KEGG   DRUG: RoxadustatHelp
Entry
D10593                      Drug                                   

Name
Roxadustat (JAN/USAN/INN);
Evrenzo (TN)
Formula
C19H16N2O5
Exact mass
352.1059
Mol weight
352.3407
Structure
Mol fileKCF fileDB search
Remark
Therapeutic category: 3999
ATC code: B03XA05
Efficacy
Anti-anemic, Prolyl hydroxylase inhibitor
Comment
Treatment of anemia
Target
EGLN (HPH) [HSA:54583 112398 112399] [KO:K09592]
  Pathway
hsa04066  HIF-1 signaling pathway
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B03 ANTIANEMIC PREPARATIONS
   B03X OTHER ANTIANEMIC PREPARATIONS
    B03XA Other antianemic preparations
     B03XA05 Roxadustat
      D10593  Roxadustat (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D10593  Roxadustat (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   HIF hydroxylase
    EGLN (HPH)
     D10593  Roxadustat (JAN/USAN/INN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10593
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10593
BRITE hierarchy
Other DBs
CAS: 808118-40-3
PubChem: 254741555
ChEBI: 132774
ChEMBL: CHEMBL2338329
LinkDB All DBs
KCF data Show

ATOM        26
            1   C8x C     5.3900  -15.4000
            2   C8x C     5.3900  -16.8000
            3   C8x C     6.5800  -17.5000
            4   C8x C     7.8400  -16.8000
            5   C8y C     7.8400  -15.4000
            6   C8x C     6.5800  -14.7000
            7   O2a O     9.0300  -14.7000
            8   C8y C    10.2200  -15.4000
            9   C8x C    10.2200  -16.8000
            10  C8x C    11.4800  -17.5000
            11  C8y C    12.6700  -16.8000
            12  C8y C    12.6700  -15.4000
            13  C8x C    11.4800  -14.7000
            14  C8y C    13.8600  -17.5000
            15  C8y C    15.1200  -16.8000
            16  N5x N    15.1200  -15.4000
            17  C8y C    13.8600  -14.7000
            18  C1a C    13.8600  -13.3000
            19  O1a O    13.8600  -18.9000
            20  C5a C    16.3100  -17.5000
            21  N1b N    17.5000  -16.8000
            22  O5a O    16.3100  -18.9000
            23  C1b C    18.6900  -17.5000
            24  C6a C    19.8800  -16.8000
            25  O6a O    21.0700  -17.5000
            26  O6a O    19.8800  -15.4000
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   11  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20   17  18 1
            21   14  19 1
            22   15  20 1
            23   20  21 1
            24   20  22 2
            25   21  23 1
            26   23  24 1
            27   24  25 1
            28   24  26 2

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