KEGG   DRUG: Bempedoic acidHelp
Entry
D10691                      Drug                                   

Name
Bempedoic acid (USAN/INN);
Nexletol (TN)
Product
Formula
C19H36O5
Exact mass
344.2563
Mol weight
344.4861
Structure
Mol fileKCF fileDB search
Remark
ATC code: C10AX15
Product: D10691<US>
Efficacy
Antidyslipidemia
  Disease
Heterozygous familial hypercholesterolemia [DS:H00155]
Comment
Treatment of dyslipidemia
Target
ACLY (ACL) [HSA:47] [KO:K01648]
  Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa01100  Metabolic pathways
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AX Other lipid modifying agents
     C10AX15 Bempedoic acid
      D10691  Bempedoic acid (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   ATP citrate synthase
    ACLY (ACL)
     D10691  Bempedoic acid (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10691
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10691
BRITE hierarchy
Other DBs
CAS: 738606-46-7
PubChem: 254741652
ChEMBL: CHEMBL3545313
LinkDB All DBs
KCF data Show

ATOM        24
            1   C6a C    11.4100  -16.6600
            2   C1d C    12.6224  -17.3600
            3   C1b C    13.8349  -16.6600
            4   C1b C    15.0473  -17.3600
            5   C1b C    16.2597  -16.6600
            6   C1b C    17.4722  -17.3600
            7   C1b C    18.6846  -16.6600
            8   C1c C    19.8971  -17.3600
            9   C1b C    21.1096  -16.6600
            10  C1b C    22.3220  -17.3600
            11  C1b C    23.5345  -16.6600
            12  C1b C    24.7469  -17.3600
            13  O6a O    10.1976  -17.3600
            14  C1a C    11.9101  -18.6423
            15  C1a C    13.3224  -18.5725
            16  O1a O    19.8971  -18.7600
            17  C1b C    25.9593  -16.6600
            18  C1d C    27.1717  -17.3600
            19  C6a C    28.3842  -16.6600
            20  O6a O    29.5966  -17.3600
            21  O6a O    28.3842  -15.2600
            22  O6a O    11.4100  -15.2600
            23  C1a C    26.4717  -18.5725
            24  C1a C    27.8717  -18.5725
BOND        23
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12    1  13 1
            13    2  14 1
            14    2  15 1
            15    8  16 1
            16   12  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   19  21 2
            21    1  22 2
            22   18  23 1
            23   18  24 1

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