Entry |
|
Name |
Pitavastatin magnesium; Zypitamag (TN) |
Product |
|
Formula |
(C25H23FNO4)2. Mg
|
Exact mass |
864.3073
|
Mol weight |
865.21
|
Structure |
|
Simcomp |
|
Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
Remark |
Product (DG01838): | D01862<JP/US> D10568<JP> D11092<US> |
|
Efficacy |
Antihyperlipidemic, HMG-CoA reductase inhibitor |
Disease |
Primary hyperlipidemia [DS: H01635] Mixed dyslipidemia [DS: H01635] |
Target |
|
Pathway |
hsa00900 | Terpenoid backbone biosynthesis |
|
Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA08 Pitavastatin
D11092 Pitavastatin magnesium <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, HMG CoA Reductase Inhibitors
Pitavastatin
D11092 Pitavastatin magnesium
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG01838 Pitavastatin
D11092 Pitavastatin magnesium
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01838 Pitavastatin
D11092 Pitavastatin magnesium
Drug classes [BR:br08332]
Cardiovascular agent
DG01946 Hypolipidemic agent
D11092 Pitavastatin magnesium
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
HMGCR
D11092 Pitavastatin magnesium <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11092
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG01838 Pitavastatin
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01838 Pitavastatin
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 63
1 Z Mg 27.2300 -16.3800 #2+
2 C8x C 10.7800 -17.7100
3 C8x C 10.7800 -19.1100
4 C8x C 11.9700 -19.8100
5 C8y C 13.2300 -19.1100
6 C8y C 13.2300 -17.7100
7 C8x C 11.9700 -17.0100
8 N5x N 14.4200 -19.8100
9 C8y C 15.6100 -19.1100
10 C8y C 15.6100 -17.7100
11 C8y C 14.4200 -17.0100
12 C8y C 14.4200 -15.6100
13 C8x C 15.6100 -14.9100
14 C8x C 15.6100 -13.5100
15 C8y C 14.4200 -12.8100
16 C8x C 13.2300 -13.5100
17 C8x C 13.2300 -14.9100
18 C2b C 16.8000 -17.0100
19 C2b C 17.9900 -17.7100
20 X F 14.4200 -11.4100
21 C1y C 16.8000 -19.8100
22 C1c C 19.1800 -17.0100
23 C1b C 20.3700 -17.7100
24 C1c C 21.5600 -17.0100
25 C1b C 22.7500 -17.7100
26 O1a O 19.1800 -15.6100
27 O1a O 21.5600 -15.6100
28 C6a C 23.9400 -17.0100
29 O6a O 25.1300 -17.7100 #-
30 O6a O 23.9400 -15.6100
31 C1x C 18.2000 -19.8100
32 C1x C 17.5000 -21.0000
33 C8x C 10.7800 -17.7100
34 C8x C 10.7800 -19.1100
35 C8x C 11.9700 -19.8100
36 C8y C 13.2300 -19.1100
37 C8y C 13.2300 -17.7100
38 C8x C 11.9700 -17.0100
39 C8y C 14.4200 -17.0100
40 C8y C 15.6100 -17.7100
41 C8y C 15.6100 -19.1100
42 N5x N 14.4200 -19.8100
43 C1y C 16.8000 -19.8100
44 C1x C 17.5000 -21.0000
45 C1x C 18.2000 -19.8100
46 C2b C 16.8000 -17.0100
47 C2b C 17.9900 -17.7100
48 C1c C 19.1800 -17.0100
49 C1b C 20.3700 -17.7100
50 C1c C 21.5600 -17.0100
51 C1b C 22.7500 -17.7100
52 C6a C 23.9400 -17.0100
53 O6a O 25.1300 -17.7100 #-
54 O6a O 23.9400 -15.6100
55 O1a O 21.5600 -15.6100
56 O1a O 19.1800 -15.6100
57 C8y C 14.4200 -15.6100
58 C8x C 15.6100 -14.9100
59 C8x C 15.6100 -13.5100
60 C8y C 14.4200 -12.8100
61 C8x C 13.2300 -13.5100
62 C8x C 13.2300 -14.9100
63 X F 14.4200 -11.4100
BOND 68
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 5 8 1
8 8 9 2
9 9 10 1
10 10 11 2
11 6 11 1
12 11 12 1
13 12 13 2
14 13 14 1
15 14 15 2
16 15 16 1
17 16 17 2
18 12 17 1
19 10 18 1
20 18 19 2
21 15 20 1
22 9 21 1
23 19 22 1
24 22 23 1
25 23 24 1
26 24 25 1
27 22 26 1 #Up
28 24 27 1 #Up
29 25 28 1
30 28 29 1
31 28 30 2
32 32 31 1
33 32 21 1
34 21 31 1
35 33 34 2
36 34 35 1
37 35 36 2
38 36 37 1
39 37 38 2
40 33 38 1
41 36 42 1
42 42 41 2
43 41 40 1
44 40 39 2
45 37 39 1
46 39 57 1
47 57 58 2
48 58 59 1
49 59 60 2
50 60 61 1
51 61 62 2
52 57 62 1
53 40 46 1
54 46 47 2
55 60 63 1
56 41 43 1
57 47 48 1
58 48 49 1
59 49 50 1
60 50 51 1
61 48 56 1 #Up
62 50 55 1 #Up
63 51 52 1
64 52 53 1
65 52 54 2
66 44 45 1
67 44 43 1
68 43 45 1
BRACKET 1 10.4300 -21.4200 10.4300 -10.9900
1 25.8300 -10.9900 25.8300 -21.4200
1 2
ORIGINAL 1 2 3 4 5 6 7 11 10 9 8 21 32 31 18 19 22
1 23 24 25 28 29 30 27 26 12 13 14 15 16 17 20
REPEAT 1 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48
1 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63
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