KEGG   DRUG: PemafibrateHelp
Entry
D10711                      Drug                                   

Name
Pemafibrate (JAN);
Parmodia (TN)
Formula
C28H30N2O6
Exact mass
490.2104
Mol weight
490.5476
Structure
Mol fileKCF fileDB search
Class
Metabolizing enzyme substrate
 DG02918  CYP2C8 substrate
 DG01642  CYP2C9 substrate
 DG01633  CYP3A substrate
Transporter substrate
 DG02856  SLCO1B1 (OATP1B1) substrate
 DG02932  SLCO1B3 (OATP1B3) substrate
Remark
Therapeutic category: 2183
Product: D10711<JP>
Efficacy
Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated receptor (PPAR) alpha agonist
Target
NR1C1 (PPARA) [HSA:5465] [KO:K07294]
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551], CYP2C9 [HSA:1559], CYP2C8 [HSA:1558]
Transporter: SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234]
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2183  Clofibrates
     D10711  Pemafibrate (JAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C1 (PPARA)
     D10711  Pemafibrate (JAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10711
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10711
BRITE hierarchy
Other DBs
CAS: 848259-27-8
PubChem: 254741672
ChEMBL: CHEMBL247951
LinkDB All DBs
KCF data Show

ATOM        36
            1   C8x C     4.6200  -17.0100
            2   C8x C     4.6200  -18.4100
            3   C8x C     5.8324  -19.1100
            4   C8y C     7.0449  -18.4100
            5   C8y C     7.0449  -17.0100
            6   C8x C     5.8324  -16.3100
            7   N5x N     8.3764  -18.8426
            8   C8y C     9.1993  -17.7100
            9   O2x O     8.3764  -16.5774
            10  N1c N    10.5700  -17.7100
            11  C1b C    11.2700  -18.9224
            12  C1b C    11.2700  -16.4976
            13  C8y C    12.6698  -16.4976
            14  C8x C    13.3797  -17.7268
            15  C8x C    14.7797  -17.7266
            16  C8x C    15.4796  -16.5141
            17  C8y C    14.7697  -15.2849
            18  C8x C    13.3697  -15.2851
            19  O2a O    15.4806  -14.0537
            20  C1c C    16.8699  -14.0539
            21  C1b C    17.5631  -12.8536
            22  C6a C    17.5768  -15.2785
            23  C1a C    18.9698  -12.8538
            24  O6a O    18.9699  -15.2785
            25  C1b C    12.6698  -18.9224
            26  C1b C    13.3603  -20.1180
            27  O2a O    14.7697  -20.1180
            28  C8y C    15.4577  -21.3095
            29  C8x C    14.7735  -22.4945
            30  C8x C    15.4735  -23.7069
            31  C8y C    16.8735  -23.7069
            32  C8x C    17.5577  -22.5219
            33  C8x C    16.8577  -21.3094
            34  O2a O    17.5828  -24.9350
            35  C1a C    18.9699  -24.9346
            36  O6a O    16.8830  -16.4798
BOND        39
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   10  12 1
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   17  19 1
            22   19  20 1
            23   20  21 1
            24   20  22 1 #Down
            25   21  23 1
            26   22  24 2
            27   11  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   31  32 1
            35   32  33 2
            36   28  33 1
            37   31  34 1
            38   34  35 1
            39   22  36 1

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