Entry |
|
Name |
Cobimetinib fumarate (USAN); Cobimetinib hemifumarate; Cotellic (TN) |
Product |
|
Formula |
(C21H21F3IN3O2)2. C4H4O4
|
Exact mass |
1178.1371
|
Mol weight |
1178.6922
|
Structure |

|
Remark |
Product (DG01825): | D10615<US> |
|
Efficacy |
Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor |
Disease |
Melanoma (BRAF mutation positive) [DS: H00038] |
Target |
|
Network |
N10008 | Kinase inhibitor to MEK downstream of BRAF mutation |
|
Pathway |
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EE Mitogen-activated protein kinase (MEK) inhibitors
L01EE02 Cobimetinib
D10615 Cobimetinib fumarate (USAN) <US>
USP drug classification [BR:br08302]
Antineoplastics
Molecular Target Inhibitors
Cobimetinib
D10615 Cobimetinib fumarate (USAN)
Target-based classification of drugs [BR:br08310]
Protein kinases
Serine/threonine kinases
STE group
MAP2K1 (MEK1)
D10615 Cobimetinib fumarate (USAN) <US>
MAP2K2 (MEK2)
D10615 Cobimetinib fumarate (USAN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D10615
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10615
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D10615
Pharmacogenomic biomarkers [br08341.html]
Somatic variations in targeted cancer therapies
D10615
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 68
1 C8x C 9.9388 -13.2290
2 C8y C 9.9388 -14.6289
3 C8y C 11.1287 -15.3288
4 C8y C 12.3186 -14.6289
5 C8y C 12.3186 -13.2290
6 C8x C 11.1287 -12.5290
7 C5a C 13.5785 -12.5290
8 N1y N 14.7685 -13.2290
9 O5a O 13.5785 -11.1291
10 X F 11.1287 -16.7287
11 X F 8.6789 -15.3288
12 N1b N 13.5785 -15.3288
13 C8y C 13.5785 -16.7287
14 C8x C 12.3186 -17.4287
15 C8x C 12.3186 -18.8286
16 C8y C 13.5785 -19.5285
17 C8x C 14.7685 -18.8286
18 C8y C 14.7685 -17.4287
19 X F 16.0284 -16.7287
20 X I 13.5785 -20.9284
21 C1x C 15.1184 -14.5589
22 C1z C 16.5183 -14.2089
23 C1x C 16.0984 -12.8790
24 C1y C 17.7082 -14.9089
25 N1x N 17.7082 -16.3088
26 C1x C 18.8982 -17.0087
27 C1x C 20.0881 -16.3088
28 C1x C 20.0881 -14.9089
29 C1x C 18.8982 -14.2089
30 O1a O 16.5183 -15.6088
31 O6a O 25.4782 -21.1384
32 C6a C 26.6905 -20.4385
33 C2b C 27.9029 -21.1384
34 C2b C 29.1153 -20.4385
35 C6a C 30.3276 -21.1384
36 O6a O 30.3276 -22.5383
37 O6a O 31.5399 -20.4385
38 O6a O 26.6905 -19.0386
39 C8x C 9.9388 -13.2290
40 C8y C 9.9388 -14.6289
41 C8y C 11.1287 -15.3288
42 C8y C 12.3186 -14.6289
43 C8y C 12.3186 -13.2290
44 C8x C 11.1287 -12.5290
45 C5a C 13.5785 -12.5290
46 N1y N 14.7685 -13.2290
47 C1x C 15.1184 -14.5589
48 C1z C 16.5183 -14.2089
49 C1x C 16.0984 -12.8790
50 C1y C 17.7082 -14.9089
51 N1x N 17.7082 -16.3088
52 C1x C 18.8982 -17.0087
53 C1x C 20.0881 -16.3088
54 C1x C 20.0881 -14.9089
55 C1x C 18.8982 -14.2089
56 O1a O 16.5183 -15.6088
57 O5a O 13.5785 -11.1291
58 N1b N 13.5785 -15.3288
59 C8y C 13.5785 -16.7287
60 C8x C 12.3186 -17.4287
61 C8x C 12.3186 -18.8286
62 C8y C 13.5785 -19.5285
63 C8x C 14.7685 -18.8286
64 C8y C 14.7685 -17.4287
65 X F 16.0284 -16.7287
66 X I 13.5785 -20.9284
67 X F 11.1287 -16.7287
68 X F 8.6789 -15.3288
BOND 73
1 31 32 1
2 32 33 1
3 33 34 2
4 34 35 1
5 35 36 1
6 35 37 2
7 32 38 2
8 1 2 2
9 2 3 1
10 3 4 2
11 4 5 1
12 5 6 2
13 1 6 1
14 5 7 1
15 7 8 1
16 7 9 2
17 3 10 1
18 2 11 1
19 4 12 1
20 12 13 1
21 13 14 2
22 14 15 1
23 15 16 2
24 16 17 1
25 17 18 2
26 13 18 1
27 18 19 1
28 16 20 1
29 8 21 1
30 21 22 1
31 22 23 1
32 8 23 1
33 24 22 1 #Down
34 24 25 1
35 25 26 1
36 26 27 1
37 27 28 1
38 28 29 1
39 24 29 1
40 22 30 1
41 39 40 2
42 40 41 1
43 41 42 2
44 42 43 1
45 43 44 2
46 39 44 1
47 43 45 1
48 45 46 1
49 45 57 2
50 41 67 1
51 40 68 1
52 42 58 1
53 58 59 1
54 59 60 2
55 60 61 1
56 61 62 2
57 62 63 1
58 63 64 2
59 59 64 1
60 64 65 1
61 62 66 1
62 46 47 1
63 47 48 1
64 48 49 1
65 46 49 1
66 50 48 1 #Down
67 50 51 1
68 51 52 1
69 52 53 1
70 53 54 1
71 54 55 1
72 50 55 1
73 48 56 1
BRACKET 1 6.0900 -22.4700 6.0900 -9.8700
1 22.1200 -9.8700 22.1200 -22.4700
1 2
ORIGINAL 1 1 2 3 4 5 6 7 8 21 22 23 24 25 26 27 28
1 29 30 9 12 13 14 15 16 17 18 19 20 10 11
REPEAT 1 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54
1 55 56 57 58 59 60 61 62 63 64 65 66 67 68
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