KEGG   DRUG: PemafibrateHelp
Entry
D10711                      Drug                                   

Name
Pemafibrate (JAN);
Parmodia (TN)
Formula
C28H30N2O6
Exact mass
490.2104
Mol weight
490.5476
Structure
Mol fileKCF fileDB search
Class
Enzyme substrate
 DG01642  CYP2C9 substrate
Transporter substrate
 DG02856  SLCO1B1 (OATP1B1) substrate
Remark
Therapeutic category: 2183
Product: D10711<JP>
Efficacy
Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated receptor (PPAR) alpha agonist
Target
NR1C1 (PPARA) [HSA:5465] [KO:K07294]
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551], CYP2C9 [HSA:1559], CYP2C8 [HSA:1558]
Transporter: SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234]
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2183  Clofibrates
     D10711  Pemafibrate (JAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C1 (PPARA)
     D10711  Pemafibrate (JAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10711
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10711
BRITE hierarchy
Other DBs
CAS: 848259-27-8
PubChem: 254741672
ChEMBL: CHEMBL247951
LinkDB All DBs
KCF data Show

ATOM        36
            1   C8x C     4.6200  -17.0100
            2   C8x C     4.6200  -18.4100
            3   C8x C     5.8324  -19.1100
            4   C8y C     7.0449  -18.4100
            5   C8y C     7.0449  -17.0100
            6   C8x C     5.8324  -16.3100
            7   N5x N     8.3764  -18.8426
            8   C8y C     9.1993  -17.7100
            9   O2x O     8.3764  -16.5774
            10  N1c N    10.5700  -17.7100
            11  C1b C    11.2700  -18.9224
            12  C1b C    11.2700  -16.4976
            13  C8y C    12.6698  -16.4976
            14  C8x C    13.3797  -17.7268
            15  C8x C    14.7797  -17.7266
            16  C8x C    15.4796  -16.5141
            17  C8y C    14.7697  -15.2849
            18  C8x C    13.3697  -15.2851
            19  O2a O    15.4806  -14.0537
            20  C1c C    16.8699  -14.0539
            21  C1b C    17.5631  -12.8536
            22  C6a C    17.5768  -15.2785
            23  C1a C    18.9698  -12.8538
            24  O6a O    18.9699  -15.2785
            25  C1b C    12.6698  -18.9224
            26  C1b C    13.3603  -20.1180
            27  O2a O    14.7697  -20.1180
            28  C8y C    15.4577  -21.3095
            29  C8x C    14.7735  -22.4945
            30  C8x C    15.4735  -23.7069
            31  C8y C    16.8735  -23.7069
            32  C8x C    17.5577  -22.5219
            33  C8x C    16.8577  -21.3094
            34  O2a O    17.5828  -24.9350
            35  C1a C    18.9699  -24.9346
            36  O6a O    16.8830  -16.4798
BOND        39
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   10  12 1
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   17  19 1
            22   19  20 1
            23   20  21 1
            24   20  22 1 #Down
            25   21  23 1
            26   22  24 2
            27   11  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   31  32 1
            35   32  33 2
            36   28  33 1
            37   31  34 1
            38   34  35 1
            39   22  36 1

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