KEGG   DRUG: BinimetinibHelp
Entry
D10604                      Drug                                   

Name
Binimetinib (JAN/USAN)
Product
Formula
C17H15BrF2N4O3
Exact mass
440.0296
Mol weight
441.2268
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
ATC code: L01XE41
Product: D10604<US>
Efficacy
Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor
Target
MAP2K (MEK) [HSA:5604 5605] [KO:K04368 K04369]
  Network
N10008  Kinase inhibitor to MEK downstream of BRAF mutation
  Pathway
hsa04010  MAPK signaling pathway
hsa05200  Pathways in cancer
hsa05218  Melanoma
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE41 Binimetinib
      D10604  Binimetinib (JAN/USAN) <US>
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   STE7 family
    MAP2K (MEK)
     D10604  Binimetinib (JAN/USAN) <US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D10604
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10604
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10604
Pharmacogenomic biomarkers [br08341.html]
 Companion diagnostics
  D10604
BRITE hierarchy
Other DBs
CAS: 606143-89-9
PubChem: 254741566
ChEMBL: CHEMBL3187723
LinkDB All DBs
KCF data Show

ATOM        27
            1   C8y C    12.9500  -16.7300
            2   C8y C    12.9500  -18.1300
            3   C8x C    14.1624  -18.8300
            4   C8y C    15.3749  -18.1300
            5   C8y C    15.3749  -16.7300
            6   C8y C    14.1624  -16.0300
            7   N4y N    16.7064  -18.5626
            8   C8x C    17.5293  -17.4300
            9   N5x N    16.7064  -16.2974
            10  X   F    14.1624  -14.6302
            11  N1b N    11.7376  -16.0300
            12  C5a C    11.7376  -18.8300
            13  N1b N    10.5421  -18.1396
            14  O5a O    11.7375  -20.2298
            15  O2a O     9.3547  -18.8251
            16  C1b C     8.1635  -18.1371
            17  C1b C     6.9740  -18.8238
            18  O1a O     5.7839  -18.1365
            19  C8y C    11.7375  -14.6302
            20  C8x C    12.9667  -13.9202
            21  C8x C    12.9665  -12.5202
            22  C8y C    11.7539  -11.8204
            23  C8x C    10.5247  -12.5304
            24  C8y C    10.5249  -13.9304
            25  X   Br   11.7538  -10.4300
            26  X   F     9.2942  -14.6414
            27  C1a C    17.1375  -19.8894
BOND        29
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    5   9 1
            11    6  10 1
            12    1  11 1
            13    2  12 1
            14   12  13 1
            15   12  14 2
            16   13  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   11  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   19  24 1
            27   22  25 1
            28   24  26 1
            29    7  27 1

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