KEGG   DRUG: Pitavastatin calcium hydrate
Entry
D10568                      Drug                                   
Name
Pitavastatin calcium hydrate (JP18)
Formula
(C25H23FNO4)2. 5H2O. Ca
Exact mass
970.3376
Mol weight
971.06
Structure
Simcomp
Class
Hypolipidemic agent
 DG01946  Hypolipidemic agent
  DG01660  HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 2189
ATC code: C10AA08
Chemical structure group: DG01838
Product (DG01838): D01862<JP/US> D10568<JP> D11092<US>
Product (mixture): D12438<JP>
Efficacy
Antihyperlipidemic, HMG-CoA reductase inhibitor
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA08 Pitavastatin
      D10568  Pitavastatin calcium hydrate (JP18) <JP>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Pitavastatin
    D10568  Pitavastatin calcium hydrate (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D10568  Pitavastatin calcium hydrate (JP18)
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01660  HMG-CoA reductase inhibitor
    DG01838  Pitavastatin
     D10568  Pitavastatin calcium hydrate
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG01838  Pitavastatin
    D10568  Pitavastatin calcium hydrate
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01946  Hypolipidemic agent
   D10568  Pitavastatin calcium hydrate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D10568  Pitavastatin calcium hydrate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D10568  Pitavastatin calcium hydrate
  D10568  Pitavastatin calcium tablets
  D10568  Pitavastatin calcium orally disintegrating tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10568
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01660  HMG-CoA reductase inhibitor
    DG01838  Pitavastatin
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG01838  Pitavastatin
Other DBs
PubChem: 254741530
LinkDB
KCF data

ATOM        68
            1   C8x C     6.9300  -11.5500
            2   C8x C     6.9300  -12.9500
            3   C8x C     8.1200  -13.6500
            4   C8y C     9.3800  -12.9500
            5   C8y C     9.3800  -11.5500
            6   C8x C     8.1200  -10.8500
            7   N5x N    10.5700  -13.6500
            8   C8y C    11.7600  -12.9500
            9   C8y C    11.7600  -11.5500
            10  C8y C    10.5700  -10.8500
            11  C8y C    10.5700   -9.4500
            12  C8x C    11.7600   -8.7500
            13  C8x C    11.7600   -7.3500
            14  C8y C    10.5700   -6.6500
            15  C8x C     9.3800   -7.3500
            16  C8x C     9.3800   -8.7500
            17  C2b C    12.9500  -10.8500
            18  C2b C    14.1400  -11.5500
            19  X   F    10.5700   -5.2500
            20  C1y C    12.9500  -13.6500
            21  C1c C    15.3300  -10.8500
            22  C1b C    16.5200  -11.5500
            23  C1c C    17.7100  -10.8500
            24  C1b C    18.9000  -11.5500
            25  O1a O    15.3300   -9.4500
            26  O1a O    17.7100   -9.4500
            27  C6a C    20.0900  -10.8500
            28  O6a O    21.2800  -11.5500 #-
            29  O6a O    20.0900   -9.4500
            30  C1x C    14.3500  -13.6500
            31  C1x C    13.6500  -14.8400
            32  Z   Ca   24.9200  -11.6200 #+
            33  O0  O    30.3100  -11.6900
            34  C8x C     6.9300  -11.5500
            35  C8x C     6.9300  -12.9500
            36  C8x C     8.1200  -13.6500
            37  C8y C     9.3800  -12.9500
            38  C8y C     9.3800  -11.5500
            39  C8x C     8.1200  -10.8500
            40  C8y C    10.5700  -10.8500
            41  C8y C    11.7600  -11.5500
            42  C8y C    11.7600  -12.9500
            43  N5x N    10.5700  -13.6500
            44  C1y C    12.9500  -13.6500
            45  C1x C    13.6500  -14.8400
            46  C1x C    14.3500  -13.6500
            47  C2b C    12.9500  -10.8500
            48  C2b C    14.1400  -11.5500
            49  C1c C    15.3300  -10.8500
            50  C1b C    16.5200  -11.5500
            51  C1c C    17.7100  -10.8500
            52  C1b C    18.9000  -11.5500
            53  C6a C    20.0900  -10.8500
            54  O6a O    21.2800  -11.5500 #-
            55  O6a O    20.0900   -9.4500
            56  O1a O    17.7100   -9.4500
            57  O1a O    15.3300   -9.4500
            58  C8y C    10.5700   -9.4500
            59  C8x C    11.7600   -8.7500
            60  C8x C    11.7600   -7.3500
            61  C8y C    10.5700   -6.6500
            62  C8x C     9.3800   -7.3500
            63  C8x C     9.3800   -8.7500
            64  X   F    10.5700   -5.2500
            65  O0  O    30.3100  -11.6900
            66  O0  O    30.3100  -11.6900
            67  O0  O    30.3100  -11.6900
            68  O0  O    30.3100  -11.6900
BOND        68
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12   10  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   11  16 1
            19    9  17 1
            20   17  18 2
            21   14  19 1
            22    8  20 1
            23   18  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   21  25 1 #Up
            28   23  26 1 #Up
            29   24  27 1
            30   27  28 1
            31   27  29 2
            32   31  30 1
            33   31  20 1
            34   20  30 1
            35   34  35 2
            36   35  36 1
            37   36  37 2
            38   37  38 1
            39   38  39 2
            40   34  39 1
            41   37  43 1
            42   43  42 2
            43   42  41 1
            44   41  40 2
            45   38  40 1
            46   40  58 1
            47   58  59 2
            48   59  60 1
            49   60  61 2
            50   61  62 1
            51   62  63 2
            52   58  63 1
            53   41  47 1
            54   47  48 2
            55   61  64 1
            56   42  44 1
            57   48  49 1
            58   49  50 1
            59   50  51 1
            60   51  52 1
            61   49  57 1 #Up
            62   51  56 1 #Up
            63   52  53 1
            64   53  54 1
            65   53  55 2
            66   45  46 1
            67   45  44 1
            68   44  46 1
BRACKET     1     5.9500  -15.1900    5.9500   -4.1300
            1    22.4700   -4.1300   22.4700  -15.1900
            1  2
 ORIGINAL  1    1   2   3   4   5   6  10   9   8   7  20  31  30  17  18  21
            1   22  23  24  27  28  29  26  25  11  12  13  14  15  16  19
 REPEAT    1   34  35  36  37  38  39  40  41  42  43  44  45  46  47  48  49
            1   50  51  52  53  54  55  56  57  58  59  60  61  62  63  64
            2    28.0000  -12.5300   28.0000  -10.7800
            2    30.9400  -10.7800   30.9400  -12.5300
            2  5
 ORIGINAL  2   33
 REPEAT    2   65  66  67  68

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