KEGG   DRUG: Amenamevir
Entry
D10564                      Drug                                   
Name
Amenamevir (JAN/INN);
Amenalief (TN)
Formula
C24H26N4O5S
Exact mass
482.1624
Mol weight
482.552
Structure
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inducer
 DG02891  CYP2B6 inducer
 DG02853  CYP3A/CYP3A4 inducer
Remark
Therapeutic category: 6250
ATC code: J05AX26
Product: D10564<JP>
Efficacy
Antiviral, Helicase-primase inhibitor
Target
Herpesvirus helicase-primase complex [KO:K25235 K25236 K25237]
  Pathway
ko03240  Viral replication
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551], CYP2B6 [HSA:1555]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AX Other antivirals
     J05AX26 Amenamevir
      D10564  Amenamevir (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D10564  Amenamevir (JAN/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D10564  Amenamevir
 Metabolizing enzyme inducer
  DG02891  CYP2B6 inducer
   D10564  Amenamevir
  DG02853  CYP3A/CYP3A4 inducer
   D10564  Amenamevir
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   Other inhibitor
    D10564  Amenamevir (JAN/INN) <JP>
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   Other inhibitor
    D10564  Amenamevir (JAN/INN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10564
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10564
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10564
Other DBs
CAS: 841301-32-4
PubChem: 254741526
LinkDB
KCF data

ATOM        34
            1   C8x C    11.9700   -6.3700
            2   C8y C    11.9700   -7.7700
            3   C8x C    13.1824   -8.4700
            4   C8x C    14.3949   -7.7700
            5   C8y C    14.3949   -6.3700
            6   C8x C    13.1824   -5.6700
            7   C8y C    10.7576   -8.4700
            8   N5x N     9.6185   -7.6884
            9   O2x O     8.5269   -8.5318
            10  C8x C     8.9916   -9.8306
            11  N5x N    10.3705   -9.7900
            12  N1b N    15.6260   -5.6590
            13  C5a C    16.8312   -6.3547
            14  C1b C    18.0135   -5.6719
            15  N1c N    19.2075   -6.3612
            16  O5a O    16.8316   -7.7696
            17  C5a C    20.3954   -5.6752
            18  C1y C    21.5865   -6.3629
            19  O5a O    20.3955   -4.2702
            20  C8y C    19.2077   -8.6797
            21  C8y C    17.9747   -9.3921
            22  C8x C    17.9751  -10.7921
            23  C8x C    19.1878  -11.4918
            24  C8x C    20.4208  -10.7793
            25  C8y C    20.4204   -9.3793
            26  C1x C    21.5866   -7.7697
            27  C1x C    22.7991   -8.4697
            28  S2x S    24.0115   -7.7696
            29  C1x C    24.0114   -6.3627
            30  C1x C    22.7989   -5.6628
            31  O3c O    25.2239   -7.0696
            32  O3c O    24.0115   -9.1696
            33  C1a C    16.7684   -8.6961
            34  C1a C    21.6469   -8.6705
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 1
            11   10  11 2
            12    7  11 1
            13    5  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   13  16 2
            18   15  17 1
            19   17  18 1
            20   17  19 2
            21   15  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   20  25 1
            28   18  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 1
            32   29  30 1
            33   18  30 1
            34   28  31 2
            35   28  32 2
            36   21  33 1
            37   25  34 1

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