KEGG   DRUG: Pitolisant
Entry
D10749                      Drug                                   
Name
Pitolisant (USAN/INN);
Wakix (TN);
Ozawade (TN)
Formula
C17H26ClNO
Exact mass
295.1703
Mol weight
295.8474
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: N07XX11
Chemical structure group: DG03021
Product (DG03021): D11490<US>
Efficacy
Nootropic, H3 receptor inverse agonist/antagonist
Comment
Treatment of narcolepsy
Target
HRH3 [HSA:11255] [KO:K04151]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP2D6 [HSA:1565]; CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07X OTHER NERVOUS SYSTEM DRUGS
    N07XX Other nervous system drugs
     N07XX11 Pitolisant
      D10749  Pitolisant (USAN/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG03021  Pitolisant
    D10749  Pitolisant
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG03021  Pitolisant
     D10749  Pitolisant
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH3
     D10749  Pitolisant (USAN/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10749
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10749
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG03021  Pitolisant
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG03021  Pitolisant
Other DBs
CAS: 362665-56-3
PubChem: 273220345
LinkDB
KCF data

ATOM        20
            1   C1x C    23.6600  -16.4500
            2   C1x C    23.6600  -17.8500
            3   C1x C    22.4700  -18.5500
            4   C1x C    21.2100  -17.8500
            5   N1y N    21.2100  -16.4500
            6   C1x C    22.4700  -15.7500
            7   C1b C    20.0200  -15.7500
            8   C1b C    18.8300  -16.4500
            9   C1b C    17.6400  -15.7500
            10  O2a O    16.4500  -16.4500
            11  C1b C    15.2600  -15.7500
            12  C1b C    14.0700  -16.4500
            13  C1b C    12.8800  -15.7500
            14  C8y C    11.6900  -16.4500
            15  C8x C    11.6900  -17.8500
            16  C8x C    10.4300  -18.5500
            17  C8y C     9.2400  -17.8500
            18  C8x C     9.2400  -16.4500
            19  C8x C    10.4300  -15.7500
            20  X   Cl    8.0500  -18.5500
BOND        21
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1
            21   17  20 1

» Japanese version   » Back

DBGET integrated database retrieval system