KEGG   DRUG: DinutuximabHelp
Entry
D10559                      Drug                                   

Name
Dinutuximab (USAN);
Unituxin (TN)
Product
Sequence
(Heavy chain)
EVQLLQSGPE LEKPGASVMI SCKASGSSFT GYNMNWVRQN IGKSLEWIGA IDPYYGGTSY
NQKFKGRATL TVDKSSSTAY MHLKSLTSED SAVYYCVSGM EYWGQGTSVT VSSASTKGPS
VFPLAPSSKS TSGGTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL QSSGLYSLSS
VVTVPSSSLG TQTYICNVNH KPSNTKVDKR VEPKSCDKTH TCPPCPAPEL LGGPSVFLFP
PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS
VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS REEMTKNQVS
LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS
CSVMHEALHN HYTQKSLSLS PGK
(Light chain)
EIVMTQSPAT LSVSPGERAT LSCRSSQSLV HRNGNTYLHW YLQKPGQSPK LLIHKVSNRF
SGVPDRFSGS GSGTDFTLKI SRVEAEDLGV YFCSQSTHVP PLTFGAGTKL ELKRTVAAPS
VFIFPPSDEQ LKSGTASVVC LLNNFYPREA KVQWKVDNAL QSGNSQESVT EQDSKDSTYS
LSSTLTLSKA DYEKHKVYAC EVTHQGLSSP VTKSFNRGEC
(dimer; disulfide bridge:H22-H96, H140-H196, H216-L220, H222-H'222, H225-H'225, H257-H317, H363-H421, H'22-H'96, H'140-H'196, H'216-L'220, H'257-H'317, H'363-H'421, L23-L93, L140-L200, L'23-L'93, L'140-L'200)
  Type
Peptide
Remark
ATC code: L01XC16
Product: D10559<US>
Efficacy
Antineoplastic, Immunomodulator, Anti-GD2 antibody
  Disease
Neuroblastoma [DS:H00043]
Comment
Monoclonal antibody
Target
GD2 [GL:G00114]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XC Monoclonal antibodies
     L01XC16 Dinutuximab
      D10559  Dinutuximab (USAN) <US>
Antineoplastics [br08340.html]
 D10559
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D10559
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10559
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10559
Pharmacogenomic biomarkers [br08341.html]
 Companion diagnostics
  D10559
BRITE hierarchy
Other DBs
CAS: 1363687-32-4
PubChem: 254741521
LinkDB All DBs

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