KEGG   ORTHOLOGY: K04369
Entry
K04369                      KO                                     

Symbol
MAP2K2, MEK2
Name
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04066  HIF-1 signaling pathway
map04068  FoxO signaling pathway
map04071  Sphingolipid signaling pathway
map04072  Phospholipase D signaling pathway
map04140  Autophagy - animal
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04218  Cellular senescence
map04270  Vascular smooth muscle contraction
map04370  VEGF signaling pathway
map04371  Apelin signaling pathway
map04540  Gap junction
map04550  Signaling pathways regulating pluripotency of stem cells
map04613  Neutrophil extracellular trap formation
map04620  Toll-like receptor signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04720  Long-term potentiation
map04722  Neurotrophin signaling pathway
map04730  Long-term depression
map04810  Regulation of actin cytoskeleton
map04910  Insulin signaling pathway
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04917  Prolactin signaling pathway
map04919  Thyroid hormone signaling pathway
map04921  Oxytocin signaling pathway
map04926  Relaxin signaling pathway
map04929  GnRH secretion
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05132  Salmonella infection
map05135  Yersinia infection
map05160  Hepatitis C
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05211  Renal cell carcinoma
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05216  Thyroid cancer
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00523  Noonan syndrome and related disorders
H01745  Cardiofaciocutaneous syndrome
H02425  Erdheim-Chester disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04012 ErbB signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04014 Ras signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04015 Rap1 signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04370 VEGF signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04371 Apelin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04066 HIF-1 signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04068 FoxO signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04072 Phospholipase D signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04071 Sphingolipid signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04024 cAMP signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04022 cGMP-PKG signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04151 PI3K-Akt signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04150 mTOR signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09143 Cell growth and death
   04210 Apoptosis
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04218 Cellular senescence
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04550 Signaling pathways regulating pluripotency of stem cells
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04620 Toll-like receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04650 Natural killer cell mediated cytotoxicity
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04660 T cell receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04662 B cell receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04664 Fc epsilon RI signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04929 GnRH secretion
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04912 GnRH signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04915 Estrogen signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04917 Prolactin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04921 Oxytocin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04926 Relaxin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04935 Growth hormone synthesis, secretion and action
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04919 Thyroid hormone signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04916 Melanogenesis
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09156 Nervous system
   04720 Long-term potentiation
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04730 Long-term depression
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04722 Neurotrophin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05206 MicroRNAs in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05205 Proteoglycans in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05207 Chemical carcinogenesis - receptor activation
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05208 Chemical carcinogenesis - reactive oxygen species
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05230 Central carbon metabolism in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05231 Choline metabolism in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05225 Hepatocellular carcinoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05226 Gastric cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05214 Glioma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05216 Thyroid cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05221 Acute myeloid leukemia
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05220 Chronic myeloid leukemia
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05218 Melanoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05211 Renal cell carcinoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05219 Bladder cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05215 Prostate cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05213 Endometrial cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05224 Breast cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05223 Non-small cell lung cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05170 Human immunodeficiency virus 1 infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05161 Hepatitis B
