Homo sapiens (human): 47
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Entry
47 CDS
T01001
Symbol
ACLY, ACL, ATPCL, CLATP
Name
(RefSeq) ATP citrate lyase
KO
K01648
ATP citrate (pro-S)-lyase [EC:
2.3.3.8
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00020
Citrate cycle (TCA cycle)
hsa01100
Metabolic pathways
Network
nt06031
Citrate cycle and pyruvate metabolism
Element
N01604
Citrate cycle, first carbon oxidation
Drug target
Bempedoic acid:
D10691
<US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
47 (ACLY)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
47 (ACLY)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.8 ATP citrate synthase
47 (ACLY)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
47 (ACLY)
Exosomal proteins of bladder cancer cells
47 (ACLY)
Exosomal proteins of melanoma cells
47 (ACLY)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Citrate_synth_N
Citrate_bind
Citrate_synt
Ligase_CoA
CoA_binding
ATP-grasp_2
Succ_CoA_lig
Motif
Other DBs
NCBI-GeneID:
47
NCBI-ProteinID:
NP_001087
OMIM:
108728
HGNC:
115
Ensembl:
ENSG00000131473
UniProt:
P53396
Structure
PDB
PDBj
LinkDB
All DBs
Position
17:complement(41866917..41930545)
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AA seq
1101 aa
AA seq
DB search
MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPD
QLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFY
VCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEI
LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPP
PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE
LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRA
IRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALG
HRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVP
SPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQK
FYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEG
IPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYV
SRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIG
GTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALK
EAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASF
MTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADH
GPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFV
NKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPN
LILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLK
QGLYRHPWDDISYVLPEHMSM
NT seq
3306 nt
NT seq
+upstream
nt +downstream
nt
atgtcggccaaggcaatttcagagcagacgggcaaagaactcctttacaagttcatctgt
accacctcagccatccagaatcggttcaagtatgctcgggtcactcctgacacagactgg
gcccgcttgctgcaggaccacccctggctgctcagccagaacttggtagtcaagccagac
cagctgatcaaacgtcgtggaaaacttggtctcgttggggtcaacctcactctggatggg
gtcaagtcctggctgaagccacggctgggacaggaagccacagttggcaaggccacaggc
ttcctcaagaactttctgatcgagcccttcgtcccccacagtcaggctgaggagttctat
gtctgcatctatgccacccgagaaggggactacgtcctgttccaccacgaggggggtgtg
gacgtgggtgatgtggacgccaaggcccagaagctgcttgttggcgtggatgagaaactg
aatcctgaggacatcaaaaaacacctgttggtccacgcccctgaagacaagaaagaaatt
ctggccagttttatctccggcctcttcaatttctacgaggacttgtacttcacctacctc
gagatcaatccccttgtagtgaccaaagatggagtctatgtccttgacttggcggccaag
gtggacgccactgccgactacatctgcaaagtgaagtggggtgacatcgagttccctccc
cccttcgggcgggaggcatatccagaggaagcctacattgcagacctcgatgccaaaagt
ggggcaagcctgaagctgaccttgctgaaccccaaagggaggatctggaccatggtggcc
gggggtggcgcctctgtcgtgtacagcgataccatctgtgatctagggggtgtcaacgag
ctggcaaactatggggagtactcaggcgcccccagcgagcagcagacctatgactatgcc
aagactatcctctccctcatgacccgagagaagcacccagatggcaagatcctcatcatt
ggaggcagcatcgcaaacttcaccaacgtggctgccacgttcaagggcatcgtgagagca
attcgagattaccagggccccctgaaggagcacgaagtcacaatctttgtccgaagaggt
ggccccaactatcaggagggcttacgggtgatgggagaagtcgggaagaccactgggatc
cccatccatgtctttggcacagagactcacatgacggccattgtgggcatggccctgggc
caccggcccatccccaaccagccacccacagcggcccacactgcaaacttcctcctcaac
gccagcgggagcacatcgacgccagcccccagcaggacagcatctttttctgagtccagg
gccgatgaggtggcgcctgcaaagaaggccaagcctgccatgccacaagattcagtccca
agtccaagatccctgcaaggaaagagcaccaccctcttcagccgccacaccaaggccatt
gtgtggggcatgcagacccgggccgtgcaaggcatgctggactttgactatgtctgctcc
cgagacgagccctcagtggctgccatggtctaccctttcactggggaccacaagcagaag
ttttactgggggcacaaagagatcctgatccctgtcttcaagaacatggctgatgccatg
aggaagcatccggaggtagatgtgctcatcaactttgcctctctccgctctgcctatgac
agcaccatggagaccatgaactatgcccagatccggaccatcgccatcatagctgaaggc
atccctgaggccctcacgagaaagctgatcaagaaggcggaccagaagggagtgaccatc
atcggacctgccactgttggaggcatcaagcctgggtgctttaagattggcaacacaggt
gggatgctggacaacatcctggcctccaaactgtaccgcccaggcagcgtggcctatgtc
tcacgttccggaggcatgtccaacgagctcaacaatatcatctctcggaccacggatggc
gtctatgagggcgtggccattggtggggacaggtacccgggctccacattcatggatcat
gtgttacgctatcaggacactccaggagtcaaaatgattgtggttcttggagagattggg
ggcactgaggaatataagatttgccggggcatcaaggagggccgcctcactaagcccatc
gtctgctggtgcatcgggacgtgtgccaccatgttctcctctgaggtccagtttggccat
gctggagcttgtgccaaccaggcttctgaaactgcagtagccaagaaccaggctttgaag
gaagcaggagtgtttgtgccccggagctttgatgagcttggagagatcatccagtctgta
tacgaagatctcgtggccaatggagtcattgtacctgcccaggaggtgccgcccccaacc
gtgcccatggactactcctgggccagggagcttggtttgatccgcaaacctgcctcgttc
atgaccagcatctgcgatgagcgaggacaggagctcatctacgcgggcatgcccatcact
gaggtcttcaaggaagagatgggcattggcggggtcctcggcctcctctggttccagaaa
aggttgcctaagtactcttgccagttcattgagatgtgtctgatggtgacagctgatcac
gggccagccgtctctggagcccacaacaccatcatttgtgcgcgagctgggaaagacctg
gtctccagcctcacctcggggctgctcaccatcggggatcggtttgggggtgccttggat
gcagcagccaagatgttcagtaaagcctttgacagtggcattatccccatggagtttgtg
aacaagatgaagaaggaagggaagctgatcatgggcattggtcaccgagtgaagtcgata
aacaacccagacatgcgagtgcagatcctcaaagattacgtcaggcagcacttccctgcc
actcctctgctcgattatgcactggaagtagagaagattaccacctcgaagaagccaaat
cttatcctgaatgtagatggtctcatcggagtcgcatttgtagacatgcttagaaactgt
gggtcctttactcgggaggaagctgatgaatatattgacattggagccctcaatggcatc
tttgtgctgggaaggagtatggggttcattggacactatcttgatcagaagaggctgaag
caggggctgtatcgtcatccgtgggatgatatttcatatgttcttccggaacacatgagc
atgtaa
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