KEGG   DRUG: AmenamevirHelp
Entry
D10564                      Drug                                   

Name
Amenamevir (JAN/INN);
Amenalief (TN)
Formula
C24H26N4O5S
Exact mass
482.1624
Mol weight
482.552
Structure
Mol fileKCF fileDB search
Class
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Metabolizing enzyme inducer
 DG02891  CYP2B6 inducer
 DG02853  CYP3A inducer
Remark
Therapeutic category: 6250
Product: D10564<JP>
Efficacy
Antiviral, Helicase-primase inhibitor
Target
Helicase-primase inhibitor for herpes virus [VG:2703395 1487286 1487696]
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551], CYP2B6 [HSA:1555]
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D10564  Amenamevir (JAN/INN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10564
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10564
BRITE hierarchy
Other DBs
CAS: 841301-32-4
PubChem: 254741526
LinkDB All DBs
KCF data Show

ATOM        34
            1   C8x C    11.9700   -6.3700
            2   C8y C    11.9700   -7.7700
            3   C8x C    13.1824   -8.4700
            4   C8x C    14.3949   -7.7700
            5   C8y C    14.3949   -6.3700
            6   C8x C    13.1824   -5.6700
            7   C8y C    10.7576   -8.4700
            8   N5x N     9.6185   -7.6884
            9   O2x O     8.5269   -8.5318
            10  C8x C     8.9916   -9.8306
            11  N5x N    10.3705   -9.7900
            12  N1b N    15.6260   -5.6590
            13  C5a C    16.8312   -6.3547
            14  C1b C    18.0135   -5.6719
            15  N1c N    19.2075   -6.3612
            16  O5a O    16.8316   -7.7696
            17  C5a C    20.3954   -5.6752
            18  C1y C    21.5865   -6.3629
            19  O5a O    20.3955   -4.2702
            20  C8y C    19.2077   -8.6797
            21  C8y C    17.9747   -9.3921
            22  C8x C    17.9751  -10.7921
            23  C8x C    19.1878  -11.4918
            24  C8x C    20.4208  -10.7793
            25  C8y C    20.4204   -9.3793
            26  C1x C    21.5866   -7.7697
            27  C1x C    22.7991   -8.4697
            28  S2x S    24.0115   -7.7696
            29  C1x C    24.0114   -6.3627
            30  C1x C    22.7989   -5.6628
            31  O3c O    25.2239   -7.0696
            32  O3c O    24.0115   -9.1696
            33  C1a C    16.7684   -8.6961
            34  C1a C    21.6469   -8.6705
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 1
            11   10  11 2
            12    7  11 1
            13    5  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   13  16 2
            18   15  17 1
            19   17  18 1
            20   17  19 2
            21   15  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   20  25 1
            28   18  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 1
            32   29  30 1
            33   18  30 1
            34   28  31 2
            35   28  32 2
            36   21  33 1
            37   25  34 1

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