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05160 Hepatitis C
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05164 Influenza A
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05163 Human cytomegalovirus infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05165 Human papillomavirus infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05135 Yersinia infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05022 Pathways of neurodegeneration - multiple diseases
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   01522 Endocrine resistance
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Other DBs
GO: 0004708
Genes
HSA: 5605(MAP2K2)
PTR: 456390(MAP2K2)
PPS: 100977025(MAP2K2)
GGO: 101126885
PON: 100450988(MAP2K2)
NLE: 100591827(MAP2K2)
MCC: 721821(MAP2K2)
MCF: 102140855(MAP2K2)
CSAB: 103233717(MAP2K2)
CATY: 105591800(MAP2K2)
PANU: 101004074(MAP2K2)
RRO: 104665487(MAP2K2)
RBB: 108512087(MAP2K2)
TFN: 117076490(MAP2K2)
PTEH: 111521954(MAP2K2)
CJC: 100393991(MAP2K2)
SBQ: 101036151(MAP2K2)
MMUR: 105873938(MAP2K2)
MMU: 26396(Map2k2)
MCAL: 110303196(Map2k2)
MPAH: 110326321(Map2k2)
RNO: 58960(Map2k2)
MCOC: 116076013(Map2k2)
MUN: 110555605(Map2k2)
CGE: 100774204(Map2k2)
PLEU: 114688121(Map2k2)
NGI: 103737276(Map2k2)
HGL: 101707562(Map2k2)
CCAN: 109687808(Map2k2)
TUP: 102483700(MAP2K2)
CFA: 611939(MAP2K2)
VVP: 112935545(MAP2K2)
VLG: 121495470(MAP2K2)
AML: 100465700(MAP2K2)
UMR: 103681834(MAP2K2)
UAH: 113242822(MAP2K2)
ORO: 101376586(MAP2K2)
ELK: 111161815
MPUF: 101678743(MAP2K2)
EJU: 114226331(MAP2K2)
MLX: 118004882(MAP2K2)
FCA: 101100281(MAP2K2)
PYU: 121021465(MAP2K2)
PBG: 122486708(MAP2K2)
PTG: 102956808(MAP2K2)
PPAD: 109255967(MAP2K2)
AJU: 106975474(MAP2K2)
HHV: 120242086(MAP2K2)
BTA: 510434(MAP2K2)
BOM: 102271710(MAP2K2)
BIU: 109561751(MAP2K2)
BBUB: 102401744(MAP2K2)
CHX: 102175285(MAP2K2)
OAS: 101113846(MAP2K2)
ODA: 120864821(MAP2K2)
SSC: 100525505(MAP2K2)
CFR: 102511209(MAP2K2)
CBAI: 105078209(MAP2K2)
CDK: 105105302(MAP2K2)
BACU: 103018627(MAP2K2)
LVE: 103090769(MAP2K2)
OOR: 101287162(MAP2K2)
DLE: 111165994(MAP2K2)
PCAD: 102994150(MAP2K2)
ECB: 100063190(MAP2K2)
EPZ: 103543290
EAI: 106832322(MAP2K2)
MYB: 102245571(MAP2K2)
MYD: 102757282(MAP2K2)
MMYO: 118657986(MAP2K2)
MNA: 107525695(MAP2K2)
HAI: 109388626(MAP2K2)
DRO: 112312483(MAP2K2)
SHON: 118984505(MAP2K2)
AJM: 119063754(MAP2K2)
MMF: 118615385(MAP2K2)
PALE: 102879034(MAP2K2)
PGIG: 120615382(MAP2K2)
RAY: 107510634(MAP2K2)
MJV: 108385046(MAP2K2)
TOD: 119240577(MAP2K2)
LAV: 100657587(MAP2K2)
TMU: 101341078
MDO: 100018044(MAP2K2)
SHR: 100917396(MAP2K2)
PCW: 110197417(MAP2K2)
OAA: 100087942(MAP2K2)
GGA: 396349(MAP2K2)
PCOC: 116235833(MAP2K2)
MGP: 100551337(MAP2K2)
CJO: 107325595(MAP2K2)
NMEL: 110388854(MAP2K2)
ACYG: 106044951(MAP2K2)
TGU: 100225195(MAP2K2)
LSR: 110478470(MAP2K2)
SCAN: 103824555(MAP2K2)
PMOA: 120499033(MAP2K2)
GFR: 102041148(MAP2K2)
FAB: 101820507(MAP2K2)
PHI: 102102285(MAP2K2)
PMAJ: 107215477(MAP2K2)
CCAE: 111940193(MAP2K2)
CCW: 104697410(MAP2K2)
ETL: 114068839(MAP2K2)
FPG: 101924296(MAP2K2)
FCH: 102049695(MAP2K2)
CLV: 102097053(MAP2K2)
EGZ: 104124397(MAP2K2)
NNI: 104018809(MAP2K2)
ACUN: 113489457(MAP2K2)
PADL: 103916484(MAP2K2)
AAM: 106492199(MAP2K2)
AROW: 112972305(MAP2K2)
NPD: 112949088(MAP2K2)
DNE: 112994722(MAP2K2)
ASN: 102375508(MAP2K2)
AMJ: 106736997(MAP2K2)
CPOO: 109324852(MAP2K2)
GGN: 109294689(MAP2K2)
PSS: 102457075(MAP2K2)
CMY: 102931357(MAP2K2)
CPIC: 101938330(MAP2K2)
TST: 117868754(MAP2K2)
CABI: 116819019(MAP2K2)
ACS: 100567176(map2k2)
PVT: 110072466(MAP2K2)
PBI: 103067786(MAP2K2)
PMUR: 107295320(MAP2K2)
TSR: 106555305(MAP2K2)
PGUT: 117656242(MAP2K2)
PMUA: 114588247(MAP2K2)
ZVI: 118086608(MAP2K2)
GJA: 107118240(MAP2K2)
DRE: 100002225(map2k2b) 563181(map2k2a)
IPU: 100528123(mp2k2) 108271291
AMEX: 103030512(map2k2)
TRU: 101070236(map2k2)
LCO: 104920827(map2k2) 104929670
NCC: 104963431(map2k2) 104965132
CGOB: 115007241(map2k2) 115022522
ELY: 117254181(map2k2a) 117271479(map2k2b)
PLEP: 121938842(map2k2a) 121951784(map2k2b)
SLUC: 116037337(map2k2b) 116063461(map2k2a)
ECRA: 117950204(map2k2a) 117954500(map2k2b)
GAT: 120816299(map2k2b) 120823910(map2k2a)
MSAM: 119900881(map2k2a) 119902918(map2k2b)
CUD: 121512343(map2k2a) 121520316(map2k2b)
OAU: 116310020(map2k2a) 116319019(map2k2b)
OLA: 101173453(map2k2)
OML: 112136869(map2k2a)
XMA: 102225775(map2k2)
XCO: 114151477(map2k2)
XHE: 116726343(map2k2)
PRET: 103463649(map2k2)
CVG: 107089725(map2k2)
CTUL: 119792552(map2k2a)
NFU: 107393294(map2k2)
KMR: 108230840(map2k2a)
ALIM: 106515024(map2k2)
AOCE: 111568133(map2k2) 111572311
CSEM: 103376625(map2k2)
POV: 109625750
SLAL: 111652614 111656372(map2k2)
XGL: 120791009(map2k2a) 120798627(map2k2b)
HCQ: 109532301
BPEC: 110173999(map2k2)
OMY: 100136127(tmek) 110508416 110524297 110530696(map2k2b)
SFM: 108919814 108921692(map2k2)
PKI: 111836645(map2k2) 111860367
AANG: 118226171(map2k2a) 118230058(map2k2b)
LOC: 102686784(map2k2)
PSPA: 121300828(map2k2a) 121301294
LCM: 102350370(MAP2K2)
CMK: 103183530(map2k2)
RTP: 109911767(map2k2)
HAZT: 108681758
RSAN: 119385920
ATEN: 116294634
HMG: 100213114
 » show all
Reference
PMID:8297798
  Authors
Brott BK, Alessandrini A, Largaespada DA, Copeland NG, Jenkins NA, Crews CM, Erikson RL
  Title
MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues.
  Journal
Cell Growth Differ 4:921-9 (1993)
  Sequence
[mmu:26396]
LinkDB

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