KEGG   DRUG: BimagrumabHelp
Entry
D10620                      Drug                                   

Name
Bimagrumab (JAN/USAN/INN)
Sequence
(heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT SSYINWVRQA PGQGLEWMGT INPVSGSTSY
AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCARGG WFDYWGQGTL VTVSSASTKG
PSVFPLAPSS KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL
SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KRVEPKSCDK THTCPPCPAP EAAGGPSVFL
FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV
VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSREEMTKNQ
VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV
FSCSVMHEAL HNHYTQKSLS LSPGK
(light chain)
QSALTQPASV SGSPGQSITI SCTGTSSDVG SYNYVNWYQQ HPGKAPKLMI YGVSKRPSGV
SNRFSGSKSG NTASLTISGL QAEDEADYYC GTFAGGSYYG VFGGGTKLTV LGQPKAAPSV
TLFPPSSEEL QANKATLVCL ISDFYPGAVT VAWKADSSPV KAGVETTTPS KQSNNKYAAS
SYLSLTPEQW KSHRSYSCQV THEGSTVEKT VAPTECS
(dimer; disulfide brige: H22-H96, H142-H198, H218-L216, H224-H'224, H227-H'227, H259-H319, H365-H423, H'22-H'96, H'142-H'198, H'218-L'216, H'259-H'319, H'365-H'423, L22-L90, L139-L198, L'22-L'90, L'139-L'198)
  Type
Peptide
Efficacy
Activin receptor type-2 modulator
Comment
Monoclonal antibody
Prevention and treatment of muscle wasting
Target
ACVR2A [HSA:92] [KO:K04670]
ACVR2B [HSA:93] [KO:K13596]
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor serine/threonine kinases (RSTK)
   TGFBR2 family
    ACVR2A
     D10620  Bimagrumab (JAN/USAN/INN)
    ACVR2B
     D10620  Bimagrumab (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 1356922-05-8
PubChem: 254741581
LinkDB All DBs

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