KEGG   DRUG: Talazoparib tosylate
Entry
D10733                      Drug                                   
Name
Talazoparib tosylate (USAN);
Talazoparib tosilate (JAN);
Talzenna (TN)
Product
TALZENNA (Pfizer Laboratories Div Pfizer), TALZENNA (Pfizer Laboratories Div Pfizer), TALZENNA (U.S. Pharmaceuticals)
Formula
C19H14F2N6O. C7H8O3S
Exact mass
552.1391
Mol weight
552.55
Structure
Class
Antineoplastic
 DG02942  PARP inhibitor
Remark
Therapeutic category: 4291
ATC code: L01XK04
Chemical structure group: DG01865
Product (DG01865): D10733<JP/US>
Efficacy
Antineoplastic, PARP inhibitor
  Disease
Breast cancer (BRCA mutated, HER2 negative) [DS:H00031]
Prostate cancer, castration-resistant (HRR gene mutated) [DS:H00024]
Comment
Treatment of solid tumors and hematological malignancies
Target
PARP1 [HSA:142] [KO:K24070]
PARP2 [HSA:10038] [KO:K28005]
  Pathway
hsa03410  Base excision repair
hsa04064  NF-kappa B signaling pathway
hsa04210  Apoptosis
hsa04217  Necroptosis
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XK Poly (ADP-ribose) polymerase (PARP) inhibitors
     L01XK04 Talazoparib
      D10733  Talazoparib tosylate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Poly (ADP-ribose) Polymerase Inhibitors
    Talazoparib
     D10733  Talazoparib tosylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D10733  Talazoparib tosylate (USAN); Talazoparib tosilate (JAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG02942  PARP inhibitor
   DG01865  Talazoparib
    D10733  Talazoparib tosylate
Drug classes [BR:br08332]
 Antineoplastic
  DG02942  PARP inhibitor
   D10733  Talazoparib tosylate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Pentosyltransferases
    PARP1
     D10733  Talazoparib tosylate (USAN) <JP/US>
    PARP2
     D10733  Talazoparib tosylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10733
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10733
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10733
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10733
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D10733
Drug groups [BR:br08330]
 Antineoplastic
  DG02942  PARP inhibitor
   DG01865  Talazoparib
Other DBs
CAS: 1373431-65-2
PubChem: 254741694
LinkDB
KCF data

ATOM        39
            1   C8y C    17.5000  -14.9800
            2   C8x C    18.2000  -16.1000
            3   C8y C    19.6000  -16.1700
            4   C8y C    20.3000  -14.9800
            5   C8y C    19.6000  -13.7200
            6   C8x C    18.2000  -13.7200
            7   C8y C    21.7000  -14.9100
            8   N5x N    22.4000  -13.7200
            9   N4x N    21.7000  -12.5300
            10  C8y C    20.3000  -12.5300
            11  C1y C    21.7000  -17.3600
            12  C1y C    22.4000  -16.1700
            13  X   F    16.1000  -14.9800
            14  C8y C    22.4000  -18.5500
            15  C8x C    21.7000  -19.8100
            16  C8x C    22.4000  -21.0000
            17  C8y C    23.8000  -21.0000
            18  C8x C    24.5000  -19.8100
            19  C8x C    23.8000  -18.5500
            20  X   F    24.5700  -22.1900
            21  C8y C    23.8000  -16.1700
            22  N5x N    24.6400  -17.2900
            23  C8x C    25.9700  -16.8000
            24  N5x N    25.9700  -15.4000
            25  N4y N    24.6400  -14.9800
            26  O5x O    19.5300  -11.2700
            27  C1a C    24.2200  -13.6500
            28  N1x N    20.3000  -17.3600
            29  C8y C    28.7700  -14.9800
            30  C8x C    27.5100  -15.6800
            31  C8x C    29.9600  -15.6800
            32  S4a S    28.7700  -13.5800
            33  C8x C    27.5100  -17.0800
            34  C8x C    29.9600  -17.0800
            35  O1d O    27.3700  -13.5800
            36  O1d O    30.1700  -13.5800
            37  O1d O    28.7700  -12.2500
            38  C8y C    28.7700  -17.7800
            39  C1a C    28.7700  -19.1800
BOND        43
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12   11  12 1
            13   12   7 1
            14    1  13 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1
            21   17  20 1
            22   11  14 1 #Up
            23   12  21 1 #Down
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   21  25 1
            29   10  26 2
            30   25  27 1
            31    3  28 1
            32   28  11 1
            33   29  30 1
            34   29  31 2
            35   29  32 1
            36   30  33 2
            37   31  34 1
            38   32  35 2
            39   32  36 2
            40   32  37 1
            41   33  38 1
            42   38  39 1
            43   34  38 2

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