KEGG   DRUG: Roxadustat
Entry
D10593                      Drug                                   

Name
Roxadustat (JAN/USAN/INN);
Evrenzo (TN)
Formula
C19H16N2O5
Exact mass
352.1059
Mol weight
352.3407
Structure
Class
Metabolizing enzyme substrate
 DG02918  CYP2C8 substrate
 DG02924  UGT substrate
  DG03188  UGT1A9 substrate
Transporter substrate
 DG01913  ABCG2 substrate
 DG02859  SLC22A6 substrate
 DG02860  SLC22A8 substrate
 DG02856  SLCO1B1 substrate
Transporter inhibitor
 DG02862  ABCG2 inhibitor
 DG02865  SLCO1B1 inhibitor
Remark
Therapeutic category: 3999
ATC code: B03XA05
Product: D10593<JP>
Efficacy
Anti-anemic, Prolyl hydroxylase inhibitor
Comment
Treatment of anemia
Target
EGLN (HPH) [HSA:54583 112398 112399] [KO:K09592]
  Pathway
hsa04066  HIF-1 signaling pathway
Metabolism
Enzyme: CYP2C8 [HSA:1558], UGT1A9 [HSA:54600]
Transporter: ABCG2 [HSA:9429], SLCO1B1 [HSA:10599], SLC22A6 [HSA:9356], SLC22A8 [HSA:9376]
Interaction
Transporter inhibition: ABCG2 [HSA:9429], SLCO1B1 [HSA:10599]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B03 ANTIANEMIC PREPARATIONS
   B03X OTHER ANTIANEMIC PREPARATIONS
    B03XA Other antianemic preparations
     B03XA05 Roxadustat
      D10593  Roxadustat (JAN/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D10593  Roxadustat (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   HIF hydroxylase
    EGLN (HPH)
     D10593  Roxadustat (JAN/USAN/INN) <JP>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10593
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10593
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10593
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10593
 Drug transporters
  D10593
Other DBs
CAS: 808118-40-3
PubChem: 254741555
ChEBI: 132774
ChEMBL: CHEMBL2338329
PDB-CCD: 8HO[PDBj]
LinkDB
KCF data

ATOM        26
            1   C8x C     5.3900  -15.4000
            2   C8x C     5.3900  -16.8000
            3   C8x C     6.5800  -17.5000
            4   C8x C     7.8400  -16.8000
            5   C8y C     7.8400  -15.4000
            6   C8x C     6.5800  -14.7000
            7   O2a O     9.0300  -14.7000
            8   C8y C    10.2200  -15.4000
            9   C8x C    10.2200  -16.8000
            10  C8x C    11.4800  -17.5000
            11  C8y C    12.6700  -16.8000
            12  C8y C    12.6700  -15.4000
            13  C8x C    11.4800  -14.7000
            14  C8y C    13.8600  -17.5000
            15  C8y C    15.1200  -16.8000
            16  N5x N    15.1200  -15.4000
            17  C8y C    13.8600  -14.7000
            18  C1a C    13.8600  -13.3000
            19  O1a O    13.8600  -18.9000
            20  C5a C    16.3100  -17.5000
            21  N1b N    17.5000  -16.8000
            22  O5a O    16.3100  -18.9000
            23  C1b C    18.6900  -17.5000
            24  C6a C    19.8800  -16.8000
            25  O6a O    21.0700  -17.5000
            26  O6a O    19.8800  -15.4000
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   11  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20   17  18 1
            21   14  19 1
            22   15  20 1
            23   20  21 1
            24   20  22 2
            25   21  23 1
            26   23  24 1
            27   24  25 1
            28   24  26 2

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