KEGG   DRUG: ElbasvirHelp
Entry
D10625                      Drug                                   

Name
Elbasvir (JAN/USAN/INN);
Erelsa (TN)
Formula
C49H55N9O7
Exact mass
881.4224
Mol weight
882.0171
Structure
Mol fileKCF fileDB search
Class
Antiviral
 DG01999  NS5A inhibitor
Transporter substrate
 DG01665  ABCB1(P-GP) substrate
Transporter inhibitor
 DG01622  ABCB1 (P-GP) inhibitor
 DG02862  ABCG2 (BCRP) inhibitor
Remark
Therapeutic category: 6250
Product: D10625<JP>
Product (mixture): D10778<US>
Efficacy
Antiviral, NS5A inhibitor
Comment
Treatment of Hepatis C
Target
HCV NS5A [KO:K22275]
  Pathway
ko05160  Hepatitis C
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Transporter: ABCB1 [HSA:5243]
Interaction
Transporter inhibition: ABCG2 [HSA:9429], ABCB1 [HSA:5243]
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D10625  Elbasvir (JAN/USAN/INN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10625
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10625
BRITE hierarchy
Other DBs
CAS: 1370468-36-2
PubChem: 254741586
ChEBI: 132967
LinkDB All DBs
KCF data Show

ATOM        65
            1   C1y C    11.4711  -24.0641
            2   N1y N    10.1419  -24.4839
            3   C1x C    10.1419  -25.8830
            4   C1x C    11.4711  -26.3027
            5   C1x C    12.3105  -25.1834
            6   C5a C     8.9527  -23.7843
            7   O5a O     7.7635  -24.4839
            8   C1c C     8.9527  -22.3852
            9   C1c C     7.7635  -21.6857
            10  C1a C     6.5742  -22.3153
            11  C1a C     7.7635  -20.2166
            12  C8y C    13.2199  -20.8462
            13  C8x C    11.8908  -20.4265
            14  N5x N    11.0513  -21.6157
            15  C8y C    11.8908  -22.7350
            16  N4x N    13.2199  -22.3153
            17  C8y C    14.4092  -20.1467
            18  C8x C    15.5984  -20.8462
            19  C8x C    16.8576  -20.1467
            20  C8y C    16.8576  -18.7476
            21  C8y C    15.6684  -18.0480
            22  C8x C    14.4092  -18.7476
            23  N4y N    17.8370  -17.8381
            24  C8y C    17.2773  -16.5790
            25  C8x C    15.9482  -16.7189
            26  C1y C    19.2361  -17.9781
            27  O2x O    20.0755  -16.8588
            28  C8y C    19.5159  -15.5996
            29  C8y C    18.1168  -15.3897
            30  C8x C    20.3553  -14.4104
            31  C8y C    19.7957  -13.1512
            32  C8x C    18.3966  -13.0113
            33  C8x C    17.5571  -14.1305
            34  C8y C    19.7957  -19.2372
            35  C8x C    21.1948  -19.3771
            36  C8x C    19.0262  -20.3565
            37  C8x C    19.5858  -21.6157
            38  C8x C    20.9849  -21.8256
            39  C8x C    21.7544  -20.6363
            40  C2y C    20.7751  -12.1718
            41  C1x C    22.1742  -12.3817
            42  N2x N    22.8038  -11.1225
            43  C2y C    21.8244  -10.1431
            44  N2x N    20.5652  -10.7727
            45  N1b N    10.2119  -21.6857
            46  C7a C    10.2119  -20.2166
            47  O7a O    11.4011  -19.5870
            48  O6a O     8.9527  -19.5171
            49  C1a C    11.4011  -18.1879
            50  C1y C    22.1742   -8.8140
            51  N1y N    23.4334   -8.2543
            52  C1x C    23.3634   -6.8552
            53  C1x C    22.0343   -6.5054
            54  C1x C    21.2648   -7.6947
            55  C5a C    24.6925   -8.8839
            56  C1c C    24.8325  -10.4930
            57  O5a O    25.9049   -8.1839
            58  C1c C    26.0449  -11.1930
            59  C1a C    27.2574  -10.4930
            60  C1a C    26.0449  -12.5930
            61  N1b N    23.6200  -11.1930
            62  C7a C    23.6200  -12.5930
            63  O7a O    22.6301  -13.5829
            64  O6a O    24.8325  -13.2930
            65  C1a C    22.6301  -14.9829
BOND        73
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     6   2 1
            7     6   7 2
            8     6   8 1
            9     9  10 1
            10    9  11 1
            11    8   9 1
            12   12  13 2
            13   13  14 1
            14   14  15 2
            15   15  16 1
            16   12  16 1
            17   12  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   17  22 1
            24   20  23 1
            25   23  24 1
            26   24  25 2
            27   21  25 1
            28   23  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 2
            32   24  29 1
            33   28  30 1
            34   30  31 2
            35   31  32 1
            36   32  33 2
            37   29  33 1
            38   34  35 1
            39   34  36 2
            40   36  37 1
            41   37  38 2
            42   38  39 1
            43   35  39 2
            44   26  34 1 #Up
            45   31  40 1
            46   40  41 1
            47   41  42 1
            48   42  43 2
            49   43  44 1
            50   40  44 2
            51    1  15 1 #Down
            52   45  46 1
            53   46  47 1
            54   46  48 2
            55   47  49 1
            56    8  45 1 #Down
            57   50  51 1
            58   51  52 1
            59   52  53 1
            60   53  54 1
            61   50  54 1
            62   51  55 1
            63   55  56 1
            64   50  43 1 #Down
            65   55  57 2
            66   56  58 1
            67   58  59 1
            68   58  60 1
            69   61  62 1
            70   62  63 1
            71   62  64 2
            72   63  65 1
            73   56  61 1 #Down

» Japanese version   » Back

DBGET integrated database retrieval system