PSS: 102457091(ROCK2)
CMY: 102934710(ROCK2)
CPIC: 101952051(ROCK2)
TST: 117875524(ROCK2)
CABI: 116831963(ROCK2)
MRV: 120400793(ROCK2)
ACS: 100562729(rock2)
PVT: 110083697(ROCK2)
SUND: 121921009(ROCK2)
PMUR: 107294640(ROCK2)
TSR: 106549506(ROCK2)
PGUT: 117674233(ROCK2)
VKO: 123017013(ROCK2)
PMUA: 114593802(ROCK2)
ZVI: 118082382(ROCK2)
GJA: 107114818(ROCK2)
STOW: 125433814(ROCK2)
XLA: 100301953(rock2.S) 394289(rock2.L)
XTR: 100493965(rock2)
NPR: 108788599(ROCK2)
RTEM: 120936332(ROCK2)
BBUF: 120997288(ROCK2)
BGAR: 122933631
DRE: 317747(rock2a) 321070(rock2b)
CCAR: 109044970 109101104(rock2)
PPRM: 120479411(rock2a) 120493647
MAMB: 125277100(rock2a) 125278172(rock2b)
IPU: 108256302 108263171(rock2a)
SMEO: 124397095(rock2a) 124400736
TFD: 113635696 113656145(rock2a)
EEE: 113576241(rock2) 113588491
TRU: 101067715 101068674(rock2)
LCO: 104924772(rock2) 104926776
NCC: 104956174 104959841(rock2)
CGOB: 115003454 115027137(rock2)
ELY: 117266968(rock2a) 117270871
PLEP: 121954076(rock2a) 121955159
SLUC: 116065683(rock2a) 116066412
ECRA: 117935308(rock2a) 117961482
PFLV: 114546465(rock2) 114572998
GAT: 120807681 120832646(rock2a)
PPUG: 119194788 119227445(rock2a)
MSAM: 119908433 119909923(rock2a)
CUD: 121521529 121525969(rock2a)
MZE: 101470679 101475967(rock2)
ONL: 100701417 100709780(rock2)
OAU: 116324174 116325287(rock2a)
OML: 112158011(rock2a) 112158227
XMA: 102226221(rock2) 102230495
XCO: 114133879(rock2) 114158490
XHE: 116708718(rock2) 116734123
PRET: 103457451 103458704(rock2)
GAF: 122825782 122846660(rock2a)
CVG: 107081643 107094724(rock2)
CTUL: 119779147 119794686(rock2a)
GMU: 124855144(rock2a) 124882189
NFU: 107377468 107396125(rock2)
KMR: 108233468 108241747(rock2a)
ALIM: 106518444(rock2) 106522615
NWH: 119418273 119427162(rock2a)
AOCE: 111566441 111568806(rock2)
POV: 109628087(rock2) 109636100
SSEN: 122782654(rock2a) 122784023
HHIP: 117755831(rock2a) 117757961
SDU: 111225444(rock2) 111239446
XGL: 120788791 120795120(rock2a)
HCQ: 109516807 109519530(rock2)
BPEC: 110155690(rock2) 110172686
MALB: 109953729 109972800(rock2)
ELS: 105021675 105029946(rock2)
SFM: 108922224(rock2) 108929341
PKI: 111851538 111855542(rock2)
AANG: 118225980(rock2a) 118230628
LOC: 102688837(rock2)
PSPA: 121315517 121317519(rock2a)
LCM: 102354777(ROCK2)
CMK: 103180944(rock2a)
RTP: 109915504
BFO: 118410101
BBEL: 109480927
CIN: 100176906
SCLV: 120346043
SPU: 579202(ROCK)
APLC: 110985687
AME: 100578506(ROCK2)
NVI: 100119770
API: 100164812
NLU: 111063994
HAME: 121868986
PCAN: 112574232
BGT: 106070649
GAE: 121376137
HRF: 124111882
HRJ: 124285935
CRG: 105325511
MYI: 110466108
PMAX: 117326171
MMER: 123525514
OBI: 106876226
OSN: 115215193
LAK: 106174871
EGL: EGR_03487
NVE: 5503002
EPA: 110232859
ATEN: 116305730
ADF: 107334472
AMIL: 114960351
PDAM: 113681521
SPIS: 111337741
XEN: 124451840
HMG: 100201834
 » show all
Reference
PMID:9933571
  Authors
Takahashi N, Tuiki H, Saya H, Kaibuchi K
  Title
Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24.
  Journal
Genomics 55:235-7 (1999)
DOI:10.1006/geno.1998.5344
  Sequence
[hsa:9475]
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